SCHEMBL14928752

SCHEMBL14928752

CNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 7/20 1.00
ADORA1 P30542 7/20 1.00
PGK1 P00558 1/20 0.77
PGK2 P07205 1/20 0.77
CYP2C19 P33261 2/20 0.71
ADORA2B P29275 3/20 0.67
SLC29A1 Q99808 3/20 0.67
ADORA2A P29274 2/20 0.65
HTR2A P28223 1/20 0.64
CYP1A2 P05177 1/20 0.64
CYP2D6 P10635 1/20 0.64
CYP2C9 P11712 1/20 0.64
MAPK1 P28482 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6758941 1.00 ADORA3 (1.00) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL4803033 1.00 ADORA3 (1.00) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL27578766 1.00 ADORA3 (1.00) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL14853634 1.00 ADORA3 (1.00) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL5879766 1.00 ADORA3 (1.00) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL18464461 1.00 ADORA3 (1.00) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL21276447 0.92 ADORA3 (0.86) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL22224967 0.91 ADORA3 (0.84) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL23760829 0.90 ADORA3 (0.82) ADORA3ADORA1PGK1PGK2CYP2C19
SCHEMBL20724628 0.90 ADORA3 (0.82) ADORA3ADORA1PGK1PGK2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3505176-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS Moderna Therapeutics, Inc. (US) 2019-07-03 EP disclosed
EP-3501550-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE Moderna Therapeutics, Inc. (US) 2019-06-26 EP disclosed
US-9878056-B2 Modified polynucleotides for the production of cosmetic proteins and peptides MODERNATX, INC. (US) 2018-01-30 US disclosed
US-9827332-B2 Modified polynucleotides for the production of proteins MODERNATX, INC. (US) 2017-11-28 US disclosed
US-9828416-B2 Modified polynucleotides for the production of secreted proteins MODERNATX, INC. (US) 2017-11-28 US disclosed
US-9790531-B2 Enzymes and polymerases for the synthesis of RNA MODERNATX, INC. (US) 2017-10-17 US disclosed
US-9782462-B2 Modified polynucleotides for the production of proteins associated with human disease MODERNATX, INC. (US) 2017-10-10 US disclosed
US-20170130255-A1 ENZYMES AND POLYMERASES FOR THE SYNTHESIS OF RNA MODERNATX, INC. (US) 2017-05-11 US disclosed
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF MODERNATX, INC. 2017-03-02 US disclosed
US-9572897-B2 Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins MODERNATX, INC. (US) 2017-02-21 US disclosed
US-20140179771-A1 MODIFIED POLYNUCLEOTIDES FOR TREATING DOLICHYL-PHOSPHATE (UDP-N-ACETYLGLUCOSAMINE) N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE 1 (GLCNAC-1-P TRANSFERASE) PROTEIN DEFICIENCY MODERNA THERAPEUTICS, INC. (US) 2014-06-26 US disclosed
US-20140171485-A1 MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE MODERNA THERAPEUTICS, INC. (US) 2014-06-19 US disclosed
US-20140155473-A1 MODIFIED GLUCOSIDASE, BETA, ACID POLYNUCLEOTIDES FOR TREATING PROTEIN DEFICIENCY Moderna Threrapeutics, Inc. (US) 2014-06-05 US disclosed
US-20140141067-A1 MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 MODERNA THERAPEUTICS, INC. (US) 2014-05-22 US disclosed
US-20140010861-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE modeRNA Therapeutics (US) 2014-01-09 US disclosed
US-20130237594-A1 SPLIT DOSE ADMINISTRATION modeRNA Therapeutics (US) 2013-09-12 US disclosed
US-20130165504-A1 METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT modeRNA Therapeutics (US) 2013-06-27 US disclosed
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS modeRNA Therapeutics (US) 2013-06-20 US disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 US disclosed
US-20130115272-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140141067-A1 MODIFIED POLYNUCLEOTIDES ENCODING SEPTIN-4 SEPTIN7, SEPTIN9, SEPTIN8 ADORA3 4093/4885ADORA1 4452/4885PGK1 3226/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 ADORA3 103/4885ADORA1 161/4885PGK1 1089/4885
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 ADORA3 103/4885ADORA1 161/4885PGK1 1089/4885
US-20130165504-A1 METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT RNGTT, L3MBTL3, RNASE1 ADORA3 1746/4885ADORA1 2140/4885PGK1 1821/4885
US-20130237594-A1 SPLIT DOSE ADMINISTRATION IGF2BP1, IGF2BP2, NSUN2 ADORA3 3341/4885ADORA1 3230/4885PGK1 3450/4885
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 ADORA3 413/4885ADORA1 366/4885PGK1 2738/4885
US-20140179771-A1 MODIFIED POLYNUCLEOTIDES FOR TREATING DOLICHYL-PHOSPHATE (UDP-N-ACETYLGLUCOSAMINE) N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE 1 (GLCNAC-1-P TRANSFERASE) PROTEIN DEFICIENCY POLRMT, POLN, GALNT1 ADORA3 2408/4885ADORA1 2256/4885PGK1 405/4885
US-20140010861-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE POLRMT, POLM, POLN ADORA3 3596/4885ADORA1 3902/4885PGK1 2201/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.