Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.70 |
| ▸ | HLCS | P50747 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | IDE | P14735 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | CNR1 | P21554 | 2/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13621820 | 1.00 | TDP1 (0.70) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL13624959 | 1.00 | TDP1 (0.70) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL14600797 | 1.00 | TDP1 (0.70) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL12085208 | 1.00 | TDP1 (0.70) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL17704089 | 0.97 | TDP1 (0.72) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL8240579 | 0.97 | TDP1 (0.72) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL6941477 | 0.97 | TDP1 (0.72) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL15870672 | 0.95 | HLCS (0.71) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL22493325 | 0.95 | HLCS (0.71) | TDP1HLCSMEN1ABL1LMNA | |
| SCHEMBL12320610 | 0.95 | HLCS (0.71) | TDP1HLCSMEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028321-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-01-26 | — | — | US | disclosed |
| US-10905665-B2 | Chemical modulators of signaling pathways and therapeutic use | DUKE UNIVERSITY (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200038350-A1 | CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE | DUKE UNIVERSITY | 2020-02-06 | — | — | US | disclosed |
| US-20190125882-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2019-05-02 | — | — | US | disclosed |
| US-10179175-B2 | Isatoic anhydride derivatives and applications thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2019-01-15 | — | — | US | disclosed |
| US-20180179572-A1 | Methods for Rapid Antimicrobial Susceptibility Testing | OXFORD FINANCE LLC | 2018-06-28 | — | — | US | disclosed |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2018-04-26 | — | — | US | disclosed |
| US-9867883-B2 | Isatoic anhydride derivatives and applications thereof | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2018-01-16 | — | — | US | disclosed |
| US-9834808-B2 | Methods for rapid antibiotic susceptibility testing | SeLux Diagnostics, Inc. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170211121-A1 | Methods for Rapid Antibiotic Susceptibility Testing | OXFORD FINANCE LLC | 2017-07-27 | — | — | US | disclosed |
| US-20170035893-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2017-02-09 | — | — | US | disclosed |
| US-8133694-B2 | Analyzing metabolites, binding proteins; cyanoalkylation; competitive binding; immunoassay; kits | IMMUNDIAGNOSTIK AG (DE) | 2012-03-13 | — | — | US | disclosed |
| US-8133694-B2 | Analyzing metabolites, binding proteins; cyanoalkylation; competitive binding; immunoassay; kits | IMMUNDIAGNOSTIK AG (DE) | 2012-03-13 | — | — | US | disclosed |
| US-8124767-B2 | Luminescence biotin-transition metal complex conjugate, and method of amplifying signal using the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2012-02-28 | — | — | US | disclosed |
| US-20110319293-A1 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY | LIFESENSORS, INC. | 2011-12-29 | — | — | US | disclosed |
| EP-1483583-B1 | ACYL FLUORIDE ACTIVATION OF CARBOXYSILYL-COATED GLASS SUBSTRATES | BECKMAN COULTER INC (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2009134942-A1 | ASSAY FOR PATHOGENIC CONFORMERS | NOVARTIS AG. (CH) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179175-B2 | Isatoic anhydride derivatives and applications thereof | AASDHPPT, CA13, CA12 | TDP1 2667/4885HLCS 1260/4885MEN1 3892/4885 |
| US-20190125882-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | TDP1 2667/4885HLCS 1260/4885MEN1 3892/4885 |
| US-20200038350-A1 | CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE | SFRP1, FZD7, WNT1 | TDP1 4810/4885HLCS 2454/4885MEN1 3144/4885 |
| US-20180110862-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | TDP1 2667/4885HLCS 1260/4885MEN1 3892/4885 |
| US-20170035893-A1 | ISATOIC ANHYDRIDE DERIVATIVES AND APPLICATIONS THEREOF | AASDHPPT, CA13, CA12 | TDP1 2667/4885HLCS 1260/4885MEN1 3892/4885 |
| US-20110319293-A1 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY | SENP1, STUB1, SENP7 | TDP1 1593/4885HLCS 503/4885MEN1 2755/4885 |
| US-10905665-B2 | Chemical modulators of signaling pathways and therapeutic use | SFRP1, FZD7, WNT1 | TDP1 4810/4885HLCS 2454/4885MEN1 3144/4885 |
| US-20230028321-A1 | NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF | POLRMT, NSUN2, NUDT1 | TDP1 132/4885HLCS 1651/4885MEN1 3223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.