Spermidine

Spermidine

SCHEMBL343877

Cl.Cl.Cl.NCCCCNCCCN

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Spermidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 4/20 0.93
ESR1 known ✓ P03372 1/20 0.60
LMNA P02545 3/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
CA12 O43570 5/20 0.93
CA6 P23280 5/20 0.93
CA7 P43166 5/20 0.93
CA9 Q16790 5/20 0.93
CA14 Q9ULX7 5/20 0.93
CA5B Q9Y2D0 5/20 0.93
CA4 P22748 4/20 0.93
CA5A P35218 4/20 0.93
ALOX15 P16050 3/20 0.93
CA3 P07451 3/20 0.93
F13A1 P00488 2/20 0.93
CYP1A2 P05177 2/20 0.93
THPO P40225 2/20 0.93
CA1 P00915 2/20 0.93
UBE2N P61088 1/20 0.93
CYP2C9 P11712 1/20 0.93

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Spermidine SCHEMBL3623585 1.00 LMNA (1.00) LMNASMN1; SMN2CA12CA6CA7
Spermidine SCHEMBL7928492 1.00 LMNA (1.00) LMNASMN1; SMN2CA12CA6CA7
Spermidine SCHEMBL573651 1.00 LMNA (1.00) LMNASMN1; SMN2CA12CA6CA7
Spermidine SCHEMBL573341 1.00 LMNA (1.00) LMNASMN1; SMN2CA12CA6CA7
Spermidine SCHEMBL2514294 0.97 LMNA (0.94) LMNASMN1; SMN2CA12CA6CA7
Hydrochloric Acid SCHEMBL31268131 0.97 LMNA (0.94) LMNASMN1; SMN2CA12CA6CA7
Spermidine SCHEMBL29150448 0.97 LMNA (0.94) LMNASMN1; SMN2CA12CA6CA7
Hydrochloric Acid SCHEMBL9392489 0.97 LMNA (0.94) LMNASMN1; SMN2CA12CA6CA7
Hydrochloric Acid SCHEMBL8186500 0.97 LMNA (0.94) LMNASMN1; SMN2CA12CA6CA7
Spermine SCHEMBL1167355 0.97 UBE2N (1.00) LMNASMN1; SMN2CA12CA6CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 540 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119592557-A Extraction method and application of plant cell nucleus 河北农业大学 2025-03-11 CN claimed
WO-2024254223-A2 METHOD AND SYSTEMS FOR ISOLATING NUCLEAR RNA FROM A HIGH DEGRADATION TISSUE CASE WESTERN RESERVE UNIVERSITY (US) 2024-12-12 WO claimed
WO-2024121732-A1 COMPOSITION FOR THE MODIFIED RELEASE OF BIOLOGICAL POLYAMINES, IN PARTICULAR SPERMIDINE GIULIANI S.P.A. (IT) 2024-06-13 WO claimed
CN-117503807-A Preparation process of cordyceps militaris powder 江西仙客来生物科技有限公司 2024-02-06 CN claimed
CN-113548971-B Synthesis process of spermidine and intermediate thereof 上海朴颐化学科技有限公司 2023-12-15 CN claimed
CN-116285021-B Biodegradable multi-sensitive hydrogel and preparation method thereof 中国海洋大学 2023-10-13 CN claimed
CN-116285021-A Biodegradable multi-sensitive hydrogel and preparation method thereof 中国海洋大学 2023-06-23 CN claimed
US-20220170081-A1 METHOD FOR DETECTING TARGET NUCLEIC ACID AND KIT CANON KABUSHIKI KAISHA (JP) 2022-06-02 US claimed
US-20220142960-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC 2022-05-12 US claimed
CN-113647416-A Preparation method of multi-connection nutrient polymerization gel, product and application of multi-connection nutrient polymerization gel in crops 天津科技大学 2021-11-16 CN claimed
EP-2124922-A2 COMPOSITION COMPRISING RUTIN AND POLYUNSATURATED FATTY ACID HAVING AN INHIBITORY ACTIVITY ON 5 ALPHA-REDUCTASE Giuliani S.P.A. (IT) 2009-12-02 EP claimed
EP-2063002-A2 Method for depositing and patterning carbon nanotubes using chemical self-assembly process Samsung Electronics Co., Ltd. (KR) 2009-05-27 EP claimed
WO-2008114141-A2 COMPOSITION COMPRISING RUTIN AND POLYUNSATURATED FATTY ACID HAVING AN INHIBITORY ACTIVITY ON 5 ALPHA-REDUCTASE GIULIANI S.P.A. (IT) 2008-09-25 WO claimed
US-7232846-B2 Amines as anti-alcoholism agents GARBIL PHARMA INVESTIGACION CHILE LTDA. 2007-06-19 US claimed
US-6960425-B2 Method for laminating and patterning carbon nanotubes using chemical self-assembly process SAMSUNG ELECTRONICS CO., LTD. (KR) 2005-11-01 US claimed
US-20040242701-A1 Amines as ant-alcoholism agents GARBIL PHARMA INVESTIGACION CHILE LTDA. (CL) 2004-12-02 US claimed
EP-0789708-B1 MULTIFUNCTIONAL MOLECULAR COMPLEXES FOR GENE TRANSFER TO CELLS WYETH CORP (US) 2004-11-03 EP claimed
EP-1455007-A2 Method for depositing and patterning carbon nanotubes using chemical self-assembly process SAMSUNG ELECTRONICS CO., LTD. (KR) 2004-09-08 EP claimed
US-20040142285-A1 Method for laminating and patterning carbon nanotubes using chemical self-assembly process SAMSUNG ELECTRONICS CO., LTD. 2004-07-22 US claimed
EP-1437133-A1 AMINES WITH ANTIALCOHOLIC AGENTS Garbil Pharma Investigacion Chile Ltda. (CL) 2004-07-14 EP claimed