Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 known ✓ | P47870 | 2/20 | 0.40 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.37 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.37 |
| ▸ | ESR2 known ✓ | Q92731 | 2/20 | 0.37 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1908071 | 0.84 | ALDH1A1 (0.52) | POLBGABRA1GABRB2TDP1CA1 | |
| SCHEMBL7806960 | 0.84 | GABRA1 (0.43) | POLBGABRA1GABRB2KDM4ECA1 | |
| SCHEMBL15824990 | 0.81 | GABRA1 (0.41) | POLBGABRA1GABRB2KDM4ECA1 | |
| SCHEMBL3089041 | 0.81 | HSD17B1 (0.50) | POLBGABRA1GABRB2KDM4ECA1 | |
| SCHEMBL3283491 | 0.80 | HSP90AB1 (0.42) | POLBGABRA1GABRB2ESR1ESR2 | |
| SCHEMBL10693946 | 0.80 | CYP3A4 (0.54) | GABRA1GABRB2KDM4ECA1CA2 | |
| SCHEMBL729988 | 0.79 | HSD17B1 (0.50) | POLBKDM4ETDP1CA1CA2 | |
| SCHEMBL29230369 | 0.78 | CA12 (0.56) | KDM4ECA1CA2PTPN1ALDH1A1 | |
| SCHEMBL1355711 | 0.77 | KDM4E (0.47) | POLBGABRA1GABRB2KDM4ECA2 | |
| SCHEMBL3873140 | 0.77 | CA1 (0.47) | POLBGABRA1GABRB2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230125630-A1 | POLYPHOSPHAZENES, METHODS OF MAKING, AND USES THEREOF | UNIV MARYLAND (US) | 2023-04-27 | — | — | US | disclosed |
| US-11472927-B2 | Polyphosphazenes, methods of making, and uses thereof | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2022-10-18 | — | — | US | disclosed |
| US-20180327550-A1 | POLYPHOSPHAZENES, METHODS OF MAKING, AND USES THEREOF | UNIVERSITY OF MARYLAND, COLLEGE PARK | 2018-11-15 | — | — | US | disclosed |
| EP-3377560-A1 | POLYPHOSPHAZENES, METHODS OF MAKING, AND USES THEREOF | University of Maryland, College Park (US) | 2018-09-26 | — | — | EP | disclosed |
| US-20160377620-A1 | COMBINATION HEPATITIS C VIRUS ANTIGEN AND ANTIBODY DETECTION METHOD | ABBOTT LABORATORIES | 2016-12-29 | — | — | US | disclosed |
| US-9470686-B2 | Combination hepatitis C virus antigen and antibody detection method | ABBOTT LABORATORIES (US) | 2016-10-18 | — | — | US | disclosed |
| EP-2064551-B1 | COMBINATION HEPATITIS C VIRUS ANTIGEN AND ANTIBODY DETECTION METHOD | ABBOTT LAB (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2910949-A1 | Combination hepatitis C virus antigen and antibody detection method | Abbott Laboratories (US) | 2015-08-26 | — | — | EP | disclosed |
| US-20150177242-A1 | COMBINATION HEPATITIS C VIRUS ANTIGEN AND ANTIBODY DETECTION METHOD | ABBOTT LABORATORIES | 2015-06-25 | — | — | US | disclosed |
| US-8865398-B2 | Combination hepatitis C virus antigen and antibody detection method | ABBOTT LABORATORIES (US) | 2014-10-21 | — | — | US | disclosed |
| US-5760271-A | Production of polyorganophosphazenes | VIRUS RESEARCH INSTITUTE, INC. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5736401-A | Stabilized standards and calibrators containing rapamycin and tactrolimus bound to FK binding proteins | ABBOTT LABORATORIES (US) | 1998-04-07 | — | — | US | disclosed |
| EP-0832433-A1 | STABILIZED STANDARDS AND CALIBRATORS | Abbott Laboratories (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0634016-A4 | ASSAY VERIFICATION CONTROL FOR ANALYTICAL METHODS. | ABBOTT LAB (US) | 1997-06-04 | — | — | EP | disclosed |
| US-5635406-A | Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies | ABBOTT LABORATORIES (US) | 1997-06-03 | — | — | US | disclosed |
| WO-1996041184-A1 | STABILIZED STANDARDS AND CALIBRATORS | ABBOTT LABORATORIES (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0634016-A1 | ASSAY VERIFICATION CONTROL FOR ANALYTICAL METHODS | ABBOTT LABORATORIES (US) | 1995-01-18 | — | — | EP | disclosed |
| WO-1994024568-A1 | STABLE AQUEOUS FK506 STANDARDS | ABBOTT LABORATORIES (US) | 1994-10-27 | — | — | WO | disclosed |
| US-5338684-A | Stable aqueous FK506 standards | ABBOTT LABORATORIES (US) | 1994-08-16 | — | — | US | disclosed |
| WO-1993020443-A1 | ASSAY VERIFICATION CONTROL FOR ANALYTICAL METHODS | ABBOTT LABORATORIES (US) | 1993-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230125630-A1 | POLYPHOSPHAZENES, METHODS OF MAKING, AND USES THEREOF | PHOSPHO1, PLCG2, PLCG1 | GABRA1 1134/4885GABRB2 1954/4885CA1 299/4885 |
| US-20180327550-A1 | POLYPHOSPHAZENES, METHODS OF MAKING, AND USES THEREOF | PHOSPHO1, PLCG2, PLCG1 | GABRA1 1134/4885GABRB2 1954/4885CA1 299/4885 |
| US-11472927-B2 | Polyphosphazenes, methods of making, and uses thereof | PHOSPHO1, PLCG2, PLCG1 | GABRA1 1134/4885GABRB2 1954/4885CA1 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.