Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245197 | 0.83 | HCAR2 (0.48) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL1245195 | 0.83 | HCAR2 (0.48) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL18799897 | 0.83 | HCAR2 (0.44) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL23999236 | 0.79 | SMN1; SMN2 (0.44) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL3089611 | 0.78 | HCAR2 (0.60) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL12018827 | 0.78 | HCAR2 (0.60) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL1801877 | 0.78 | HCAR2 (0.60) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL23999237 | 0.77 | TAS1R3 (0.51) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL31736350 | 0.76 | HCAR2 (0.58) | CYP1A1CYP1A2CYP1B1HCAR2SMN1; SMN2 | |
| SCHEMBL21654340 | 0.75 | KCNH2 (0.38) | CYP1A2SMN1; SMN2LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240218011-A1 | GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF | FIREFLY BIO, INC. | 2024-07-04 | — | — | US | disclosed |
| US-11178871-B2 | Herbicidal pyrimidine compounds | BASF SE (DE) | 2021-11-23 | — | — | US | disclosed |
| US-20210253561-A1 | SELECTIVE LIGANDS FOR MODULATION OF GIRK CHANNELS | NORTHEASTERN UNIVERSITY | 2021-08-19 | — | — | US | disclosed |
| US-20190269133-A1 | Herbicidal Pyrimidine Compounds | BASF SE (DE) | 2019-09-05 | — | — | US | disclosed |
| US-10370340-B2 | HIV replication inhibiting pyrimidines | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-06 | — | — | US | disclosed |
| US-20190159453-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2019-05-30 | — | — | US | disclosed |
| WO-2018019574-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | BASF SE (DE) | 2018-02-01 | — | — | WO | disclosed |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-20170121292-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-04 | — | — | US | disclosed |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. | 2010-10-07 | — | — | US | disclosed |
| US-20100048664-A1 | THERAPEUTIC SUBSTITUTED PYRROLES | ALLERGAN, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100034810-A1 | PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION | JANSSEN-CILAG (FR) | 2010-02-11 | — | — | US | disclosed |
| US-20080015243-A1 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. | 2008-01-17 | — | — | US | disclosed |
| US-7265112-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-09-04 | — | — | US | disclosed |
| US-7250437-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7196095-B2 | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196095-B2 | (Pyrimidinyl) (phenyl) substituted fused heteroaryl p38 inhibiting and PKG kinase inhibiting compounds | MERCK & CO., INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |
| US-20070021449-A1 | Pyrimidine derivatives for the prevention of hiv infection | HEERES JAN | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121292-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | RRM2B, CCNO, RRM2 | CYP1A1 510/4885CYP1A2 830/4885CYP1B1 609/4885 |
| US-20070021449-A1 | Pyrimidine derivatives for the prevention of hiv infection | ADORA2B, CYP1B1, DPYD | CYP1A1 52/4885CYP1A2 67/4885CYP1B1 2/4885 |
| US-20240218011-A1 | GLUCOCORTICOID RECEPTOR AGONISTS AND CONJUGATES THEREOF | NR3C1, NR3C2, MC2R | CYP1A1 1827/4885CYP1A2 2106/4885CYP1B1 2720/4885 |
| US-20080015243-A1 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | HGF, HDGF, MET | CYP1A1 3105/4885CYP1A2 2754/4885CYP1B1 2099/4885 |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | HGF, HDGF, HGFAC | CYP1A1 4326/4885CYP1A2 3785/4885CYP1B1 3966/4885 |
| US-20100034810-A1 | PYRIMIDINE DERIVATIVES FOR THE PREVENTION OF HIV INFECTION | NOX3, CBR3, CBR1 | CYP1A1 95/4885CYP1A2 218/4885CYP1B1 107/4885 |
| US-20210253561-A1 | SELECTIVE LIGANDS FOR MODULATION OF GIRK CHANNELS | GRIK4, GRIK2, GRIK1 | CYP1A1 4671/4885CYP1A2 4577/4885CYP1B1 4633/4885 |
| US-20190269133-A1 | Herbicidal Pyrimidine Compounds | DPYD, TYMP, DHFR | CYP1A1 355/4885CYP1A2 283/4885CYP1B1 132/4885 |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | CYP1A1 2591/4885CYP1A2 2570/4885CYP1B1 2090/4885 |
| US-11178871-B2 | Herbicidal pyrimidine compounds | DPYD, TYMP, TYMS | CYP1A1 412/4885CYP1A2 358/4885CYP1B1 154/4885 |
| US-10370340-B2 | HIV replication inhibiting pyrimidines | RRM2B, CCNO, RRM2 | CYP1A1 510/4885CYP1A2 830/4885CYP1B1 609/4885 |
| US-20190159453-A1 | HERBICIDAL PYRIMIDINE COMPOUNDS | DPYD, TYMP, TYMS | CYP1A1 412/4885CYP1A2 358/4885CYP1B1 154/4885 |
| US-20100048664-A1 | THERAPEUTIC SUBSTITUTED PYRROLES | GOT2, FARS2, THPO | CYP1A1 2954/4885CYP1A2 2450/4885CYP1B1 3254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.