SCHEMBL2235852

SCHEMBL2235852

Clc1cccc(-c2[c]ccs2)c1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.40
ESR2 Q92731 1/20 0.40
ALOX5 P09917 1/20 0.39
TAAR1 Q96RJ0 1/20 0.38
CYP19A1 P11511 1/20 0.36
RORB Q92753 1/20 0.36
NOTUM Q6P988 4/20 0.36
NPC1 O15118 1/20 0.36
TP53 P04637 1/20 0.36
TSHR P16473 1/20 0.36
NFKB1 P19838 1/20 0.36
RAB9A P51151 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
IDO1 P14902 4/20 0.35
MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3789321 0.78 MAOA (0.45) BRD4NPC1TP53TSHRNFKB1
SCHEMBL28253383 0.78 RAB9A (0.41) NPC1TP53TSHRRAB9ASMN1; SMN2
SCHEMBL2236313 0.78 KDM4E (0.41) ESR2TAAR1NOTUMTP53SMN1; SMN2
SCHEMBL4591149 0.76 CASP3 (0.38) NOTUMNPC1RAB9ASMN1; SMN2IDO1
SCHEMBL28209751 0.70 CYP2E1 (0.32) NPC1TP53NFKB1RAB9ANFKB2
SCHEMBL31222672 0.70 ALOX5 (0.65) ESR2ALOX5TAAR1NOTUMNPC1
SCHEMBL817554 0.70 ALOX5 (0.65) ESR2ALOX5TAAR1NOTUMNPC1
Hydrochloric Acid SCHEMBL31070804 0.67 ALOX5 (0.62) ESR2ALOX5TAAR1NOTUMNPC1
SCHEMBL29629014 0.67 ALOX5 (0.62) ESR2ALOX5TAAR1NOTUMNPC1
Hydrochloric Acid SCHEMBL28332867 0.67 ALOX5 (0.62) ESR2ALOX5TAAR1NOTUMNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115702174-B Production of polypropylene with low volatiles 博里利斯股份公司 2024-05-14 CN disclosed
CN-115315451-B Catalyst for olefin polymerization, method for producing catalyst for olefin polymerization, and method for producing olefin polymer using catalyst for olefin polymerization 日本聚丙烯株式会社 2023-12-01 CN disclosed
US-20230331881-A1 PRODUCTION OF POLYPROPYLENE WITH LOW VOLATILES BOREALIS AG (AT) 2023-10-19 US disclosed
CN-114616280-B Heterophasic propylene ethylene copolymer compositions with desirable balance of mechanical properties 北欧化工公司 2023-10-13 CN disclosed
US-20230142911-A1 OLEFIN POLYMERIZATION CATALYST, OLEFIN POLYMERIZATION CATALYST PRODUCTION METHOD, AND OLEFIN POLYMER PRODUCTION METHOD USING THE OLEFIN POLYMERIZATION CATALYST JAPAN POLYPROPYLENE CORPORATION (JP) 2023-05-11 US disclosed
CN-115702174-A Production of polypropylene with low volatiles 博里利斯股份公司 2023-02-14 CN disclosed
EP-4105246-A1 CATALYST FOR OLEFIN POLYMERIZATION, PRODUCTION METHOD FOR CATALYST FOR OLEFIN POLYMERIZATION, AND PRODUCTION METHOD FOR OLEFIN POLYMER USING SAID CATALYST FOR OLEFIN POLYMERIZATION Japan Polypropylene Corporation (JP) 2022-12-21 EP disclosed
US-20220396695-A1 HETEROPHASIC PROPYLENE ETHYLENE COPOLYMER COMPOSITION WITH DESIRABLE BALANCE OF MECHANICAL PROPERTIES BOREALIS AG (AT) 2022-12-15 US disclosed
CN-115315451-A Olefin polymerization catalyst, method for producing olefin polymerization catalyst, and method for producing olefin polymer using olefin polymerization catalyst 日本聚丙烯株式会社 2022-11-08 CN disclosed
CN-114616280-A Heterophasic propylene ethylene copolymer compositions having a desirable balance of mechanical properties 北欧化工公司 2022-06-10 CN disclosed
US-20170081431-A1 METALLOCENE COMPLEX AND METHOD FOR PRODUCING OLEFIN POLYMER JAPAN POLYPROPYLENE CORPORATION (JP) 2017-03-23 US disclosed
EP-3121187-A1 METALLOCENE COMPLEX AND METHOD FOR MANUFACTURING OLEFIN POLYMER Japan Polypropylene Corporation (JP) 2017-01-25 EP disclosed
CN-106132975-A metallocene complex and process for producing olefin polymer 日本聚丙烯株式会社 2016-11-16 CN disclosed
US-20150266914-A1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD JAPAN POLYPROPYLENE CORPORATION (JP) 2015-09-24 US disclosed
CN-104781270-A Metallocene complexes and olefin polymerization process JAPAN POLYPROPYLENE CORP 2015-07-15 CN disclosed
EP-2360163-B1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN JAPAN POLYPROPYLENE CORP (JP) 2014-06-25 EP disclosed
US-8461365-B2 Metallocene complex and polymerization method of olefin JAPAN POLYPROPYLENE CORPORATION (JP) 2013-06-11 US disclosed
CN-102245620-A Metallocene complex and method for polymerizing olefin JAPAN POLYPROPYLENE CORP 2011-11-16 CN disclosed
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN JAPAN POLYPROPYLENE CORPORATION (JP) 2011-09-22 US disclosed
EP-2360163-A1 METALLOCENE COMPLEX AND METHOD FOR POLYMERIZING OLEFIN Japan Polypropylene Corporation (JP) 2011-08-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230622-A1 METALLOCENE COMPLEX AND POLYMERIZATION METHOD OF OLEFIN ALOX12, ALOX15, ALOX15B BRD4 2500/4885ESR2 194/4885ALOX5 31/4885
US-20170081431-A1 METALLOCENE COMPLEX AND METHOD FOR PRODUCING OLEFIN POLYMER PPOX, ALOX12, PORCN BRD4 2823/4885ESR2 2182/4885ALOX5 26/4885
US-20150266914-A1 METALLOCENE COMPLEX AND OLEFIN POLYMERIZATION METHOD POR, OPRM1, ALOX12 BRD4 3441/4885ESR2 236/4885ALOX5 163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.