Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.63 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48723 | 1.00 | MMP2 (0.63) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| SCHEMBL27925721 | 1.00 | MMP2 (0.63) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| SCHEMBL29367294 | 1.00 | MMP2 (0.63) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| SCHEMBL26108766 | 0.98 | MMP2 (0.61) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| SCHEMBL28508112 | 0.98 | MMP2 (0.61) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2285638 | 0.98 | MMP2 (0.61) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| Hydrazine SCHEMBL28369279 | 0.98 | MMP2 (0.61) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| SCHEMBL8070950 | 0.98 | MMP2 (0.61) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| SCHEMBL8070939 | 0.98 | MMP2 (0.61) | MMP2G6PDCASP7CASP6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28051606 | 0.96 | MMP2 (0.59) | MMP2G6PDCASP7CASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919855-B2 | Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide | UNICHEM LABORATORIES LTD (IN) | 2021-02-16 | — | — | US | claimed |
| US-20200181085-A1 | NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE | UNICHEM LABORATORIES LTD (IN) | 2020-06-11 | — | — | US | claimed |
| US-11639332-B2 | Methods and compositions of isoindoline-1,3-dione and isoindole prodrugs useful for treating cancer, ulcerative colitis and related inflammatory diseases | Amgen (Europe) GmbH (CH) | 2023-05-02 | — | — | US | disclosed |
| US-11549926-B2 | Detection of nitrogen containing and nitrogen free explosives | SCINTREX TRACE CORPORATION (CA) | 2023-01-10 | — | — | US | disclosed |
| US-20220267305-A1 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2022-08-25 | — | — | US | disclosed |
| US-11384063-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2022-07-12 | — | — | US | disclosed |
| EP-3341359-B1 | PROCESS FOR PREPARATION OF APREMILAST | GLENMARK LIFE SCIENCES LTD (IN) | 2022-03-23 | — | — | EP | disclosed |
| EP-3878837-A1 | 2,5- OR 2,6-DISUBSTITUTED HYDROQUINONE DERIVATIVES WITH AT LEAST ONE CARBOXY, SULFO OR AMIDO GROUP USEFUL AS MEDICAMENTS | OM Pharma SA (CH) | 2021-09-15 | — | — | EP | disclosed |
| US-11040024-B2 | Methods of using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione | AMGEN INC. (US) | 2021-06-22 | — | — | US | disclosed |
| US-11008288-B1 | Methods for preparation of apremilast | NATIONAL TAIWAN NORMAL UNIVERSITY (TW) | 2021-05-18 | — | — | US | disclosed |
| US-10919855-B2 | Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide | UNICHEM LABORATORIES LTD (IN) | 2021-02-16 | — | — | US | disclosed |
| US-20080085527-A1 | Using luminescent based recipes for measurement of creatine, uric acid and glucose in bodily fluids | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-04-10 | — | — | US | disclosed |
| US-20080085527-A1 | Using luminescent based recipes for measurement of creatine, uric acid and glucose in bodily fluids | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2008-04-10 | — | — | US | disclosed |
| US-20080027123-A1 | Reduction of levels of tumor necrosis factor-alpha and/or inhibition of phosphodiesterase 4; treating erythema nodosum leprosum in leprosy, rhematoid spondylitis, hepatitis or congestive heart failure | CELGENE CORPORATION | 2008-01-31 | — | — | US | disclosed |
| US-20070287362-A1 | POLISHING COMPOSITION AND METHOD OF POLISHING WITH THE SAME | FUJIFILM CORPORATION | 2007-12-13 | — | — | US | disclosed |
| US-7244546-B2 | Planographic printing method and planographic printing plate precursor used therein | FUJIFILM CORPORATION (JP) | 2007-07-17 | — | — | US | disclosed |
| US-7244546-B2 | Planographic printing method and planographic printing plate precursor used therein | FUJIFILM CORPORATION (JP) | 2007-07-17 | — | — | US | disclosed |
| US-20070128680-A1 | Hydrazines and derivatives production process from hydrazines and dicarboxylic acid | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO-UFRG (BR) | 2007-06-07 | — | — | US | disclosed |
| US-20070128680-A1 | Hydrazines and derivatives production process from hydrazines and dicarboxylic acid | UNIVERSIDADE FEDERAL DO RIO DE JANEIRO-UFRG (BR) | 2007-06-07 | — | — | US | disclosed |
| US-20070004920-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | CELGENE CORPORATION AN ORGNIZATION OF THE STATE NEW JERSEY (US) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11040024-B2 | Methods of using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione | PDE4A, PDE2A, PDE4B | MMP2 65/4885G6PD 478/4885CASP7 341/4885 |
| US-20200181085-A1 | NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE | BCKDK, DMPK, MYLK | MMP2 3292/4885G6PD 2775/4885CASP7 3724/4885 |
| US-11384063-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ADRM1, MDM2, ESR2 | MMP2 2227/4885G6PD 4176/4885CASP7 3465/4885 |
| US-20070128680-A1 | Hydrazines and derivatives production process from hydrazines and dicarboxylic acid | LDHA, CA5A, LDHB | MMP2 751/4885G6PD 1379/4885CASP7 2145/4885 |
| US-10919855-B2 | Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide | DMPK, BCKDK, MYLK | MMP2 3292/4885G6PD 3186/4885CASP7 4003/4885 |
| US-11008288-B1 | Methods for preparation of apremilast | APRT, ALDH3A1, TPMT | MMP2 4282/4885G6PD 263/4885CASP7 2071/4885 |
| US-20220267305-A1 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ADRM1, MDM2, ESR2 | MMP2 2227/4885G6PD 4176/4885CASP7 3465/4885 |
| US-11639332-B2 | Methods and compositions of isoindoline-1,3-dione and isoindole prodrugs useful for treating cancer, ulcerative colitis and related inflammatory diseases | PDE4A, PDE3B, PDE4B | MMP2 222/4885G6PD 156/4885CASP7 138/4885 |
| US-20070004920-A1 | Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds | TNF, DHPS, IL1A | MMP2 2700/4885G6PD 205/4885CASP7 1591/4885 |
| US-20080027123-A1 | Reduction of levels of tumor necrosis factor-alpha and/or inhibition of phosphodiesterase 4; treating erythema nodosum leprosum in leprosy, rhematoid spondylitis, hepatitis or congestive heart failure | TNF, PDE4A, LITAF | MMP2 235/4885G6PD 157/4885CASP7 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.