SCHEMBL2108638

SCHEMBL2108638

COc1ccc(C(OC[C@@H]2O[C@H](n3ccc(=O)[nH]c3=O)C(OCOCCC#N)C2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.46
P2RY2 P41231 12/20 0.46
P2RY4 P51582 5/20 0.46
P2RY14 Q15391 4/20 0.46
P2RY12 Q9H244 1/20 0.40
P2RY6 Q15077 7/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2108637 1.00 TYMP (0.46) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL15841328 0.99 TYMP (0.45) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL19971896 0.99 TYMP (0.45) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL15841327 0.99 TYMP (0.45) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL3918341 0.96 TYMP (0.48) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL13715991 0.96 TYMP (0.48) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL3918343 0.96 TYMP (0.48) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL15261068 0.90 TYMP (0.48) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL15260893 0.90 TYMP (0.48) TYMPP2RY2P2RY4P2RY14P2RY12
SCHEMBL2116483 0.89 TYMP (0.47) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509485-B2 Method for producing nucleic acid oligomer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2025-12-30 US disclosed
US-20250145655-A1 METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2025-05-08 US disclosed
EP-4488282-A1 METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER Sumitomo Chemical Company, Limited (JP) 2025-01-08 EP disclosed
US-20240051986-A1 METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2024-02-15 US disclosed
EP-4219520-A1 METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2023-08-02 EP disclosed
EP-1995253-B1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID NIPPON SHINYAKU CO LTD (JP) 2016-12-21 EP disclosed
US-8859755-B2 Method for preparing ribonucleoside phosphorothioate CHIRALGEN, LTD. (JP) 2014-10-14 US disclosed
US-20130184450-A1 METHOD FOR PREPARING RIBONUCLEOSIDE PHOSPHOROTHIOATE THE UNIVERSITY OF TOKYO (JP) 2013-07-18 US disclosed
EP-1795536-B1 PHOSPHORAMIDITE COMPOUND AND METHOD FOR PRODUCING OLIGO-RNA NIPPON SHINYAKU CO LTD (JP) 2012-05-02 EP disclosed
US-8158775-B2 Method for detaching protecting group on nucleic acid NIPPON SHINYAKU CO., LTD. (JP) 2012-04-17 US disclosed
US-20090312534-A1 METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP NIPPON SHINYAKU CO., LTD. (JP) 2009-12-17 US disclosed
US-20090149645-A1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID NIPPON SHINYAKU CO., LTD. (JP) 2009-06-11 US disclosed
US-20090137790-A1 METHOD OF CAPPING OLIGONUCLEIC ACID NIPPON SHINYAKU CO., LTD. (JP) 2009-05-28 US disclosed
EP-2017282-A1 METHOD OF CAPPING OLIGONUCLEIC ACID Nippon Shinyaku Co., Ltd. (JP) 2009-01-21 EP disclosed
EP-1995252-A1 METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP Nippon Shinyaku Co., Ltd. (JP) 2008-11-26 EP disclosed
EP-1995253-A1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID Nippon Shinyaku Co., Ltd. (JP) 2008-11-26 EP disclosed
US-20070282097-A1 Phosphoramidite Compound And Method For Producing Oligo-Rna NIPPON SHINYAKU CO., LTD. (JP) 2007-12-06 US disclosed
EP-1795536-A1 PHOSPHORAMIDITE COMPOUND AND METHOD FOR PRODUCING OLIGO-RNA Nippon Shinyaku Co., Ltd. (JP) 2007-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250145655-A1 METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER POLRMT, RNGTT, POLM TYMP 458/4885P2RY2 2861/4885P2RY4 2389/4885
US-20240051986-A1 METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER POLRMT, NOP2, POLN TYMP 689/4885P2RY2 3439/4885P2RY4 2080/4885
US-20090312534-A1 METHOD FOR REMOVAL OF NUCLEIC ACID-PROTECTING GROUP NSUN2, RNASEH1, RNASE1 TYMP 321/4885P2RY2 4819/4885P2RY4 4822/4885
US-20090137790-A1 METHOD OF CAPPING OLIGONUCLEIC ACID RNGTT, DUT, ADAR TYMP 122/4885P2RY2 1513/4885P2RY4 1416/4885
US-12509485-B2 Method for producing nucleic acid oligomer RNGTT, POLM, NSUN2 TYMP 365/4885P2RY2 2712/4885P2RY4 1915/4885
US-20070282097-A1 Phosphoramidite Compound And Method For Producing Oligo-Rna NSUN2, NSUN3, XRN2 TYMP 485/4885P2RY2 1095/4885P2RY4 2054/4885
US-20130184450-A1 METHOD FOR PREPARING RIBONUCLEOSIDE PHOSPHOROTHIOATE RNGTT, RNMT, TRDMT1 TYMP 116/4885P2RY2 3157/4885P2RY4 2112/4885
US-20090149645-A1 METHOD FOR DETACHING PROTECTING GROUP ON NUCLEIC ACID DNASE1, DNASE1L3, NSUN2 TYMP 149/4885P2RY2 4225/4885P2RY4 4243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.