Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | EBP | Q15125 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5536172 | 0.95 | MAOA (0.50) | MAOB | |
| SCHEMBL5542660 | 0.93 | MAOA (0.52) | MAOB | |
| SCHEMBL5542033 | 0.93 | MAOA (0.52) | MAOB | |
| SCHEMBL187890 | 0.91 | EBP (0.57) | KDM4EHRH3EBPSIGMAR1 | |
| SCHEMBL2574799 | 0.87 | ATP4A (0.49) | HRH3 | |
| SCHEMBL2181780 | 0.84 | DRD2 (0.46) | KDM4EEBPSIGMAR1 | |
| SCHEMBL25288225 | 0.82 | EBP (0.43) | KDM4EEBPSIGMAR1 | |
| SCHEMBL2181408 | 0.82 | DRD2 (0.44) | EBPSIGMAR1 | |
| SCHEMBL6676718 | 0.81 | LTA4H (0.62) | KDM4E | |
| SCHEMBL188273 | 0.81 | KDM4E (0.63) | KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 249 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-07-07 | — | — | US | claimed |
| US-7737285-B2 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | TRANSTECH PHARMA, INC. (US) | 2010-06-15 | — | — | US | claimed |
| WO-2010014798-A2 | PYRIMIDOTRIAZINEDIONES AND PYRIMIDOPYRIMIDINEDIONES AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-02-04 | — | — | WO | claimed |
| US-20070213347-A1 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | TRANSTECH PHARMA (US) | 2007-09-13 | — | — | US | claimed |
| EP-1482931-A2 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | Transtech Pharma, Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| US-20040082542-A1 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | VTV THERAPEUTICS LLC | 2004-04-29 | — | — | US | claimed |
| WO-2003075921-A2 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA, INC. (US) | 2003-09-18 | — | — | WO | claimed |
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) | 2023-06-15 | — | — | US | disclosed |
| US-11261185-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2022-03-01 | — | — | US | disclosed |
| US-11026936-B2 | Piperidinyl-propanone derivatives | MERCK PATENT GMBH (DE) | 2021-06-08 | — | — | US | disclosed |
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | MERCK PATENT GMBH (DE) | 2021-01-07 | — | — | US | disclosed |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | MERCK PATENT GMBH (DE) | 2020-11-10 | — | — | US | disclosed |
| US-20200253949-A1 | PIPERIDINYL-PROPANONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-08-13 | — | — | US | disclosed |
| WO-2003075921-A2 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA, INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| EP-1155001-A4 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | LION BIOSCIENCE AG (DE) | 2003-05-28 | — | — | EP | disclosed |
| EP-1155001-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050406-A1 | ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES | LION BIOSCIENCE AG (DE) | 2000-08-31 | — | — | WO | disclosed |
| EP-0072932-B1 | PIPERAZINONES, THEIR PREPARATION AND USE | CASSELLA Aktiengesellschaft (DE) | 1990-01-17 | — | — | EP | disclosed |
| US-4598079-A | MEMORY DISORDERS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1986-07-01 | — | — | US | disclosed |
| EP-0072932-A2 | Piperazinones, their preparation and use | CASSELLA Aktiengesellschaft (DE) | 1983-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11026936-B2 | Piperidinyl-propanone derivatives | PDK2, PDK3, PDK1 | KDM4E 1276/4885HRH3 3449/4885EBP 702/4885 |
| US-20210002278-A1 | BICYCLIC HETEROCYCLIC DERIVATIVES | PDK1, PDK2, PDK3 | KDM4E 1395/4885HRH3 3582/4885EBP 1300/4885 |
| US-20040082542-A1 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | AGER, S100A4, S100B | KDM4E 3968/4885HRH3 978/4885EBP 2679/4885 |
| US-20200253949-A1 | PIPERIDINYL-PROPANONE DERIVATIVES | PDK2, PDK3, PDK1 | KDM4E 1276/4885HRH3 3449/4885EBP 702/4885 |
| US-10829489-B2 | Bicyclic heterocyclic derivatives | PDK1, PDK2, PDK3 | KDM4E 1395/4885HRH3 3582/4885EBP 1300/4885 |
| US-20230181524-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | TCF4, TCF7L2, CTNNB1 | KDM4E 2362/4885HRH3 4039/4885EBP 958/4885 |
| US-11261185-B2 | Bicyclic heterocyclic derivatives | PDK1, PDK2, PDK3 | KDM4E 1395/4885HRH3 3582/4885EBP 1300/4885 |
| US-20110166144-A1 | Pyrimidotriazinediones and Pyrimidopyrimidinediones and Methods of Using the Same | DPYD, TYMP, DHFR | KDM4E 4180/4885HRH3 3324/4885EBP 3660/4885 |
| US-20070213347-A1 | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents | AGER, S100A4, S100B | KDM4E 4138/4885HRH3 1008/4885EBP 2112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.