SCHEMBL1305546

SCHEMBL1305546

CC(N)Cc1c[nH]c2ccc(Cl)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 7/20 1.00
HTR2C P28335 4/20 0.68
HTR1A P08908 3/20 0.68
HTR2B P41595 3/20 0.68
HTR1B P28222 3/20 0.68
HTR1D P28221 2/20 0.68
CYP1A2 P05177 1/20 0.68
CYP2D6 P10635 1/20 0.68
CYP2C9 P11712 1/20 0.68
NFKB1 P19838 1/20 0.68
CYP2C19 P33261 1/20 0.68
GPR84 Q9NQS5 1/20 0.63
ADRB1 P08588 1/20 0.62
ADRA2A P08913 1/20 0.62
SLC6A2 P23975 1/20 0.62
HTR1E P28566 1/20 0.62
SLC6A4 P31645 1/20 0.62
HTR7 P34969 1/20 0.62
HTR6 P50406 1/20 0.62
SLC6A3 Q01959 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21292945 1.00 HTR2A (1.00) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL29527375 1.00 HTR2A (1.00) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL14511411 0.87 HTR2A (0.77) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL23649381 0.85 HTR2A (0.74) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL25002265 0.84 HTR2A (0.73) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL1304961 0.84 HTR2A (0.73) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL19068711 0.83 HTR2A (0.72) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL24913231 0.83 HTR2A (0.70) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL1120488 0.83 HTR2A (0.70) HTR2AHTR2CHTR1AHTR2BHTR1B
SCHEMBL30811419 0.83 HTR2A (0.70) HTR2AHTR2CHTR1AHTR2BHTR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108493-A1 COMPOSITIONS COMPRISING A SEROTONERGIC TRYPTAMINE COMPOUND CAAMTECH, INC. (US) 2026-04-23 US disclosed
US-20260092034-A1 7-AZAINDOLE ANALOGS AND METHODS OF TREATING NEUROLOGICAL DISORDERS USING THE SAME KULEON LLC (US) 2026-04-02 US disclosed
US-12570602-B2 Selective serotonin receptor modulators and methods of making and using the same Park City Bio, LLC (US) 2026-03-10 US disclosed
US-12564560-B1 Selective serotonin receptor modulators and methods of making and using the same Park City Bio, LLC (US) 2026-03-03 US disclosed
US-20250376436-A1 Selective Serotonin Receptor Modulators and Methods of Making and Using the Same Park City Bio, LLC (US) 2025-12-11 US disclosed
US-20250340513-A1 NEUROPLASTOGENS AND NON-HALLUCINOGENIC SEROTONIN 5-HT2A/2C RECEPTOR MODULATORS KULEON LLC (US) 2025-11-06 US disclosed
US-12441683-B2 7-methyl indole analogs and dosage forms containing the same Kuleon, LLC (US) 2025-10-14 US disclosed
US-20250289817-A1 SEROTONIN RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME KULEON LLC (US) 2025-09-18 US disclosed
US-12414936-B2 Compositions comprising a serotonergic tryptamine compound CAAMTECH, INC. (US) 2025-09-16 US disclosed
US-20250282722-A1 7-METHYL INDOLE ANALOGS AND DOSAGE FORMS CONTAINING THE SAME KULEON LLC (US) 2025-09-11 US disclosed
US-8399453-B2 Organic compounds NOVARTIS AG (CH) 2013-03-19 US disclosed
US-20110275613-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2011-11-10 US disclosed
US-20110275613-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2011-11-10 US disclosed
US-20110275613-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2011-11-10 US disclosed
US-8053442-B2 Organic compounds NOVARTIS AG (CH) 2011-11-08 US disclosed
US-8053442-B2 Organic compounds NOVARTIS AG (CH) 2011-11-08 US disclosed
CN-102015711-A Spiro-indole derivatives for the treatment of parasitic diseases NOVARTIS AG 2011-04-13 CN disclosed
WO-2009132921-A1 SPIRO-INDOLE DERIVATIVES FOR THE TREATMENT OF PARASITIC DISEASES NOVARTIS AG (CH) 2009-11-05 WO disclosed
US-20090275560-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2009-11-05 US disclosed
US-20090275560-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2009-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250376436-A1 Selective Serotonin Receptor Modulators and Methods of Making and Using the Same HTR1A, HTR4, HTR5A HTR2A 8/4885HTR2C 7/4885HTR1A 1/4885
US-20260092034-A1 7-AZAINDOLE ANALOGS AND METHODS OF TREATING NEUROLOGICAL DISORDERS USING THE SAME HTR2C, HTR7, HTR6 HTR2A 6/4885HTR2C 1/4885HTR1A 5/4885
US-20250282722-A1 7-METHYL INDOLE ANALOGS AND DOSAGE FORMS CONTAINING THE SAME HTR7, HTR2C, HTR1A HTR2A 8/4885HTR2C 2/4885HTR1A 3/4885
US-20250289817-A1 SEROTONIN RECEPTOR MODULATORS AND METHODS OF MAKING AND USING THE SAME HTR5A, HTR1A, HTR3A HTR2A 5/4885HTR2C 11/4885HTR1A 2/4885
US-12441683-B2 7-methyl indole analogs and dosage forms containing the same HTR7, HTR2C, HTR1A HTR2A 8/4885HTR2C 2/4885HTR1A 3/4885
US-12414936-B2 Compositions comprising a serotonergic tryptamine compound HTR3A, HTR2A, HTR5A HTR2A 2/4885HTR2C 11/4885HTR1A 5/4885
US-20090275560-A1 ORGANIC COMPOUNDS OTC, PC, OAT HTR2A 4638/4885HTR2C 4428/4885HTR1A 4699/4885
US-20260108493-A1 COMPOSITIONS COMPRISING A SEROTONERGIC TRYPTAMINE COMPOUND ADRA2C, ADRB3, ADRA2B HTR2A 19/4885HTR2C 12/4885HTR1A 22/4885
US-20250340513-A1 NEUROPLASTOGENS AND NON-HALLUCINOGENIC SEROTONIN 5-HT2A/2C RECEPTOR MODULATORS HTR2A, HTR2C, HTR3A HTR2A 1/4885HTR2C 2/4885HTR1A 4/4885
US-12570602-B2 Selective serotonin receptor modulators and methods of making and using the same HTR1D, HTR1A, HTR4 HTR2A 14/4885HTR2C 6/4885HTR1A 2/4885
US-20110275613-A1 ORGANIC COMPOUNDS OTC, PC, OAT HTR2A 4625/4885HTR2C 4430/4885HTR1A 4697/4885
US-12564560-B1 Selective serotonin receptor modulators and methods of making and using the same HTR5A, HTR1A, HTR1D HTR2A 16/4885HTR2C 7/4885HTR1A 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.