SCHEMBL14060577

SCHEMBL14060577

COc1ccc(-c2ccccc2N2CCNCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR7 P34969 11/20 1.00
▸ HTR1A P08908 7/20 1.00
▸ HTR6 P50406 3/20 0.69
▸ HTR2A P28223 1/20 0.69
▸ HTR5A P47898 1/20 0.69
▸ HTR3A P46098 7/20 0.59
▸ HTR3E A5X5Y0 3/20 0.58
▸ HTR3B O95264 3/20 0.58
▸ HTR3D Q70Z44 3/20 0.58
▸ HTR3C Q8WXA8 3/20 0.58
▸ ADRB1 P08588 2/20 0.58
▸ SIGMAR1 Q99720 2/20 0.58
▸ DRD2 P14416 1/20 0.58
▸ CYP2C19 P33261 1/20 0.58
▸ DRD3 P35462 1/20 0.58
▸ HTR2B P41595 2/20 0.57
▸ HTR1B P28222 1/20 0.57
▸ LMNA P02545 1/20 0.56
▸ MAPT P10636 1/20 0.56
▸ HTR1D P28221 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7921826 0.98 HTR7 (0.97) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL30022433 0.82 HTR7 (1.00) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL3759275 0.82 HTR7 (1.00) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL29106727 0.81 HTR7 (0.67) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL30663734 0.81 HTR7 (0.67) HTR7HTR1AHTR6HTR2AHTR5A
Hydrochloric Acid SCHEMBL1673713 0.80 HTR7 (0.96) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL941809 0.80 HTR7 (1.00) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL547174 0.79 HTR1A (0.77) HTR7HTR1AHTR6HTR3AHTR3E
SCHEMBL113953 0.78 HTR7 (0.64) HTR7HTR1AHTR6HTR2AHTR5A
SCHEMBL9058691 0.78 HTR7 (1.00) HTR7HTR1AHTR6HTR2AHTR5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118708925-B Novel method for extracting regional atmosphere waveguide based on AIS signal 江苏海洋大学 2025-05-27 — — CN claimed
WO-2026101714-A1 UNIVERSAL T CELL TARGETED INFLUENZA VACCINE CONSTRUCT SAINT LOUIS UNIVERSITY (US) 2026-05-15 — — WO disclosed
US-12595442-B2 Lipase variants and compositions comprising surfactant and lipase variant NOVOZYMES A/S (DK) 2026-04-07 — — US disclosed
US-20260048138-A1 NOVEL PI3K AND/OR PIKK INHIBITORS, ANTIBODY-DRUG CONJUGATES COMPRISING THE SAME AND USES THEREOF HUTCHMED LTD (CN) 2026-02-19 — — US disclosed
US-20260049343-A1 Compound Library and Method for Producing Compound Library UNIV TOKYO (JP) 2026-02-19 — — US disclosed
US-12514802-B2 Polymer/hydrophobic ester oil blend DOW SILICONES CORPORATION (US) 2026-01-06 — — US disclosed
EP-3518888-B1 ALKYL-PHTALIDES FOR USE IN THE COSMETIC TREATMENT OF NAILS SEDERMA SA (FR) 2025-11-19 — — EP disclosed
US-20250339353-A1 A HIGH SPF GEL COMPOSITION CONOPCO, INC., D/B/A UNILEVER (US) 2025-11-06 — — US disclosed
US-20250302720-A1 PEPTIDE-BASED HAIR TREATMENT SEDERMA (FR) 2025-10-02 — — US disclosed
US-12427095-B2 Sprayable compositions BEIERSDORF AG (DE) 2025-09-30 — — US disclosed
CN-114047438-A State identification method, system and device for circuit breaker operating mechanism and electronic equipment 中国南方电网有限责任公司超高压输电公司广州局 2022-02-15 — — CN disclosed
US-20220040069-A1 TITANIUM DIOXIDE DISPERSION CRODA INTERNATIONAL PLC (GB) 2022-02-10 — — US disclosed
EP-3950000-A1 EMULSION COMPOSITION COMPRISING ULTRAVIOLET WAVELENGTH CONVERSION SUBSTANCE AND ORGANIC OILY PHASE THICKENER Shiseido Company, Ltd. (JP) 2022-02-09 — — EP disclosed
US-20220031602-A1 SKIN PERFECTING COSMETIC COMPOSITIONS AND METHODS OF USE L'OREAL (FR) 2022-02-03 — — US disclosed
CN-113984300-A Nonrust steel pipe body gas tightness quick testing arrangement 深圳中鼎工业科技有限公司 2022-01-28 — — CN disclosed
US-9260400-B2 I-arylpiperazinic ligands of 5-HT7 receptor and use thereof UNIVERSITA' DEGLI STUDI DI BARI “ALDO MORO” (IT) 2016-02-16 — — US disclosed
EP-2816037-A2 New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof Università degli Studi di Bari "Aldo Moro" (IT) 2014-12-24 — — EP disclosed
WO-2014079504-A1 POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF BIOFORDRUG S.R.L. (IT) 2014-05-30 — — WO disclosed
US-20140086834-A1 NEW I-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF UNIVERSITA' DEGLI STUDI DI BARI ''ALDO MORO'' (IT) 2014-03-27 — — US disclosed
WO-2012159662-A1 NEW 1-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF UNIVERSITA' DEGLI STUDI DI BARI (IT) 2012-11-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260048138-A1 NOVEL PI3K AND/OR PIKK INHIBITORS, ANTIBODY-DRUG CONJUGATES COMPRISING THE SAME AND USES THEREOF PIK3R5, PIK3R4, PIK3CD HTR7 3582/4885HTR1A 3334/4885HTR6 2123/4885
US-20220031602-A1 SKIN PERFECTING COSMETIC COMPOSITIONS AND METHODS OF USE CUTA, DSG1, SMURF1 HTR7 1129/4885HTR1A 1799/4885HTR6 3296/4885
US-20260049343-A1 Compound Library and Method for Producing Compound Library MLX, HM13, LPXN HTR7 3704/4885HTR1A 3189/4885HTR6 3074/4885
US-12595442-B2 Lipase variants and compositions comprising surfactant and lipase variant LPL, PNLIP, LIPE HTR7 2543/4885HTR1A 4170/4885HTR6 3270/4885
US-20250302720-A1 PEPTIDE-BASED HAIR TREATMENT MC1R, PNISR, NPY1R HTR7 968/4885HTR1A 181/4885HTR6 1238/4885
US-20140086834-A1 NEW I-ARYLPIPERAZINIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF HTR7, HTR2C, HTR5A HTR7 1/4885HTR1A 5/4885HTR6 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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