Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Isopropyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropyl Alcohol SCHEMBL4337774 | 0.95 | ALDH1A1 (0.60) | ALDH1A1LMNATSHRTDP1 | |
| Isopropyl Alcohol SCHEMBL6554536 | 0.95 | — | — | |
| Isopropyl Alcohol SCHEMBL5858313 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNATSHRTDP1 | |
| Isopropyl Alcohol SCHEMBL27497569 | 0.91 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRTDP1 | |
| Isopropyl Alcohol SCHEMBL5999087 | 0.91 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRTDP1 | |
| Isopropyl Alcohol SCHEMBL7671116 | 0.91 | ALDH1A1 (0.67) | ALDH1A1LMNATSHRTDP1 | |
| Isopropyl Alcohol SCHEMBL52447 | 0.91 | — | — | |
| Isopropyl Alcohol SCHEMBL1150321 | 0.86 | — | — | |
| Chloroform SCHEMBL9617984 | 0.85 | LMNA (0.50) | ALDH1A1LMNATSHRTDP1 | |
| Chloroform SCHEMBL25447 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103044424-B | A kind of method of matrine in enriching and purifying kuh-seng | Daxing'an Mountainrange Lin Gebei psychrophile Science and Technology Co., Ltd. (CN) | 2015-12-02 | — | — | CN | claimed |
| CN-103044424-B | A kind of method of matrine in enriching and purifying kuh-seng | Daxing'an Mountainrange Lin Gebei psychrophile Science and Technology Co., Ltd. (CN) | 2015-12-02 | — | — | CN | disclosed |
| CN-102060677-B | Method for enriching and purifying eugenol in Chinese pink herb | DAXINGANLING GADOL SPORTS INGREDIENT CO LTD | 2013-06-05 | — | — | CN | disclosed |
| US-8324177-B2 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2012-12-04 | — | — | US | disclosed |
| US-20110294752-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 2011-12-01 | — | — | US | disclosed |
| EP-1079824-B1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | RES DEV FOUNDATION (US) | 2011-08-31 | — | — | EP | disclosed |
| US-7985435-B2 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2011-07-26 | — | — | US | disclosed |
| US-20100189824-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | ARNTZEN CHARLES J | 2010-07-29 | — | — | US | disclosed |
| EP-1355642-A4 | INHIBITION OF NF-(k)B BY TRITERPENE COMPOSITIONS | RES DEV FOUNDATION (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20060148732-A1 | Inhibition of NF-kappaB by triterpene compositions | RESEARCH DEVELOPMENT FOUNDATION | 2006-07-06 | — | — | US | disclosed |
| US-6962720-B2 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2005-11-08 | — | — | US | disclosed |
| US-6746696-B2 | ANTITUMOR AGENTS; APOPTOSIS | RESEARCH DEVELOPMENT FOUNDATION | 2004-06-08 | — | — | US | disclosed |
| US-6689398-B2 | CONTROLLING APOPTOSIS; ANTITUMOR AGENT; GLYCYRRHETINIC ACID MIXTURES | RESEARCH DEVELOPMENT FOUNDATION | 2004-02-10 | — | — | US | disclosed |
| EP-1355642-A2 | INHIBITION OF NF-(k)B BY TRITERPENE COMPOSITIONS | RESEARCH DEVELOPMENT FOUNDATION (US) | 2003-10-29 | — | — | EP | disclosed |
| US-20030054052-A1 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION | 2003-03-20 | — | — | US | disclosed |
| US-20030039705-A1 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION | 2003-02-27 | — | — | US | disclosed |
| US-20030031738-A1 | Triterpene compositions and methods for use thereof | RESEARCH DEVELOPMENT FOUNDATION (US) | 2003-02-13 | — | — | US | disclosed |
| US-6444233-B1 | ANTITUMOR AGENTS | RESEARCH DEVELOPMENT FOUNDATION | 2002-09-03 | — | — | US | disclosed |
| WO-2002055016-A2 | INHIBITION OF NF-λB BY TRITERPENE COMPOSITIONS | RES DEV FOUNDATION (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294752-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | OSTC, ACACA, NFATC1 | ALDH1A1 2759/4885LMNA 419/4885TSHR 3986/4885 |
| US-20100189824-A1 | TRITERPENE COMPOSITIONS AND METHODS FOR USE THEREOF | OSTC, ACACA, NFATC1 | ALDH1A1 2759/4885LMNA 419/4885TSHR 3986/4885 |
| US-20030031738-A1 | Triterpene compositions and methods for use thereof | OSTC, ACACA, NFATC1 | ALDH1A1 2759/4885LMNA 419/4885TSHR 3986/4885 |
| US-20030039705-A1 | Triterpene compositions and methods for use thereof | BAX, CASP3, ACACA | ALDH1A1 2361/4885LMNA 213/4885TSHR 3311/4885 |
| US-20060148732-A1 | Inhibition of NF-kappaB by triterpene compositions | NFKBIA, NFKB2, RELA | ALDH1A1 1797/4885LMNA 419/4885TSHR 4781/4885 |
| US-20030054052-A1 | Triterpene compositions and methods for use thereof | OSTC, ACACA, NFATC1 | ALDH1A1 2759/4885LMNA 419/4885TSHR 3986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.