Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14247826 | 0.84 | DHFR (0.46) | TDO2IDO2MAPTHTTMAPK1 | |
| SCHEMBL9952861 | 0.82 | TDO2 (0.46) | TDO2IDO2MAPTHTTMAPK1 | |
| SCHEMBL9953980 | 0.81 | ATM (0.51) | TDO2IDO2MAPTALDH1A1KDM4E | |
| SCHEMBL9954672 | 0.78 | TDO2 (0.52) | TDO2IDO2MAPTHTTSMN1; SMN2 | |
| SCHEMBL10289024 | 0.77 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2TP53ALDH1A1KDM4E | |
| SCHEMBL9955586 | 0.77 | HPD (0.44) | SMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL9955016 | 0.76 | ALDH1A1 (0.50) | MAPTNPC1RAB9ATP53ALOX15 | |
| SCHEMBL9954589 | 0.75 | ALOX12 (0.50) | MAPTMAPK1RAB9AALDH1A1MEN1 | |
| SCHEMBL14247524 | 0.74 | MAPT (0.47) | MAPTHTTMAPK1AHRDHFR | |
| SCHEMBL9955086 | 0.74 | CCKBR (0.43) | TDO2IDO2MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |