SCHEMBL1691202

SCHEMBL1691202

CC(C)(C)Cc1ccc(C(=O)c2ccccc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
THRA P10827 1/20 0.56
THRB P10828 1/20 0.56
ALDH1A1 P00352 5/20 0.54
SRD5A2 P31213 1/20 0.52
ELANE P08246 3/20 0.50
PPARG P37231 3/20 0.50
ESR1 P03372 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.49
ATM Q13315 2/20 0.49
HTT P42858 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
HPGD P15428 3/20 0.49
RAB9A P51151 3/20 0.48
NPC1 O15118 1/20 0.48
TDP1 Q9NUW8 1/20 0.47
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
PPARA Q07869 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9497128 0.84 AKR1C3 (0.60) THRATHRBALDH1A1ESR1ATM
SCHEMBL19067708 0.84 L3MBTL1 (0.57) ALDH1A1SRD5A2L3MBTL1ATMSMN1; SMN2
SCHEMBL25237891 0.84 THRA (0.51) THRATHRBALDH1A1ESR1L3MBTL1
SCHEMBL4679096 0.82 THRB (0.61) THRATHRBALDH1A1SRD5A2ESR1
SCHEMBL14609622 0.81 ALDH1A1 (0.46) ALDH1A1SRD5A2ELANEPPARGL3MBTL1
SCHEMBL11883898 0.81 ALDH1A1 (0.54) ALDH1A1SRD5A2ELANEPPARGL3MBTL1
Benzophenone SCHEMBL27920919 0.81 ALDH1A1 (0.54) ALDH1A1SRD5A2ELANEL3MBTL1ATM
SCHEMBL10944429 0.79 ALDH1A1 (0.47) ALDH1A1SRD5A2ELANEPPARGL3MBTL1
SCHEMBL21514121 0.79 THRA (0.50) THRATHRBALDH1A1SRD5A2ELANE
SCHEMBL20906861 0.78 THRA (0.61) THRATHRBALDH1A1PPARGESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702571-B2 Adhesive sheet for temporary fixation and method of manufacturing semiconductor device using the same LG CHEM, LTD. (KR) 2023-07-18 US disclosed
US-20220204497-A1 NOVEL COMPOUND HAVING ANTICANCER ACTIVITY, AND METHOD FOR PRODUCING SAME DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2022-06-30 US disclosed
US-20210171802-A1 ADHESIVE SHEET FOR TEMPORARY FIXATION AND METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE USING THE SAME LG CHEM, LTD. (KR) 2021-06-10 US disclosed
US-20210171688-A1 BIOCOMPATIBLE COPOLYMER, CURABLE COMPOSITION, BIOCOMPATIBLE COATING LAYER AND BIOCOMPATIBLE DEVICE INCLUDING THE SAME NATIONAL CENTRAL UNIVERSITY (TW) 2021-06-10 US disclosed
US-20210147585-A1 Polyacrylate macromolecular photoinitiator, synthesis method therefor and use thereof INSIGHT HIGH TECHNOLOGY CO., LTD (CN) 2021-05-20 US disclosed
US-10022371-B2 Procaspase-activating compounds and methods THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-07-17 US disclosed
US-9695189-B2 Chemical crosslinkers and compositions thereof Nguyen, Mark Quang (US) 2017-07-04 US disclosed
US-20170166560-A1 FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-06-15 US disclosed
US-20170166560-A1 FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-06-15 US disclosed
US-9669038-B1 Heterocyclic compounds and uses thereof GLOBAVIR BIOSCIENCES, INC. (US) 2017-06-06 US disclosed
US-8716492-B2 Five-membered heterocycles useful as serine protease inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-05-06 US disclosed
US-20130123262-A1 NOVEL TRIAZINEDIONE DERIVATIVES AS GABAB RECEPTOR MODULATORS ADDEX PHARMA S.A. (CH) 2013-05-16 US disclosed
US-20130096133-A1 PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS The Board of Trustees of the University lllinois (US) 2013-04-18 US disclosed
US-20130045935-A1 FLAVONOID DIMERS AND THEIR USE THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2013-02-21 US disclosed
US-20130045935-A1 FLAVONOID DIMERS AND THEIR USE THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2013-02-21 US disclosed
US-8344138-B2 Triazinedione derivatives as GABAB receptor modulators ADDEX PHARMA S.A. (CH) 2013-01-01 US disclosed
US-20120088758-A1 FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-04-12 US disclosed
US-20100004246-A1 NOVEL TRIAZINEDIONE DERIVATIVES AS GABAB RECEPTOR MODULATORS ADDEX PHARMA SA (CH) 2010-01-07 US disclosed
US-20080009512-A1 Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes ASTRAZENECA AB (SE) 2008-01-10 US disclosed
US-20080009512-A1 Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes ASTRAZENECA AB (SE) 2008-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170166560-A1 FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS F12, F11, F5 THRA 2459/4885THRB 3410/4885ALDH1A1 4184/4885
US-20100004246-A1 NOVEL TRIAZINEDIONE DERIVATIVES AS GABAB RECEPTOR MODULATORS CHRNA5, GABRA5, GABRB3 THRA 1762/4885THRB 504/4885ALDH1A1 3515/4885
US-20120088758-A1 FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS F12, F11, F5 THRA 2459/4885THRB 3410/4885ALDH1A1 4184/4885
US-20130045935-A1 FLAVONOID DIMERS AND THEIR USE DHFR, CCNY, ETFB THRA 4783/4885THRB 4504/4885ALDH1A1 4252/4885
US-20080009512-A1 Tetrahydroquinolones and Aza-Analogues Thereof for Use as Dpp-IV Inhibitors in the Treatment of Diabetes DPP4, DPP8, DPP3 THRA 748/4885THRB 735/4885ALDH1A1 418/4885
US-20220204497-A1 NOVEL COMPOUND HAVING ANTICANCER ACTIVITY, AND METHOD FOR PRODUCING SAME TPX2, AIMP2, CDYL2 THRA 4856/4885THRB 4848/4885ALDH1A1 2153/4885
US-20130096133-A1 PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS CASP3, CASP5, CASP6 THRA 4766/4885THRB 4750/4885ALDH1A1 3462/4885
US-10022371-B2 Procaspase-activating compounds and methods CASP3, CASP5, CASP6 THRA 4768/4885THRB 4734/4885ALDH1A1 3075/4885
US-20130123262-A1 NOVEL TRIAZINEDIONE DERIVATIVES AS GABAB RECEPTOR MODULATORS CHRNA5, GABRA5, GABRB3 THRA 1762/4885THRB 504/4885ALDH1A1 3515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.