SCHEMBL1277178

SCHEMBL1277178

Cc1cc(Br)ccc1C=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 4/20 0.52
ALDH1A1 P00352 3/20 0.48
TSHR P16473 1/20 0.48
CYP2A6 P11509 3/20 0.44
NPC1 O15118 1/20 0.43
PKM P14618 1/20 0.43
RAB9A P51151 1/20 0.43
PTPN1 P18031 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.40
GRIA1 P42261 1/20 0.39
GRIA2 P42262 1/20 0.39
GRIA3 P42263 1/20 0.39
GRIA4 P48058 1/20 0.39
TYR P14679 1/20 0.38
HCAR1 Q9BXC0 1/20 0.37
PIM3 Q86V86 2/20 0.37
PRKDC P78527 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL144351 0.82 ERN1 (0.57) ERN1ALDH1A1TSHRCYP2A6PTPN1
SCHEMBL31401340 0.82 ERN1 (0.57) ERN1ALDH1A1TSHRCYP2A6PTPN1
SCHEMBL3040456 0.78 ERN1 (0.64) ERN1ALDH1A1CYP2A6PTPN1PTGDR2
SCHEMBL15978830 0.78 MAOB (0.41) ALDH1A1PTGDR2TYR
SCHEMBL31672723 0.77 CASP3 (0.35) ERN1ALDH1A1HCAR1CYP1A2CYP2D6
SCHEMBL27346950 0.77 MPO (0.38) ERN1ALDH1A1HCAR1CYP1A2CYP2D6
SCHEMBL17449355 0.77 ALDH1A1 (0.35) ERN1ALDH1A1TSHRHCAR1SMN1; SMN2
SCHEMBL3859028 0.77 CASP3 (0.35) ERN1ALDH1A1HCAR1CYP1A2CYP2D6
SCHEMBL28805080 0.77 HCAR1 (0.35) ERN1ALDH1A1TSHRHCAR1
SCHEMBL1162125 0.76 ERN1 (0.56) ERN1ALDH1A1CYP2A6PTPN1PTGDR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 560 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117327243-B Olefin-linked two-dimensional covalent organic framework, and preparation method and application thereof 天津师范大学 2024-04-30 CN claimed
CN-117327243-A Olefin-linked two-dimensional covalent organic framework, and preparation method and application thereof 天津师范大学 2024-01-02 CN claimed
CN-116947754-A Antitumor compound, antitumor drug, preparation method and application 北京中医药大学 2023-10-27 CN claimed
CN-113387982-B Methyl-modified cage-type phosphorus ligand, preparation method and application thereof 东莞理工学院 2022-04-19 CN claimed
CN-113387982-A Methyl-modified cage-type phosphorus ligand, preparation method and application thereof 东莞理工学院 2021-09-14 CN claimed
US-12617777-B2 GPR84 antagonists and uses thereof Liminal Biosciences Limited (GB) 2026-05-05 US disclosed
US-12583839-B2 PD-L1 antagonist compound ADLAI NORTYE BIOPHARMA CO., LTD. (CN) 2026-03-24 US disclosed
CN-116916924-B MALT1 modulators and uses thereof 稀有生物科学股份有限公司 2026-02-27 CN disclosed
EP-4103557-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-02-18 EP disclosed
EP-4673150-A2 COMPOSITIONS AND METHODS FOR TREATING MALT1 ASSOCIATED DISEASES Rarefied Biosciences, Inc. (US) 2026-01-07 EP disclosed
US-12503473-B2 Triazolopyrimidine compounds and their use in treating cancer DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) 2025-12-23 US disclosed
US-12502378-B2 Monoacylglycerol lipase modulators for use in autism spectrum disorders JANSSEN PHARMACEUTICA NV (BE) 2025-12-23 US disclosed
EP-1351924-A2 DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Pharma Company (US) 2003-10-15 EP disclosed
US-20030060459-A1 Diamines as modulators of chemokine receptor activity BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-03-27 US disclosed
WO-2003022842-A1 THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-03-20 WO disclosed
EP-1233013-A1 NOVEL PHENYLALANINE DERIVATIVES Ajinomoto Co., Inc. (JP) 2002-08-21 EP disclosed
WO-2002050019-A2 DIAMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB PHARMA CO. (US) 2002-06-27 WO disclosed
EP-1131322-A2 DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE ABBOTT LABORATORIES (US) 2001-09-12 EP disclosed
WO-2000024741-A2 DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS ABBOTT LABORATORIES (US) 2000-05-04 WO disclosed
EP-0104432-A2 Herbicide and plant growth regulator comprising alpha-beta-unsaturated compound TEIJIN LIMITED (JP) 1984-04-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12503473-B2 Triazolopyrimidine compounds and their use in treating cancer ABCC4, ABCB1, SLC16A3 ERN1 3600/4885ALDH1A1 205/4885TSHR 1609/4885
US-12617777-B2 GPR84 antagonists and uses thereof GPR84, GPR88, GPR3 ERN1 2787/4885ALDH1A1 2463/4885TSHR 303/4885
US-12502378-B2 Monoacylglycerol lipase modulators for use in autism spectrum disorders LIPC, LPL, MGLL ERN1 3729/4885ALDH1A1 266/4885TSHR 3000/4885
US-20030060459-A1 Diamines as modulators of chemokine receptor activity CCL11, CCR1, CCR2 ERN1 1646/4885ALDH1A1 296/4885TSHR 1900/4885
US-12583839-B2 PD-L1 antagonist compound CD274, PDCD1LG2, PDCD1 ERN1 2884/4885ALDH1A1 747/4885TSHR 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.