Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | REN | P00797 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518741 | 0.90 | ALDH1A1 (0.62) | ALDH1A1NPSR1NPC1RAB9ALMNA | |
| SCHEMBL1128948 | 0.88 | NPC1 (0.64) | ALDH1A1NPSR1NPC1RAB9AREN | |
| SCHEMBL1128947 | 0.84 | ALDH1A1 (0.56) | ALDH1A1NPSR1NPC1RAB9AREN | |
| SCHEMBL3856362 | 0.83 | FDPS (0.42) | ALDH1A1NPSR1NPC1RAB9AREN | |
| SCHEMBL7135592 | 0.81 | NPC1 (0.79) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5031217 | 0.81 | YAP1 (0.46) | ALDH1A1LMNATDP1 | |
| SCHEMBL2939974 | 0.81 | ALOX5 (0.58) | ALDH1A1NPSR1NPC1RAB9AREN | |
| SCHEMBL4210846 | 0.80 | LMNA (0.53) | ALDH1A1NPSR1NPC1RAB9AREN | |
| SCHEMBL1386528 | 0.79 | LMNA (0.57) | ALDH1A1NPSR1NPC1RAB9AREN | |
| Carbamic Acid SCHEMBL6466030 | 0.79 | LMNA (0.57) | ALDH1A1NPSR1NPC1RAB9AREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3662089-A1 | METHOD FOR SEPARATING PALLADIUM FROM OTHER METAL ELEMENTS PRESENT IN AN AQUEOUS NITRIC PHASE USING SPECIFIC MALONAMIDES AS EXTRACTANTS | Commissariat à l'énergie atomique et aux énergies alternatives (FR) | 2020-06-10 | — | — | EP | claimed |
| EP-2030966-B1 | BENZYLIDENE MALONAMIDE AND SALT THEREOF, ULTRAVIOLET RAY ABSORBENT, AND AGENT FOR EXTERNAL APPLICATION TO THE SKIN | SHISEIDO CO LTD (JP) | 2013-01-02 | — | — | EP | claimed |
| CN-101472881-A | Benzylidene malonamide and salt thereof, ultraviolet ray absorbent, and agent for external application to the skin | SHISEIDO CO LTD (JP) | 2009-07-01 | — | — | CN | claimed |
| CN-118290285-A | Method for synthesizing amide | 中国石油化工股份有限公司 | 2024-07-05 | — | — | CN | disclosed |
| US-8841309-B2 | Substituted pyrazines and their use in the treatment of disease | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-20140088097-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-03-27 | — | — | US | disclosed |
| US-8158825-B2 | Modified malonate derivatives | MERCK SHARP & DOHME CORP. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100160327-A1 | Modified Malonate Derivatives | MERCK SHARP & DOHME LLC | 2010-06-24 | — | — | US | disclosed |
| CN-101472881-A | Benzylidene malonamide and salt thereof, ultraviolet ray absorbent, and agent for external application to the skin | SHISEIDO CO LTD (JP) | 2009-07-01 | — | — | CN | disclosed |
| WO-2007144981-A1 | BENZYLIDENE MALONAMIDE AND SALT THEREOF, ULTRAVIOLET RAY ABSORBENT, AND AGENT FOR EXTERNAL APPLICATION TO THE SKIN | SHISEIDO COMPANY, LTD. (JP) | 2007-12-21 | — | — | WO | disclosed |
| US-20040073038-A1 | Process of preparing paroxetine and intermediates for use therein | SPURCOURT LIMITED (GB) | 2004-04-15 | — | — | US | disclosed |
| EP-1362032-A2 | PROCESS OF PREPARING PAROXETINE AND INTERMEDIATES FOR USE THEREIN | Spurcourt Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002068416-A2 | PROCESS OF PREPARING PAROXETINE AND INTERMEDIATES FOR USE THEREIN | SPURCOURT LIMITED (GB) | 2002-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160327-A1 | Modified Malonate Derivatives | ME2, ME3, ME1 | ALDH1A1 784/4885NPSR1 4840/4885NPC1 4164/4885 |
| US-20140088097-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | SCNN1B, SCNN1A, TRPV1 | ALDH1A1 1172/4885NPSR1 1889/4885NPC1 690/4885 |
| US-20040073038-A1 | Process of preparing paroxetine and intermediates for use therein | CYP2D6, CYP2C19, CYP2B6 | ALDH1A1 602/4885NPSR1 259/4885NPC1 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.