Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B known ✓ | P29275 | 6/20 | 0.36 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.35 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.34 |
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.33 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.33 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17565779 | 0.79 | ALDH1A1 (0.50) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| SCHEMBL3171668 | 0.77 | CA12 (0.52) | LMNATDP1CA12CA2CA9 | |
| SCHEMBL5846996 | 0.77 | CA12 (0.52) | LMNATDP1CA12CA2CA9 | |
| SCHEMBL19953365 | 0.74 | LMNA (0.55) | ALDH1A1GAAPOLBLMNATDP1 | |
| SCHEMBL7090696 | 0.73 | CA2 (0.66) | KDM4EPLA2G10ALDH1A1GAAHPGD | |
| Potassium Ion SCHEMBL9302660 | 0.71 | CA12 (0.52) | LMNATDP1CA12CA2CA9 | |
| Potassium Ion SCHEMBL5847292 | 0.71 | CA12 (0.52) | LMNATDP1CA12CA2CA9 | |
| SCHEMBL11355036 | 0.69 | GAA (0.54) | ALDH1A1GAAPOLB | |
| SCHEMBL8662029 | 0.69 | CA12 (0.60) | KDM4EALDH1A1GAAPTGS2CA12 | |
| SCHEMBL28934944 | 0.68 | LMNA (0.48) | ALDH1A1GAALMNATDP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227099-B1 | PROCESS FOR PRODUCING TYRES PROVIDED WITH AUXILIARY COMPONENTS AND TYRE HAVING AN AUXILIARY COMPONENT | PIRELLI (IT) | 2020-11-18 | — | — | EP | disclosed |
| CN-107000347-B | Method for producing a tyre with auxiliary components and tyre with auxiliary components | 倍耐力轮胎股份公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-107000347-A | Method for producing a tyre with auxiliary components and tyre with auxiliary components | 倍耐力轮胎股份公司 | 2017-08-01 | — | — | CN | disclosed |