SCHEMBL1700780

SCHEMBL1700780

COC(=O)C(F)(F)C(F)(F)OC

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.36
ALDH1A1 P00352 3/20 0.35
KCNN4 O15554 1/20 0.32
MAPT P10636 2/20 0.32
MEN1 O00255 1/20 0.32
LMNA P02545 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP1A2 P05177 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
KDM4E B2RXH2 1/20 0.30
CRHBP P24387 1/20 0.30
MAPK1 P28482 1/20 0.30
CRHR2 Q13324 1/20 0.30
HSD17B10 Q99714 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL517250 0.83 ALDH1A1 (0.45) DGAT1ALDH1A1KCNN4MAPTMEN1
SCHEMBL4377505 0.80 DGAT1 (0.33) DGAT1ALDH1A1KCNN4CYP1A2CYP2C9
SCHEMBL19106976 0.80
SCHEMBL30387559 0.78 ALDH1A1 (0.33) DGAT1ALDH1A1
SCHEMBL497763 0.78 DGAT1 (0.39) DGAT1ALDH1A1KCNN4MAPTMEN1
SCHEMBL517272 0.78 DGAT1 (0.39) DGAT1ALDH1A1KCNN4MAPTMEN1
SCHEMBL9569891 0.78
SCHEMBL1129794 0.78 ALDH1A1 (0.42) DGAT1ALDH1A1KCNN4MAPTMEN1
SCHEMBL16329830 0.77 ALDH1A1 (0.32) DGAT1ALDH1A1
SCHEMBL3082673 0.76 THRB (0.40) DGAT1ALDH1A1KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119285464-A Preparation method of methoxy tetrafluoro methyl propionate 福建海德福新材料有限公司 2025-01-10 CN claimed
CN-117558895-A Simple method for improving surface stability of high-nickel positive electrode material 浙江海创锂电科技有限公司 2024-02-13 CN claimed
US-5206422-A Process for preparation of fluorinated carbonyl compounds THE DOW CHEMICAL COMPANY (US) 1993-04-27 US claimed
US-4608206-A USED TO GIVE COPOLYMERS WITH ETHYLENICALLY UNSATURATED COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1986-08-26 US claimed
US-20250388590-A1 PROCESSES FOR THE PREPARATION OF SUBSTITUTED 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-b]INDOLES HOFFMANN-LA ROCHE INC. (US) 2025-12-25 US disclosed
US-12448386-B2 Processes for the preparation of substituted 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indoles HOFFMANN-LA ROCHE INC. (US) 2025-10-21 US disclosed
WO-2025111296-A1 ELECTROLYTE COMPOSITIONS AND ELECTROCHEMICAL DEVICES USING THE SAME II-VI DELAWARE, INC. (US) 2025-05-30 WO disclosed
CN-119285464-A Preparation method of methoxy tetrafluoro methyl propionate 福建海德福新材料有限公司 2025-01-10 CN disclosed
US-20240174678-A1 PROCESSES FOR SYNTHESIS OF SUBSTITUTED INDOLE INTERMEDIATES FOR THE SYNTHESIS OF SERD COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2024-05-30 US disclosed
CN-117558895-A Simple method for improving surface stability of high-nickel positive electrode material 浙江海创锂电科技有限公司 2024-02-13 CN disclosed
US-11873305-B2 Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds GENENTECH, INC. (US) 2024-01-16 US disclosed
US-11873305-B2 Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds GENENTECH, INC. (US) 2024-01-16 US disclosed
US-4474899-A Process for preparing ester fluorinated ion exchange polymer precursor by acid treatment of ether E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-10-02 US disclosed
US-4357282-A CONTACTING A FLUORINATED METHYL OR ETHYL EHTER HAVING A METHOXYLATED CARBON ATOM WITH A LEWIS ACID CATALYST ACYLATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-11-02 US disclosed
US-4349650-A Polyfluoroallyloxy compounds, their preparation and copolymers therefrom E. I. DU PONT DE NEMOURS AND COMPANY (US) 1982-09-14 US disclosed
US-4304927-A Carboxylic acids, esters and salts of polyfluoroacetone E. I. DUPONT DE NEMOURS AND COMPANY (US) 1981-12-08 US disclosed
US-4292449-A Polyfluoroallyloxy compounds, their preparation and copolymers therefrom E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-09-29 US disclosed
US-4275225-A Polyfluoroallyloxy compounds, their preparation and copolymers therefrom E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-23 US disclosed
US-4273729-A CARBONYL OR SULFONYL FLUORIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-16 US disclosed
US-4273728-A NITRILES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-06-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388590-A1 PROCESSES FOR THE PREPARATION OF SUBSTITUTED 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-b]INDOLES SLC6A9, SLC6A1, SLC9A1 DGAT1 4254/4885ALDH1A1 775/4885KCNN4 1118/4885
US-11873305-B2 Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds WEE1, WEE2, INMT DGAT1 3251/4885ALDH1A1 2335/4885KCNN4 3697/4885
US-12448386-B2 Processes for the preparation of substituted 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indoles WEE1, WEE2, PGK1 DGAT1 3527/4885ALDH1A1 3168/4885KCNN4 624/4885
US-20240174678-A1 PROCESSES FOR SYNTHESIS OF SUBSTITUTED INDOLE INTERMEDIATES FOR THE SYNTHESIS OF SERD COMPOUNDS INMT, SPR, PGD DGAT1 3581/4885ALDH1A1 1765/4885KCNN4 4335/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.