SCHEMBL9726261

SCHEMBL9726261

CCCC(CC)OC(=O)c1ccc(C(=O)Oc2ccccc2S(=O)(=O)[O-])cc1.[Na+]

nearest known ligand 0.43

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 1/20 0.34
CA2 known ✓ P00918 1/20 0.34
PRKCA P17252 2/20 0.43
PRKCD Q05655 2/20 0.43
TSHR P16473 1/20 0.39
PRSS1 P07477 2/20 0.35
ACR P10323 2/20 0.35
NPSR1 Q6W5P4 1/20 0.34
MAPT P10636 3/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
POLB P06746 2/20 0.33
ALDH1A1 P00352 1/20 0.33
SLC6A3 Q01959 1/20 0.33
MEN1 O00255 1/20 0.33
SERPINE1 P05121 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9726265 0.89 PRKCA (0.43) PRKCAPRKCDTSHRMAPTKMT2A
SCHEMBL9726264 0.88 PRKCA (0.45) PRKCAPRKCDTSHRPRSS1ACR
SCHEMBL9726303 0.80 LMNA (0.54) TSHRPRSS1ACRNPSR1MAPT
SCHEMBL9726276 0.79 SMN1; SMN2 (0.48) TSHRNPSR1CA1CA2MAPT
SCHEMBL9726267 0.78 PRKCA (0.44) PRKCAPRKCDTSHRMAPTKMT2A
SCHEMBL10609875 0.78 MAPT (0.52) TSHRPRSS1ACRMAPTKMT2A
SCHEMBL9732670 0.78 TSHR (0.51) TSHRMAPTKMT2ASMN1; SMN2POLB
SCHEMBL9726282 0.78 SLC6A3 (0.51) TSHRPRSS1ACRCA1CA2
SCHEMBL29466993 0.77 MAPT (0.54) TSHRNPSR1MAPTKMT2ASMN1; SMN2
SCHEMBL179824 0.77 MAPT (0.54) TSHRNPSR1MAPTKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5078907-A UNSYMMETRICAL DICARBOXYLIC ESTERS AS BLEACH PRECURSORS LEVER BROTHERS COMPANY, DIVISION OF CONOPCO, INC. (US) 1992-01-07 US disclosed
EP-0426217-A2 Bleach precursors UNILEVER N.V. (NL) 1991-05-08 EP disclosed