SCHEMBL21753489

SCHEMBL21753489

CCc1c(CCl)ccc(-c2ccccc2)c1CC

nearest known ligand 0.34

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 4/20 0.34
PDCD1 Q15116 1/20 0.34
CD274 Q9NZQ7 1/20 0.34
GCGR P47871 1/20 0.34
USP7 Q93009 2/20 0.34
CYP2A6 P11509 1/20 0.33
DPP8 Q6V1X1 1/20 0.33
CSNK2A1 P68400 2/20 0.33
TP53 P04637 1/20 0.32
ESR2 Q92731 2/20 0.32
ESR1 P03372 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32
SLC5A2 P31639 1/20 0.31
CTRC Q99895 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL473259 0.86 DPP4 (0.38) DPP4PDCD1CD274GCGRUSP7
Water SCHEMBL474768 0.85 DPP4 (0.37) DPP4PDCD1CD274GCGRUSP7
SCHEMBL28126300 0.82 DPP4 (0.38) DPP4PDCD1CD274CYP2A6DPP8
SCHEMBL9185899 0.80 TP53 (0.40) TP53SLC5A2
SCHEMBL6917622 0.79 CTRC (0.34) CTRC
Ether SCHEMBL474769 0.79 ADORA3 (0.35) DPP4PDCD1CD274GCGRUSP7
Aziridine SCHEMBL11855718 0.79 HTR6 (0.38)
SCHEMBL11207750 0.79 TP53 (0.39) TP53SLC5A2
SCHEMBL9504989 0.77 GABRA1 (0.36) DPP4PDCD1CD274GCGRUSP7
SCHEMBL2494174 0.75 CTRC (0.37) ALDH1A1TSHRCTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624355-B2 Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method thereof and use thereof Suzhou Ribo Life Science Co., Ltd. (CN) 2026-05-12 US disclosed
US-12428642-B2 Nucleic acid, composition and conjugate comprising the same, preparation method and use thereof Suzhou Ribo Life Science Co., Ltd. (CN) 2025-09-30 US disclosed
US-12274752-B2 Nucleic acid, composition and conjugate containing same, preparation method, and use thereof Suzhou Ribo Life Science Co., Ltd. (CN) 2025-04-15 US disclosed
EP-4527459-A2 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, PREPARATION METHOD THEREFOR AND USE THEREOF Suzhou Ribo Life Science Co., Ltd. (CN) 2025-03-26 EP disclosed
EP-3732185-B1 CONJUGATES AND PREPARATION AND USE THEREOF SUZHOU RIBO LIFE SCIENCE CO LTD (CN) 2025-02-26 EP disclosed
EP-3719128-B1 DOUBLE-STRANDED OLIGONUCLEOTIDE, COMPOSITION AND CONJUGATE COMPRISING DOUBLE-STRANDED OLIGONUCLEOTIDE, PREPARATION METHOD THEREFOR AND USE THEREOF SUZHOU RIBO LIFE SCIENCE CO LTD (CN) 2025-01-15 EP disclosed
EP-3719125-B1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE SUZHOU RIBO LIFE SCIENCE CO LTD (CN) 2025-01-08 EP disclosed
EP-3719126-B1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, PREPARATION METHOD THEREFOR AND USE THEREOF SUZHOU RIBO LIFE SCIENCE CO LTD (CN) 2025-01-01 EP disclosed
US-20240382514-A1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE THEREOF Suzhou Ribo Life Science Co., Ltd. (CN) 2024-11-21 US disclosed
EP-4455285-A2 NUCLEIC ACID, COMPOSITION AND CONJUGATE COMPRISING THE SAME, AND PREPARATION METHOD AND USE THEREOF Suzhou Ribo Life Science Co., Ltd. (CN) 2024-10-30 EP disclosed
CN-111050807-A Nucleic acid, composition containing nucleic acid, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-04-21 CN disclosed
CN-110997919-A Double-stranded oligonucleotide, composition containing double-stranded oligonucleotide, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-04-10 CN disclosed
CN-110997917-A Nucleic acid, composition containing nucleic acid, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-04-10 CN disclosed
CN-110959011-A Conjugate, preparation method and application thereof 苏州瑞博生物技术有限公司 2020-04-03 CN disclosed
WO-2020063198-A1 SIRNA CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF 苏州瑞博生物技术有限公司 2020-04-02 WO disclosed
CN-110944675-A Nucleic acid, composition containing nucleic acid, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-03-31 CN disclosed
CN-110945130-A Nucleic acid, composition containing nucleic acid, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-03-31 CN disclosed
CN-110945132-A Nucleic acid, composition containing nucleic acid, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-03-31 CN disclosed
CN-110945131-A Nucleic acid, composition containing nucleic acid, conjugate, preparation method and application 苏州瑞博生物技术有限公司 2020-03-31 CN disclosed
WO-2020038377-A1 NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE CONTAINING NUCLEIC ACID, AND USE THEREOF 苏州瑞博生物技术有限公司 2020-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12624355-B2 Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method thereof and use thereof RNGTT, RNMT, NSUN2 DPP4 2441/4885PDCD1 4632/4885CD274 4763/4885
US-12274752-B2 Nucleic acid, composition and conjugate containing same, preparation method, and use thereof APOB, C1QBP, APOL1 DPP4 2831/4885PDCD1 4729/4885CD274 4766/4885
US-20240382514-A1 NUCLEIC ACID, COMPOSITION AND CONJUGATE CONTAINING SAME, AND PREPARATION METHOD AND USE THEREOF RNGTT, NSUN2, ADAR DPP4 4482/4885PDCD1 4039/4885CD274 3696/4885
US-12428642-B2 Nucleic acid, composition and conjugate comprising the same, preparation method and use thereof TEK, TIE1, IGF2BP3 DPP4 3129/4885PDCD1 3307/4885CD274 2867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.