Sugi Predict

Sugi Predict / Compounds / SCHEMBL2035484

SCHEMBL2035484

SCHEMBL2035484

O=C(O)c1c[nH]c2c(F)cccc12

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GPR84 Q9NQS5 1/20 0.53
▸ MPO P05164 5/20 0.53
▸ RAB9A P51151 1/20 0.52
▸ PCSK9 Q8NBP7 2/20 0.51
▸ KDM4E B2RXH2 2/20 0.50
▸ ALDH1A1 P00352 1/20 0.49
▸ HPGD P15428 1/20 0.49
▸ CSNK2A2 P19784 1/20 0.49
▸ CSNK2B P67870 1/20 0.49
▸ CSNK2A1 P68400 1/20 0.49
▸ SLC6A4 P31645 2/20 0.49
▸ BRPF1 P55201 1/20 0.49
▸ ALB P02768 1/20 0.48
▸ GUSB P08236 4/20 0.48
▸ DNA2 P51530 1/20 0.48
▸ CASP6 P55212 1/20 0.48
▸ CTDSP1 Q9GZU7 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2976084 0.90 CSNK2A2 (0.63) RAB9AKDM4EALDH1A1HPGDCSNK2A2
Hydrochloric Acid SCHEMBL31157465 0.89 CSNK2A2 (0.61) RAB9AKDM4EALDH1A1HPGDCSNK2A2
SCHEMBL1559436 0.88 RAB9A (0.49) GPR84MPORAB9APCSK9SLC6A4
SCHEMBL30909242 0.86 MPO (0.57) GPR84MPORAB9APCSK9ALDH1A1
SCHEMBL2037236 0.83 PIM3 (0.59) GPR84MPORAB9APCSK9SLC6A4
SCHEMBL28100554 0.83 GPR84 (0.51) GPR84MPORAB9APCSK9SLC6A4
SCHEMBL2811213 0.82 HTT (0.59) RAB9AKDM4EALDH1A1HPGDCSNK2A2
SCHEMBL29415445 0.82 HTT (0.59) RAB9AKDM4EALDH1A1HPGDCSNK2A2
SCHEMBL2034149 0.82 NR4A2 (0.70) GPR84MPORAB9APCSK9KDM4E
SCHEMBL7210602 0.79 NR4A2 (0.51) GPR84MPORAB9APCSK9BRPF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 — — EP disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
CN-117756785-A Preparation and application of N- (pyridine-2-yl) benzo [ b ] five-membered heterocycle-3-carboxamide structure compound 江西中医药大学 2024-03-26 — — CN disclosed
US-11891386-B2 Indole compounds and their use ARIAGEN, INC. (CA) 2024-02-06 — — US disclosed
CN-114380732-B Preparation method of fluoroindole carboxylic acid compound 上海毕得医药科技股份有限公司 2024-01-23 — — CN disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20230145074-A1 Indole Compounds and Their Use ARIAGEN, INC. (US) 2023-05-11 — — US disclosed
US-20230145249-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-05-11 — — US disclosed
US-20230145074-A1 Indole Compounds and Their Use ARIAGEN, INC. (US) 2023-05-11 — — US disclosed
WO-2020065613-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 — — WO disclosed
CN-105593211-A Indol and indazol derivatives HOFFMANN LA ROCHE 2016-05-18 — — CN disclosed
CN-102770425-A Indolyl-piperidinylbenzylamines as beta-tryptase inhibitors SANOFI SA 2012-11-07 — — CN disclosed
EP-2516419-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS SANOFI (FR) 2012-10-31 — — EP disclosed
US-20120245161-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS SANOFI (FR) 2012-09-27 — — US disclosed
US-20120245161-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS SANOFI (FR) 2012-09-27 — — US disclosed
US-20120245161-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS SANOFI (FR) 2012-09-27 — — US disclosed
WO-2011079102-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS SANOFI (FR) 2011-06-30 — — WO disclosed
WO-2011079102-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS SANOFI (FR) 2011-06-30 — — WO disclosed
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE ADDEX PHARMA SA (CH) 2010-09-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH GPR84 266/4885MPO 556/4885RAB9A 1784/4885
US-20100249123-A1 NOVEL BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE FSHR, GNRHR, SHBG GPR84 108/4885MPO 3170/4885RAB9A 1404/4885
US-20230145249-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP GPR84 162/4885MPO 538/4885RAB9A 936/4885
US-11891386-B2 Indole compounds and their use IDO1, IDO2, INMT GPR84 801/4885MPO 564/4885RAB9A 3025/4885
US-20120245161-A1 INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS TPSAB1, TPSB2, TPSD1 GPR84 589/4885MPO 431/4885RAB9A 1221/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP GPR84 162/4885MPO 538/4885RAB9A 936/4885
US-20230145074-A1 Indole Compounds and Their Use IDO1, IDO2, INMT GPR84 801/4885MPO 564/4885RAB9A 3025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.