Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14654978 | 0.92 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10KMT2APOLBHTT | |
| SCHEMBL15199111 | 0.92 | SMN1; SMN2 (0.56) | SMN1; SMN2HSD17B10KMT2APOLBHTT | |
| SCHEMBL15199524 | 0.91 | SMN1; SMN2 (0.71) | SMN1; SMN2HSD17B10KMT2AEPHX1NAAA | |
| SCHEMBL12984256 | 0.91 | SMN1; SMN2 (0.78) | SMN1; SMN2HSD17B10KMT2AEPHX1NAAA | |
| SCHEMBL18177036 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2HSD17B10KMT2APOLBHTT | |
| SCHEMBL13701828 | 0.90 | SMN1; SMN2 (0.75) | SMN1; SMN2HSD17B10KMT2AEPHX1NAAA | |
| SCHEMBL6233457 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2HSD17B10KMT2APOLBGNAI3 | |
| SCHEMBL26704145 | 0.85 | HSD17B10 (0.53) | SMN1; SMN2HSD17B10POLBCACNA1GGNAI3 | |
| SCHEMBL22472644 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10KMT2APOLBHTT | |
| SCHEMBL19703677 | 0.84 | HSD17B10 (0.49) | SMN1; SMN2HSD17B10KMT2APOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348450-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION | 2023-11-02 | — | — | US | disclosed |
| EP-3600287-B1 | INHIBITORS OF KINASE NETWORKS AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2023-07-05 | — | — | EP | disclosed |
| US-20210371420-A1 | INHIBITORS OF KINASE NETWORKS AND USES THEREOF | PURDUE RESEARCH FOUNDATION | 2021-12-02 | — | — | US | disclosed |
| US-20210309652-A1 | ISOXAZOLINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | FMC CORPORATION | 2021-10-07 | — | — | US | disclosed |
| US-11040973-B2 | Inhibitors of kinase networks and uses thereof | PURDUE RESEARCH FOUNDATION | 2021-06-22 | — | — | US | disclosed |
| US-20200308173-A1 | INHIBITORS OF KINASE NETWORKS AND USES THEREOF | PURDUE RESEARCH FOUNDATION | 2020-10-01 | — | — | US | disclosed |
| US-20190077803-A1 | TETRACYCLINE COMPOUNDS | TETRAPHASE PHARMACEUTICALS INC (US) | 2019-03-14 | — | — | US | disclosed |
| US-20190071407-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2019-03-07 | — | — | US | disclosed |
| US-10030029-B2 | Imidazole derivative used as antiviral agent and use thereof in preparation of medicament | SHANDONG DANHONG PHARMACEUTICAL CO., LTD. (CN) | 2018-07-24 | — | — | US | disclosed |
| US-10017507-B2 | Diaza-benzofluoranthrene compounds | HARBIN PHARMACEUTICAL GROUP CO., LTD. GENERAL PHARMACEUTICAL FACTORY (CN) | 2018-07-10 | — | — | US | disclosed |
| US-8703759-B2 | Fused heterocyclic compounds as ion channel modulators | GILEAD SCIENCES, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20130217666-A1 | TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR | GENENTECH, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| WO-2013067267-A1 | ROD -LIKE HEPATITIS C VIRUS INHIBITORS CONTAINING THE FRAGEMENT {2- [4- (BI PHENYL - 4 - YL) - 1H - IMIDAZO - 2 - YL] PYRROLIDINE - 1 - CARBONLYMETHYL} AMINE | THERAVANCE, INC. (US) | 2013-05-10 | — | — | WO | disclosed |
| US-20120316124-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120010192-A1 | Fused Heterocyclic Compounds as Ion Channel Modulators | GILEAD SCIENCES, INC. | 2012-01-12 | — | — | US | disclosed |
| US-7906556-B2 | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20110021521-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-7858629-B2 | Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-12-28 | — | — | US | disclosed |
| US-20090239862-A1 | 3-{(3S)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3 -[(isopropylamino)carbonyl]-1-piperazinyl}-1-naphthoic acid, useful for the treatment, control, or prevention of obesity and diabetes | MERCK SHARP & DOHME CORP. | 2009-09-24 | — | — | US | disclosed |
| US-20070149569-A1 | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239862-A1 | 3-{(3S)-4-{[1-(3-ethoxyphenyl)-2-(4-methylphenyl)-1H-imidazol-4-yl]carbonyl}-3 -[(isopropylamino)carbonyl]-1-piperazinyl}-1-naphthoic acid, useful for the treatment, control, or prevention of obesity and diabetes | CCKAR, CCKBR, GIPR | SMN1; SMN2 3632/4885HSD17B10 2089/4885KMT2A 3747/4885 |
| US-20200308173-A1 | INHIBITORS OF KINASE NETWORKS AND USES THEREOF | KDM1B, JMJD6, KDM1A | SMN1; SMN2 2311/4885HSD17B10 2862/4885KMT2A 39/4885 |
| US-20120010192-A1 | Fused Heterocyclic Compounds as Ion Channel Modulators | KCNJ2, KCNH2, CACNA1E | SMN1; SMN2 1093/4885HSD17B10 2247/4885KMT2A 3048/4885 |
| US-20210309652-A1 | ISOXAZOLINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS | PRDX1, CYP4X1, RDX | SMN1; SMN2 2688/4885HSD17B10 3219/4885KMT2A 1882/4885 |
| US-20230348450-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | BPGM, PGAM1, PGM2 | SMN1; SMN2 915/4885HSD17B10 669/4885KMT2A 2181/4885 |
| US-20190071407-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | SMN1; SMN2 1519/4885HSD17B10 3011/4885KMT2A 2695/4885 |
| US-11040973-B2 | Inhibitors of kinase networks and uses thereof | KDM1B, JMJD6, KDM1A | SMN1; SMN2 2311/4885HSD17B10 2862/4885KMT2A 39/4885 |
| US-20210371420-A1 | INHIBITORS OF KINASE NETWORKS AND USES THEREOF | KDM1B, JMJD6, KDM1A | SMN1; SMN2 2311/4885HSD17B10 2862/4885KMT2A 39/4885 |
| US-20120316124-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | CHRM1, ACHE, P2RX7 | SMN1; SMN2 1367/4885HSD17B10 3019/4885KMT2A 2629/4885 |
| US-20130217666-A1 | TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR | NFKB1, NFKBIA, RELA | SMN1; SMN2 3723/4885HSD17B10 1245/4885KMT2A 3437/4885 |
| US-20110021521-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNJ2, KCNH2, KCNA3 | SMN1; SMN2 1673/4885HSD17B10 2866/4885KMT2A 3427/4885 |
| US-20190077803-A1 | TETRACYCLINE COMPOUNDS | TUBB, TUBA1C, TUBA1A | SMN1; SMN2 3203/4885HSD17B10 660/4885KMT2A 2833/4885 |
| US-10017507-B2 | Diaza-benzofluoranthrene compounds | DDT, CYP3A43, CYP19A1 | SMN1; SMN2 2387/4885HSD17B10 736/4885KMT2A 598/4885 |
| US-20070149569-A1 | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors | APP, DNPEP, PREP | SMN1; SMN2 1276/4885HSD17B10 1326/4885KMT2A 3358/4885 |
| US-10030029-B2 | Imidazole derivative used as antiviral agent and use thereof in preparation of medicament | MAVS, ZC3HAV1, SARS1 | SMN1; SMN2 2646/4885HSD17B10 4588/4885KMT2A 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.