SCHEMBL2124592

SCHEMBL2124592

COC(=O)C(C(=O)/C=C/c1ccccc1O)C(=O)/C=C/c1ccccc1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.59
MMP9 P14780 2/20 0.59
MMP13 P45452 2/20 0.59
MAPT P10636 4/20 0.56
LMNA P02545 1/20 0.56
MMP8 P22894 1/20 0.55
NFKB1 P19838 2/20 0.54
NFE2L2 Q16236 2/20 0.54
JUN P05412 1/20 0.54
MAPK1 P28482 2/20 0.54
KDM4E B2RXH2 1/20 0.54
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
ATM Q13315 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA4 P22748 1/20 0.53
MAOB P27338 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30541005 0.81 MMP13 (0.51) MMP2MMP9MMP13MAPTLMNA
SCHEMBL2123263 0.80 BACE1 (0.57) MMP2MMP9MMP13MAPTLMNA
SCHEMBL19851474 0.79 MMP2 (0.61) MMP2MMP9MMP13MAPTMMP8
SCHEMBL10084348 0.79 MMP2 (0.73) MMP2MMP9MMP13MAPTLMNA
SCHEMBL25142238 0.78 MAPT (0.65) MAPTLMNANFKB1NFE2L2JUN
SCHEMBL63054 0.78 MAPT (0.65) MAPTLMNANFKB1NFE2L2JUN
SCHEMBL29362833 0.78 MAPT (0.65) MAPTLMNANFKB1NFE2L2JUN
SCHEMBL63055 0.78 MAPT (0.65) MAPTLMNANFKB1NFE2L2JUN
SCHEMBL2124084 0.74 MMP2 (1.00) MMP2MMP9MMP13MAPTMMP8
SCHEMBL2123091 0.74 MMP2 (0.70) MMP2MMP9MMP13MMP8MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240360068-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-10-31 US disclosed
US-20230265041-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-08-24 US disclosed
US-20230265041-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-08-24 US disclosed
US-11608309-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2023-03-21 US disclosed
US-20210322346-A1 CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-10-21 US disclosed
US-20210053905-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-02-25 US disclosed
US-20210053905-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-02-25 US disclosed
US-10669227-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2020-06-02 US disclosed
US-10669227-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2020-06-02 US disclosed
US-20190254945-A1 INHIBITION OF MELANOGENESIS BY CHEMICALLY MODIFIED CURCUMINS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2019-08-22 US disclosed
US-9187406-B2 Curcumin analogues as zinc chelators and their uses THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2015-11-17 US disclosed
US-20150150834-A1 POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES CHEM-MASTER INTERNATIONAL, INC. (US) 2015-06-04 US disclosed
US-20150150834-A1 POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES CHEM-MASTER INTERNATIONAL, INC. (US) 2015-06-04 US disclosed
US-20150073021-A1 CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2015-03-12 US disclosed
US-20150073021-A1 CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2015-03-12 US disclosed
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES CHEM-MASTER INTERNATIONAL, INC. 2012-04-19 US disclosed
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES CHEM-MASTER INTERNATIONAL, INC. 2012-04-19 US disclosed
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES CHEM-MASTER INTERNATIONAL, INC. 2012-04-19 US disclosed
WO-2010132815-A9 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2011-01-13 WO disclosed
WO-2010132815-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) 2010-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150073021-A1 CHEMICALLY MODIFIED CURCUMINS AS INHIBITORS OF ANTHRAX LETHAL FACTOR ANTXR2, APAF1, LITAF MMP2 224/4885MMP9 1104/4885MMP13 928/4885
US-20230265041-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES NFRKB, NFKBIA, NFKB1 MMP2 32/4885MMP9 17/4885MMP13 12/4885
US-20120095051-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-10669227-B2 Curcumin analogues as zinc chelators and their uses NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20150150834-A1 POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES BAZ2B, CEBPZ, BAZ2A MMP2 2518/4885MMP9 1634/4885MMP13 886/4885
US-11608309-B2 Curcumin analogues as zinc chelators and their uses NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20210053905-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20190254945-A1 INHIBITION OF MELANOGENESIS BY CHEMICALLY MODIFIED CURCUMINS TYR, MC1R, MITF MMP2 1633/4885MMP9 1649/4885MMP13 628/4885
US-20240360068-A1 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES NFKBIA, NFKB1, NFKB2 MMP2 19/4885MMP9 12/4885MMP13 11/4885
US-20210322346-A1 CHEMICALLY MODIFIED CURCUMINS FOR USE IN THE PRODUCTION OF LIPOXINS ALOX15B, ALOX15, ALOX12 MMP2 691/4885MMP9 1330/4885MMP13 483/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.