SCHEMBL9609680

SCHEMBL9609680

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nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.45
PGD P52209 2/20 0.31
CYP2C9 P11712 1/20 0.31
PDE4A P27815 1/20 0.31
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10002061 1.00 TSHR (0.45) TSHRPGDCYP2C9PDE4ATP53
SCHEMBL2616762 1.00 TSHR (0.45) TSHRPGDCYP2C9PDE4ATP53
SCHEMBL9609679 1.00 TSHR (0.45) TSHRPGDCYP2C9PDE4ATP53
SCHEMBL17693480 1.00 TSHR (0.45) TSHRPGDCYP2C9PDE4ATP53
SCHEMBL3453885 0.79 TSHR (0.45) TSHRPGDCYP2C9PDE4ATP53
SCHEMBL28150772 0.77 TSHR (0.43) TSHRPGDCYP2C9PDE4A
SCHEMBL28163286 0.77 TSHR (0.43) TSHRPGDCYP2C9PDE4A
SCHEMBL13017376 0.76
SCHEMBL13017377 0.76
SCHEMBL15859132 0.75 TSHR (0.41) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230277500-A1 COMPOSITIONS COMPRISING ATICAPRANT Janssen Pharmaceuticals, Inc. 2023-09-07 US disclosed
US-11739050-B2 Method for purification of terpenoid amino alcohol derivatives SCI PHARMTECH INC. (TW) 2023-08-29 US disclosed
US-20180093981-A1 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors GENZYME CORPORATION 2018-04-05 US disclosed
US-20170258802-A1 METHOD OF TREATING POLYCYSTIC KIDNEY DISEASES WITH CERAMIDE DERIVATIVES GENZYME CORPORATION 2017-09-14 US disclosed
US-9744153-B2 2-acylaminopropoanol-type glucosylceramide synthase inhibitors GENZYME CORPORATION (US) 2017-08-29 US disclosed
US-9745294-B2 2-acylaminopropoanol-type glucosylceramide synthase inhibitors GENZYME CORPORATION (US) 2017-08-29 US disclosed
US-20170210696-A1 Process for the Preparation of Metaraminol LABORATORI ALCHEMIA S.R.L. (IT) 2017-07-27 US disclosed
US-20170151145-A1 POWERFUL HAIR TREATMENT AGENT HAVING ANTI-WASHOUT EFFECT HENKEL AG & CO. KGAA (DE) 2017-06-01 US disclosed
US-20170151153-A1 POWERFUL HAIR TREATMENT AGENT WITH ANTI-WASHOUT EFFECT HENKEL AG & CO. KGAA (DE) 2017-06-01 US disclosed
US-20170015620-A1 PROCESS FOR THE PREPARATION OF EXAMETAZIME JUBILANT DRAXIMAGE INC. (CA) 2017-01-19 US disclosed
US-20120322787-A1 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2012-12-20 US disclosed
US-20120322786-A1 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GENZYME CORPORATION (US) 2012-12-20 US disclosed
US-8309593-B2 2-acylaminopropoanol-type glucosylceramide synthase inhibitors GENZYME CORPORATION (US) 2012-11-13 US disclosed
US-20120264787-A1 Respiratory Disease Treatment PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) 2012-10-18 US disclosed
US-8236786-B2 Respiratory disease treatment PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) 2012-08-07 US disclosed
US-20120136096-A1 PROTECTION OF A DISPERSING AGENT DURING A GRINDING OPERATION LAFARGE (FR) 2012-05-31 US disclosed
US-20110184021-A1 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors GENZYME CORPORATION 2011-07-28 US disclosed
US-20110166134-A1 Glucosylceramide Synthase Inhibition For The Treatment Of Collapsing Glomerulopathy And Other Glomerular Disease GENZYME CORPORATION 2011-07-07 US disclosed
US-20110053945-A1 SALTS OF 6-(5-CHLORO-2-PYRIDYL)-5-[(4-METHYL-1-PIPERAZINYL)CARBONYLOXY]-7-OXO-6,7-DIHY-DRO-5H-PYRROLO[3,4-B]PYRAZINE SEPRACOR INC. (US) 2011-03-03 US disclosed
US-20110053986-A1 RESPIRATORY DISEASE TREATMENT PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053945-A1 SALTS OF 6-(5-CHLORO-2-PYRIDYL)-5-[(4-METHYL-1-PIPERAZINYL)CARBONYLOXY]-7-OXO-6,7-DIHY-DRO-5H-PYRROLO[3,4-B]PYRAZINE MDH2, SLC25A11, MDH1 TSHR 3075/4885PGD 80/4885CYP2C9 1405/4885
US-20170151145-A1 POWERFUL HAIR TREATMENT AGENT HAVING ANTI-WASHOUT EFFECT OAT, HOGA1, LGALS7; LGALS7B TSHR 2728/4885PGD 60/4885CYP2C9 4455/4885
US-20110184021-A1 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors GBA1, GBA2, ASAH2 TSHR 3687/4885PGD 412/4885CYP2C9 1928/4885
US-20230277500-A1 COMPOSITIONS COMPRISING ATICAPRANT ADORA1, ADORA2B, ADORA2A TSHR 4710/4885PGD 2506/4885CYP2C9 98/4885
US-20120322786-A1 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS GBA1, GBA2, ASAH2 TSHR 3687/4885PGD 412/4885CYP2C9 1928/4885
US-11739050-B2 Method for purification of terpenoid amino alcohol derivatives ADH1A, MSMO1, MED1 TSHR 3612/4885PGD 757/4885CYP2C9 1529/4885
US-20170258802-A1 METHOD OF TREATING POLYCYSTIC KIDNEY DISEASES WITH CERAMIDE DERIVATIVES SGMS1, SGMS2, CERS2 TSHR 4238/4885PGD 1022/4885CYP2C9 4252/4885
US-20170210696-A1 Process for the Preparation of Metaraminol MSMO1, METAP1, M6PR TSHR 1821/4885PGD 684/4885CYP2C9 1061/4885
US-20120322787-A1 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS ASAH2, GBA1, GAA TSHR 2541/4885PGD 617/4885CYP2C9 3202/4885
US-20110166134-A1 Glucosylceramide Synthase Inhibition For The Treatment Of Collapsing Glomerulopathy And Other Glomerular Disease GBA1, UGCG, GBA2 TSHR 3985/4885PGD 451/4885CYP2C9 4539/4885
US-20170151153-A1 POWERFUL HAIR TREATMENT AGENT WITH ANTI-WASHOUT EFFECT SLC25A13, HOGA1, GCDH TSHR 2420/4885PGD 41/4885CYP2C9 4204/4885
US-20120264787-A1 Respiratory Disease Treatment IL5, PPARD, PPARG TSHR 832/4885PGD 176/4885CYP2C9 789/4885
US-20170015620-A1 PROCESS FOR THE PREPARATION OF EXAMETAZIME CUL5, SAMM50, ADRM1 TSHR 878/4885PGD 2648/4885CYP2C9 1180/4885
US-20180093981-A1 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors ASAH2, GBA1, GAA TSHR 2541/4885PGD 617/4885CYP2C9 3202/4885
US-20110053986-A1 RESPIRATORY DISEASE TREATMENT IL5, PPARD, PPARG TSHR 832/4885PGD 176/4885CYP2C9 789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.