Sugi Predict

Sugi Predict / Compounds / SCHEMBL13657243

SCHEMBL13657243

SCHEMBL13657243

CC(C)(C)n1cnc2c(=O)[nH]cnc21

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PI4KA P42356 1/20 0.51
▸ PI4K2B Q8TCG2 1/20 0.51
▸ PI4K2A Q9BTU6 1/20 0.51
▸ PI4KB Q9UBF8 1/20 0.51
▸ HPRT1 P00492 10/20 0.48
▸ PNP P00491 2/20 0.47
▸ LMNA P02545 2/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.40
▸ ALB P02768 1/20 0.40
▸ MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22883459 0.87 HPRT1 (0.46) PI4KAPI4K2BPI4K2API4KBHPRT1
SCHEMBL19033992 0.84 HPRT1 (0.47) PI4KAPI4K2BPI4K2API4KBHPRT1
SCHEMBL21417467 0.84 PNP (0.46) HPRT1PNPLMNAMEN1KMT2A
SCHEMBL23774611 0.84 HPRT1 (0.47) PI4KAPI4K2BPI4K2API4KBHPRT1
SCHEMBL24767723 0.82 PNP (0.47) HPRT1PNPLMNAMEN1KMT2A
SCHEMBL23934886 0.79 PNP (0.46) HPRT1PNPLMNAMEN1KMT2A
SCHEMBL1992701 0.78 HPRT1 (0.54) HPRT1PNPALDH1A1
SCHEMBL21372049 0.77 PNP (0.44) HPRT1PNPLMNAMEN1KMT2A
SCHEMBL13012219 0.76 TYMP (0.45) HPRT1LMNAMEN1KMT2AALDH1A1
SCHEMBL5021598 0.76 XDH (0.55) PI4KAPI4K2BPI4K2API4KBPNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12037636-B2 Polynucleotide synthesis method, kit and system OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2024-07-16 — — US disclosed
US-20240026358-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2024-01-25 — — US disclosed
US-20240026358-A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF WAVE LIFE SCIENCES LTD. (SG) 2024-01-25 — — US disclosed
US-20230382932-A1 Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2023-11-30 — — US disclosed
US-20230383296-A1 MODIFIED GAPMER OLIGOMERS AND METHODS OF USE THEREOF ALIGOS THERAPEUTICS, INC. (US) 2023-11-30 — — US disclosed
US-20230382932-A1 Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes) PFIZER INC. (US) 2023-11-30 — — US disclosed
US-20230374058-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. 2023-11-23 — — US disclosed
US-20230372372-A1 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS TRUSTEES OF TUFTS COLLEGE 2023-11-23 — — US disclosed
US-20230374058-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE ROME THERAPEUTICS, INC. 2023-11-23 — — US disclosed
US-20230331763-A1 COMPOSITIONS AND METHODS FOR CAPPING RNAS VERVE THERAPEUTICS, INC. 2023-10-19 — — US disclosed
US-20140242046-A1 INHIBITION AND ENHANCEMENT OF REPROGRAMMING BY CHROMATIN MODIFYING ENZYMES Childern's Medical Center Corporation (US) 2014-08-28 — — US disclosed
US-20140051654-A1 Substituted Purine and 7-Deazapurine Compounds Epizyme, Inc. (US) 2014-02-20 — — US disclosed
US-20130018018-A1 NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS Epiphany Biosciences ,Inc. (US) 2013-01-17 — — US disclosed
US-20130018018-A1 NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS Epiphany Biosciences ,Inc. (US) 2013-01-17 — — US disclosed
US-20130018011-A1 METHOD OF TREATING DENGUE FEVER RIBOSCIENCE LLC 2013-01-17 — — US disclosed
US-20130018011-A1 METHOD OF TREATING DENGUE FEVER RIBOSCIENCE LLC 2013-01-17 — — US disclosed
US-7608599-B2 Antiviral phosphoramidates ROCHE PALO ALTO LLC (US) 2009-10-27 — — US disclosed
US-7608599-B2 Antiviral phosphoramidates ROCHE PALO ALTO LLC (US) 2009-10-27 — — US disclosed
US-20070042988-A1 Antiviral phosphoramidates ROCHE PALO ALTO LLC 2007-02-22 — — US disclosed
US-20070042988-A1 Antiviral phosphoramidates ROCHE PALO ALTO LLC 2007-02-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042988-A1 Antiviral phosphoramidates RPP30, RNASE1, ADORA2B PI4KA 1389/4885PI4K2B 919/4885PI4K2A 864/4885
US-20230374058-A1 COMPOUNDS AND METHODS FOR TREATING DISEASE EHMT1, POLRMT, RNASE1 PI4KA 829/4885PI4K2B 1230/4885PI4K2A 1029/4885
US-20130018018-A1 NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS PNP, TYMP, ENTPD5 PI4KA 287/4885PI4K2B 383/4885PI4K2A 315/4885
US-20230372372-A1 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS CASP1, CASP2, APAF1 PI4KA 1399/4885PI4K2B 1775/4885PI4K2A 1405/4885
US-20230382932-A1 Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes) STING1, IRF3, CGAS PI4KA 2704/4885PI4K2B 2660/4885PI4K2A 2740/4885
US-20230331763-A1 COMPOSITIONS AND METHODS FOR CAPPING RNAS RNGTT, NSUN2, RNMT PI4KA 3250/4885PI4K2B 2567/4885PI4K2A 2429/4885
US-20230383296-A1 MODIFIED GAPMER OLIGOMERS AND METHODS OF USE THEREOF GJA1, GAP43, GJB2 PI4KA 2139/4885PI4K2B 2271/4885PI4K2A 2166/4885
US-20140051654-A1 Substituted Purine and 7-Deazapurine Compounds TPMT, DIMT1, DAZAP1 PI4KA 3070/4885PI4K2B 3345/4885PI4K2A 3188/4885
US-20130018011-A1 METHOD OF TREATING DENGUE FEVER C5, C1QBP, C1R PI4KA 4762/4885PI4K2B 4282/4885PI4K2A 4021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.