SCHEMBL1978269

SCHEMBL1978269

Cn1c(=O)c2[nH]c(CCCl)nc2n(C)c1=O

nearest known ligand 0.75

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.75
ALDH1A1 P00352 6/20 0.73
CYP3A4 P08684 3/20 0.73
HSD17B10 Q99714 2/20 0.64
CASP1 P29466 1/20 0.64
CASP7 P55210 1/20 0.64
CYP2C19 P33261 4/20 0.63
CYP1A2 P05177 1/20 0.63
ALOX15 P16050 1/20 0.57
MAPK1 P28482 1/20 0.57
CYP2D6 P10635 1/20 0.57
NR2F2 P24468 1/20 0.56
PABPC1 P11940 1/20 0.54
TSHR P16473 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10654293 0.90 ALDH1A1 (0.70) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL516379 0.86 POLB (1.00) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL21765989 0.86 POLB (0.77) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL3455612 0.84 POLB (0.75) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL22521846 0.84 ALDH1A1 (1.00) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL8664913 0.84 POLB (0.75) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL10421944 0.84 POLB (0.75) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL9406540 0.83 POLB (0.83) POLBALDH1A1CYP3A4HSD17B10CASP1
Hydrochloric Acid SCHEMBL8668067 0.83 POLB (0.73) POLBALDH1A1CYP3A4HSD17B10CASP1
SCHEMBL515773 0.82 POLB (0.77) POLBALDH1A1CYP3A4HSD17B10CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100280040-A1 SYNTHESIS AND PHARMACOKINETIC ACTIVITIES OF PULMODIL AND PULMODIL-1, TWO CHLOROPHENYLPIPERAZINE SALT DERIVATIVES KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-11-04 US claimed
EP-1466589-B1 Stable cosmetic composition comprising a fatty acid glyceride, an alcohol and a silicone emulsifier OREAL (FR) 2008-12-17 EP claimed
US-6710051-B1 SUBSTANCES IS A XANTHINE AND IS ADMINISTERED IN A DOSAGE OF 7.5-750 MG 1-4 TIMES DAILY TO TREAT MYOPIA KLAUS TRIER APS (DK) 2004-03-23 US claimed
US-20040013609-A1 For identification of substances for treatment or prevention of insufficient longitudinal growth of eye(hypermetropia) or excessive longitudinal growth of eye(myopia); involves measurement of effect on retinal pigment epithelium TRIER KLAUS (DK) 2004-01-22 US claimed
WO-1998030900-A2 SCREENING METHOD FOR COMPOUNDS ACTIVE IN TREATING MYOPIA AND HYPERMETROPIA KLAUS TRIER APS (DK) 1998-07-16 WO claimed
US-20190110977-A1 PROCESS FOR TREATMENT OF KERATINOUS MATERIALS AND KIT FOR FORMULATION OF A COSMETIC PRODUCT L'OREAL (FR) 2019-04-18 US disclosed
EP-2992885-A2 METHOD FOR INHIBITING A LIVER DISEASE Jansfat Biotechnology Co., Ltd. (TW) 2016-03-09 EP disclosed
CN-105380949-A Composition for treating high fat food induced liver lipopexia JANSFAT BIOTECHNOLOGY CO LTD 2016-03-09 CN disclosed
US-20150359901-A1 PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY JANSFAT BIOTECHNOLOGY CO., LTD. (TW) 2015-12-17 US disclosed
US-20150359798-A1 PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY JANSFAT BIOTECHNOLOGY CO., LTD. (TW) 2015-12-17 US disclosed
CN-102973566-B DPAs and high molecular polymer for hyperlipemia and reducing food intake amount and adipose tissue weight of obese animals CHEN YINGJUN (CN) 2015-10-07 CN disclosed
US-20150174157-A1 INHALED NO DONOR PIPERAZINYL DERIVATIVE PREVENTING ALLERGIC PULMONARY VASCULAR AND BRONCHIAL INFLAMMATION BY REDUCING VEGF AND RESTORING eNOS IN HYPOXIC PULMONARY ARTERY KAOHSIUNG MEDICAL UNIVERSITY (TW) 2015-06-25 US disclosed
US-20100280040-A1 SYNTHESIS AND PHARMACOKINETIC ACTIVITIES OF PULMODIL AND PULMODIL-1, TWO CHLOROPHENYLPIPERAZINE SALT DERIVATIVES KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-11-04 US disclosed
US-20100280041-A1 RHOKINASE-DEPENDENT INHIBITION ACTIVITY ON PULMONARY ARTERY ENDOTHELIUM DYSFUNCTION, MEDIAL WALL THICKNESS AND VASCULAR OBSTRUCTION OF PULMODIL AND PULMODIL-1 KAOHSIUNG MEDICAL UNIVERSITY (TW) 2010-11-04 US disclosed
WO-2009098139-A1 COSMETIC COMPOSITION CONTAINING A DIBENZOYLMETHANE DERIVATIVE AND A PARTICULAR NEUTRAL N-ACYLAMINO ACID ESTER DERIVATIVE; PROCESS FOR PHOTOSTABILIZING THE DIBENZOYLMETHANE DERIVATIVE L'OREAL (FR) 2009-08-13 WO disclosed
US-20080159970-A1 KIT COMPRISING SILICONE COMPOUNDS AND A COSMETIC AND/OR DERMATOLOGICAL ACTIVE AGENT L'OREAL (FR) 2008-07-03 US disclosed
US-20070297999-A1 KIT CONTAINING AN ACIDIC COMPOSITION AND A COMPOSITION BASED ON A HYDROXYALKYL UREA L'OREAL (FR) 2007-12-27 US disclosed
US-6710051-B1 SUBSTANCES IS A XANTHINE AND IS ADMINISTERED IN A DOSAGE OF 7.5-750 MG 1-4 TIMES DAILY TO TREAT MYOPIA KLAUS TRIER APS (DK) 2004-03-23 US disclosed
US-20040013609-A1 For identification of substances for treatment or prevention of insufficient longitudinal growth of eye(hypermetropia) or excessive longitudinal growth of eye(myopia); involves measurement of effect on retinal pigment epithelium TRIER KLAUS (DK) 2004-01-22 US disclosed
WO-1998030900-A2 SCREENING METHOD FOR COMPOUNDS ACTIVE IN TREATING MYOPIA AND HYPERMETROPIA KLAUS TRIER APS (DK) 1998-07-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100280040-A1 SYNTHESIS AND PHARMACOKINETIC ACTIVITIES OF PULMODIL AND PULMODIL-1, TWO CHLOROPHENYLPIPERAZINE SALT DERIVATIVES MCOLN1, AGTR1, CHRM1 POLB 2150/4885ALDH1A1 1756/4885CYP3A4 215/4885
US-20080159970-A1 KIT COMPRISING SILICONE COMPOUNDS AND A COSMETIC AND/OR DERMATOLOGICAL ACTIVE AGENT KRT18, CUTA, KIT POLB 1374/4885ALDH1A1 3150/4885CYP3A4 4788/4885
US-20190110977-A1 PROCESS FOR TREATMENT OF KERATINOUS MATERIALS AND KIT FOR FORMULATION OF A COSMETIC PRODUCT CUTA, KRT18, KIT POLB 19/4885ALDH1A1 1955/4885CYP3A4 4412/4885
US-20040013609-A1 For identification of substances for treatment or prevention of insufficient longitudinal growth of eye(hypermetropia) or excessive longitudinal growth of eye(myopia); involves measurement of effect on retinal pigment epithelium RYR1, ATP2A2, ATP2A1 POLB 3981/4885ALDH1A1 1550/4885CYP3A4 4148/4885
US-20100280041-A1 RHOKINASE-DEPENDENT INHIBITION ACTIVITY ON PULMONARY ARTERY ENDOTHELIUM DYSFUNCTION, MEDIAL WALL THICKNESS AND VASCULAR OBSTRUCTION OF PULMODIL AND PULMODIL-1 ROCK1, MYLK, PTGIR POLB 780/4885ALDH1A1 4001/4885CYP3A4 4031/4885
US-20150359798-A1 PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY FABP1, LIPC, PLIN5 POLB 644/4885ALDH1A1 371/4885CYP3A4 969/4885
US-20150359901-A1 PIPERAZINYL DERIVATIVE REDUCES HIGH-FAT DIET-INDUCED ACCUMULATION OF FAT IN THE LIVERS, THERAPEUTICALLY FABP1, LIPC, PLIN5 POLB 644/4885ALDH1A1 371/4885CYP3A4 969/4885
US-20070297999-A1 KIT CONTAINING AN ACIDIC COMPOSITION AND A COMPOSITION BASED ON A HYDROXYALKYL UREA CUTA, PRKDC, UNG POLB 72/4885ALDH1A1 1536/4885CYP3A4 4526/4885
US-20150174157-A1 INHALED NO DONOR PIPERAZINYL DERIVATIVE PREVENTING ALLERGIC PULMONARY VASCULAR AND BRONCHIAL INFLAMMATION BY REDUCING VEGF AND RESTORING eNOS IN HYPOXIC PULMONARY ARTERY NOS2, NOS3, NOS1 POLB 238/4885ALDH1A1 476/4885CYP3A4 438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.