SCHEMBL18559596

SCHEMBL18559596

CCCCCCC(CCCCC)c1cccnc1

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.50
TDP1 Q9NUW8 1/20 0.50
TBXAS1 P24557 10/20 0.47
LMNA P02545 3/20 0.43
POLB P06746 1/20 0.43
CFTR P13569 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
GOPC Q9HD26 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
KCNA5 P22460 1/20 0.42
KCNH2 Q12809 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20940017 1.00 L3MBTL1 (0.50) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL18842833 1.00 L3MBTL1 (0.50) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL25003559 1.00 L3MBTL1 (0.50) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL14028947 0.98 L3MBTL1 (0.49) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL18848784 0.98 L3MBTL1 (0.49) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL18473557 0.98 L3MBTL1 (0.51) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL18910475 0.97 L3MBTL1 (0.47) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL25067012 0.97 L3MBTL1 (0.47) L3MBTL1TDP1TBXAS1LMNAPOLB
SCHEMBL26751590 0.97 L3MBTL1 (0.50) L3MBTL1TDP1TBXAS1LMNACFTR
Hydrochloric Acid SCHEMBL29251873 0.95 L3MBTL1 (0.46) L3MBTL1TDP1TBXAS1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11752149-B2 Muscarinic acetylcholine M1 receptor antagonists Pipeline Therapeutics, Inc. (US) 2023-09-12 US disclosed
US-20230250106-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-08-10 US disclosed
US-20230159543-A1 ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-05-25 US disclosed
US-20230045142-A1 SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES THE JOHNS HOPKINS UNIVERSITY (US) 2023-02-09 US disclosed
US-20230031406-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS AG (CH) 2023-02-02 US disclosed
US-20230011652-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NOVARTIS AG (CH) 2023-01-12 US disclosed
US-11352343-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2022-06-07 US disclosed
US-20220169613-A1 Drp1-FILAMIN COMPLEX FORMATION INHIBITORS Rdiscovery, LLC 2022-06-02 US disclosed
US-20220162186-A1 PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, AND USES RELATED THERETO EMORY UNIVERSITY 2022-05-26 US disclosed
US-20210161889-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CONTINEUM THERAPEUTICS, INC. 2021-06-03 US disclosed
US-10351570-B2 Compounds and uses thereof KALA PHARMACEUTICALS, INC. (US) 2019-07-16 US disclosed
US-10316022-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2019-06-11 US disclosed
US-10294243-B2 Bicyclic compounds as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-05-21 US disclosed
US-10023536-B2 Suprametallogels and uses thereof MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2018-07-17 US disclosed
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF KALA BIO, Inc. 2018-02-08 US disclosed
US-9790180-B2 Piperidine derivatives as HDAC1/2 inhibitors REGENACY PHARMACEUTICALS, LLC (US) 2017-10-17 US disclosed
US-9669046-B2 Biodefenses using triazole-containing macrolides CEMPRA PHARMACEUTICALS, INC. (US) 2017-06-06 US disclosed
US-20170101422-A1 Bicyclic compounds as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-04-13 US disclosed
US-20170073311-A1 SUPRAMETALLOGELS AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2017-03-16 US disclosed
US-9580421-B2 Urea derivatives and uses thereof KALA PHARMACEUTICALS, INC. (US) 2017-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220169613-A1 Drp1-FILAMIN COMPLEX FORMATION INHIBITORS FIS1, DNM1L, DNM1 L3MBTL1 4525/4885TDP1 757/4885TBXAS1 3714/4885
US-20230031406-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NLRP1, NLRP3, NOD1 L3MBTL1 4789/4885TDP1 1532/4885TBXAS1 636/4885
US-20230250106-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 L3MBTL1 2331/4885TDP1 75/4885TBXAS1 202/4885
US-10316022-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 L3MBTL1 4827/4885TDP1 3546/4885TBXAS1 2117/4885
US-11352343-B2 Urea derivatives and uses thereof UACA, RB1, FLT1 L3MBTL1 4827/4885TDP1 3546/4885TBXAS1 2117/4885
US-20230011652-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NLRP1, NLRP3, NOD1 L3MBTL1 4782/4885TDP1 1513/4885TBXAS1 647/4885
US-20180037572-A1 UREA DERIVATIVES AND USES THEREOF UACA, RB1, FLT1 L3MBTL1 4827/4885TDP1 3546/4885TBXAS1 2117/4885
US-11752149-B2 Muscarinic acetylcholine M1 receptor antagonists CHRM1, CHRM2, CHRM5 L3MBTL1 1260/4885TDP1 1551/4885TBXAS1 2463/4885
US-20220162186-A1 PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, AND USES RELATED THERETO PTGER2, PTGES2, PTGES L3MBTL1 4867/4885TDP1 3360/4885TBXAS1 191/4885
US-20230159543-A1 ANTHELMINTIC PYRROLOPYRIDAZINE COMPOUNDS IL5, EPX, MPO L3MBTL1 4043/4885TDP1 3020/4885TBXAS1 2183/4885
US-10023536-B2 Suprametallogels and uses thereof PDCD1LG2, PDCD2L, PYGL L3MBTL1 513/4885TDP1 2137/4885TBXAS1 1825/4885
US-20210161889-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CHRM1, CHRM2, CHRM5 L3MBTL1 1260/4885TDP1 1551/4885TBXAS1 2463/4885
US-10294243-B2 Bicyclic compounds as pesticides DDT, BCHE, CYCS L3MBTL1 340/4885TDP1 2969/4885TBXAS1 3214/4885
US-20170101422-A1 Bicyclic compounds as pesticides DDT, BCHE, CYCS L3MBTL1 340/4885TDP1 2969/4885TBXAS1 3214/4885
US-20170073311-A1 SUPRAMETALLOGELS AND USES THEREOF PDCD1LG2, PDCD2L, PYGL L3MBTL1 513/4885TDP1 2137/4885TBXAS1 1825/4885
US-10351570-B2 Compounds and uses thereof RB1, VEGFA, FLT4 L3MBTL1 4854/4885TDP1 3830/4885TBXAS1 1794/4885
US-20230045142-A1 SMALL MOLECULE RPN13 INHIBITORS WITH ANTITUMOR PROPERTIES MRPS23, RPP30, RPS19 L3MBTL1 1159/4885TDP1 2524/4885TBXAS1 3116/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.