Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.59 |
| ▸ | HTR7 | P34969 | 6/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | HTR3A | P46098 | 7/20 | 0.52 |
| ▸ | HTR6 | P50406 | 4/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.52 |
| ▸ | HTR3B | O95264 | 3/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059249 | 0.87 | HTR3A (0.65) | HTR1AHTR7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1298770 | 0.86 | DRD2 (0.51) | HTR1AHTR7HTR6DRD2DRD3 | |
| SCHEMBL547174 | 0.83 | HTR1A (0.77) | HTR1AHTR7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6963568 | 0.79 | HTR6 (0.65) | HTR1AHTR7HTR3AHTR6HTR3E | |
| SCHEMBL7055686 | 0.78 | HTR1A (0.50) | HTR1AHTR7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL233151 | 0.75 | HTR3A (0.71) | HTR1AHTR7HTR3AHTR6HTR3E | |
| SCHEMBL30747759 | 0.75 | HTR3A (0.71) | HTR1AHTR7HTR3AHTR6HTR3E | |
| SCHEMBL14060577 | 0.74 | HTR7 (1.00) | HTR1AHTR7HTR3AHTR6HTR3E | |
| SCHEMBL23708324 | 0.74 | ALDH1A1 (0.57) | HTR1AHTR3AHTR6HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL4905371 | 0.74 | HTR3A (0.69) | HTR1AHTR7HTR3AHTR6HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846655-B2 | 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-09-30 | — | — | US | disclosed |
| US-8846655-B2 | 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-09-30 | — | — | US | disclosed |
| US-8846655-B2 | 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-09-30 | — | — | US | disclosed |
| US-20120302541-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-11-29 | — | — | US | disclosed |
| US-20120302541-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-11-29 | — | — | US | disclosed |
| US-20120302541-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-11-29 | — | — | US | disclosed |
| EP-2493852-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110269759-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269759-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-11-03 | — | — | US | disclosed |
| US-20110269759-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2011-11-03 | — | — | US | disclosed |
| WO-2011053706-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
| WO-2011053706-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302541-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | OPRK1, OPRD1, OPRM1 | HTR1A 15/4885HTR7 120/4885SLC6A2 542/4885 |
| US-20110269759-A1 | PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS | OPRD1, OPRK1, OPRM1 | HTR1A 81/4885HTR7 557/4885SLC6A2 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.