Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042605 | 0.91 | KDM4E (0.37) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL29284805 | 0.77 | KDM4E (0.48) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL9324224 | 0.75 | TSHR (0.40) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL3905800 | 0.74 | KDM4E (0.40) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL489664 | 0.72 | MAPT (0.50) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL1567065 | 0.72 | SMN1; SMN2 (0.40) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL3905041 | 0.72 | SMN1; SMN2 (0.40) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL214687 | 0.71 | KDM4E (0.62) | KDM4EMAPTALOX15ALDH1A1TSHR | |
| SCHEMBL1167764 | 0.71 | PTGS1 (0.43) | LMNA | |
| SCHEMBL3678949 | 0.69 | GMNN (0.38) | KDM4EMAPTALOX15ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 345 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985527-A | IMAGES AND DYE DEVELOPMENT | FUJI PHOTO FILM CO., LTD. (JP) | 1999-11-16 | — | — | US | claimed |
| US-20230144767-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-05-11 | — | — | US | disclosed |
| US-20210371460-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-12-02 | — | — | US | disclosed |
| US-20200317730-A1 | TARGETED NITROXIDE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-10-08 | — | — | US | disclosed |
| US-10751273-B2 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190210969-A1 | INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-07-11 | — | — | US | disclosed |
| US-20180298054-A1 | TARGETED NITROXIDE AGENTS | University of Pittsburgh - of the Commonwealth Sys tem of Higher Education (US) | 2018-10-18 | — | — | US | disclosed |
| US-9890192-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2018-02-13 | — | — | US | disclosed |
| US-9732105-B2 | Targeted nitroxide agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160151269-A1 | COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-06-02 | — | — | US | disclosed |
| EP-0595312-A1 | Automatic processing machine for silver halide photographic light-sensitive materials | KONICA CORPORATION (JP) | 1994-05-04 | — | — | EP | disclosed |
| EP-0591934-A1 | Photographic processing composition and processing method | FUJI PHOTO FILM CO., LTD. (JP) | 1994-04-13 | — | — | EP | disclosed |
| EP-0573761-A1 | Method of forming coloured images | FUJI PHOTO FILM CO., LTD. (JP) | 1993-12-15 | — | — | EP | disclosed |
| EP-0569852-A1 | Bleach-fixing composition for color photographic material and method for processing a color photographic material with the same | Fuji Photo Film Co., Ltd. (JP) | 1993-11-18 | — | — | EP | disclosed |
| EP-0565023-A1 | Method for processing silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1993-10-13 | — | — | EP | disclosed |
| EP-0557851-A1 | Method for processing color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| EP-0545301-A1 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |
| EP-0544322-A1 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1993-06-02 | — | — | EP | disclosed |
| EP-0532042-A1 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |
| EP-0530828-A1 | Photographic processing composition and processing method | FUJI PHOTO FILM CO., LTD. (JP) | 1993-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190210969-A1 | INTRAESOPHAGEAL ADMINISTRATION OF TARGETED NITROXIDE AGENTS FOR PROTECTION AGAINST IONIZING IRRADIATION-INDUCED ESOPHAGITIS | HSPE1, HSPA9, HSPD1 | KDM4E 4100/4885MAPT 3025/4885ALOX15 1688/4885 |
| US-20160151269-A1 | COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS | GLA, AGER, SIRT1 | KDM4E 3331/4885MAPT 143/4885ALOX15 626/4885 |
| US-20180298054-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | KDM4E 2171/4885MAPT 1583/4885ALOX15 1843/4885 |
| US-20200317730-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | KDM4E 2171/4885MAPT 1583/4885ALOX15 1843/4885 |
| US-10751273-B2 | Compounds for the treatment of pathologies associated with aging and degenerative disorders | GLA, AGER, SIRT1 | KDM4E 3331/4885MAPT 143/4885ALOX15 626/4885 |
| US-20230144767-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | KDM4E 2171/4885MAPT 1583/4885ALOX15 1843/4885 |
| US-20210371460-A1 | TARGETED NITROXIDE AGENTS | TXNRD2, TXN2, HSPE1 | KDM4E 2171/4885MAPT 1583/4885ALOX15 1843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.