SCHEMBL2755680

SCHEMBL2755680

COP(=O)(O)OCCCCCCN

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LPAR3 Q9UBY5 8/20 0.44
LPAR2 Q9HBW0 7/20 0.44
LPAR1 Q92633 4/20 0.44
ITPR3 Q14573 1/20 0.42
ITPR1 Q14643 1/20 0.42
GABBR2 O75899 2/20 0.39
GABBR1 Q9UBS5 2/20 0.39
CYP1A2 P05177 1/20 0.39
TSHR P16473 1/20 0.39
THPO P40225 1/20 0.39
FDPS P14324 1/20 0.38
LMNA P02545 2/20 0.38
BLM P54132 2/20 0.38
PLA2G2C Q5R387 1/20 0.38
PLA2G2A P14555 2/20 0.37
CYP3A4 P08684 1/20 0.37
NFKB1 P19838 1/20 0.37
PMP22 Q01453 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26079101 1.00 LPAR3 (0.44) LPAR3LPAR2LPAR1ITPR3ITPR1
SCHEMBL19237471 1.00 LPAR3 (0.44) LPAR3LPAR2LPAR1ITPR3ITPR1
SCHEMBL14727906 0.96 LPAR3 (0.41) LPAR3LPAR2LPAR1ITPR3ITPR1
SCHEMBL17052326 0.92 ITPR3 (0.49) LPAR3LPAR2LPAR1ITPR3ITPR1
SCHEMBL23631720 0.87 ITPR3 (0.47) LPAR3LPAR2LPAR1ITPR3ITPR1
SCHEMBL15935828 0.85 LPAR3 (0.48) LPAR3LPAR2LPAR1PLA2G2ACYP3A4
SCHEMBL10178024 0.85 LPAR3 (0.48) LPAR3LPAR2LPAR1PLA2G2ACYP3A4
SCHEMBL23631717 0.85 ITPR3 (0.49) LPAR3LPAR2LPAR1ITPR3ITPR1
SCHEMBL10177948 0.83 LPAR3 (0.45) LPAR3LPAR2LPAR1PLA2G2ACYP3A4
SCHEMBL12583935 0.83

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240026421-A1 METHODS FOR CAPTURING LONG POLYNUCLEOTIDES FOR SEQUENCING SPECIFIC GENOMIC REGIONS GENERATION BIOTECH, LLC (US) 2024-01-25 US disclosed
US-20240026421-A1 METHODS FOR CAPTURING LONG POLYNUCLEOTIDES FOR SEQUENCING SPECIFIC GENOMIC REGIONS GENERATION BIOTECH, LLC (US) 2024-01-25 US disclosed
US-11840688-B2 Compositions and methods for inhibiting gene expression of Hif2alpha Arrowhead Pharmaceuticals, Inc. (US) 2023-12-12 US disclosed
US-11821023-B2 Method for capturing long polynucleotides for sequencing specific gnomic regions GENERATION BIOTECH, LLC (US) 2023-11-21 US disclosed
US-11821023-B2 Method for capturing long polynucleotides for sequencing specific gnomic regions GENERATION BIOTECH, LLC (US) 2023-11-21 US disclosed
US-20230357776-A1 COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSION IONIS PHARMACEUTICALS, INC. (US) 2023-11-09 US disclosed
US-20230348904-A1 SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS BANK OF AMERICA, N.A. 2023-11-02 US disclosed
US-20230338555-A1 CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF IONIS PHARMACEUTICALS, INC. (US) 2023-10-26 US disclosed
US-20230310486-A1 CONJUGATED OLIGONUCLEOTIDE COMPOUNDS, METHODS OF MAKING AND USES THEREOF E-THERAPEUTICS PLC (GB) 2023-10-05 US disclosed
US-20230295628-A1 NUCLEIC ACID COMPLEX NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2023-09-21 US disclosed
US-20100323967-A1 RNA Antagonist Compounds for the Modulation of MCL-1 SANTARIS PHARMA A/S (DK) 2010-12-23 US disclosed
US-20100317714-A1 COMPLEX MOLECULE INTERFERING THE EXPRESSION OF TARGET GENES AND ITS PREPARING METHODS SUZHOU RIBO LIFE SCIENCE CO., LTD (CN) 2010-12-16 US disclosed
US-20100298410-A1 MICROMIRs SANTARIS PHARMA A/S 2010-11-25 US disclosed
US-20100234451-A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR ENZON PHARMACEUTICALS, INC. (US) 2010-09-16 US disclosed
US-20100028873-A1 METHODS AND MEANS FOR NUCLEIC ACID SEQUENCING GENIZON BIOSCIENCES, INC. (CA) 2010-02-04 US disclosed
US-20090298916-A1 Pharmaceutical compositions for treatment of microRNA related diseases SANTARIS PHARMA A/S (DK) 2009-12-03 US disclosed
US-20090203137-A1 COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION SANTARIS PHARMA A/S (DK) 2009-08-13 US disclosed
US-20090192110-A1 RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF PIK3CA EXPRESSION SANTARIS PHARMA A/S 2009-07-30 US disclosed
US-20090181916-A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR SANTARIS PHARMA A/S (DK) 2009-07-16 US disclosed
US-20090143326-A1 MICROMIRs SANTARIS PHARMA A/S (DK) 2009-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143326-A1 MICROMIRs TRDMT1, METTL16, MTNR1A LPAR3 613/4885LPAR2 1163/4885LPAR1 1434/4885
US-20090192110-A1 RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF PIK3CA EXPRESSION PIK3CA, PIK3R4, PIK3R5 LPAR3 543/4885LPAR2 937/4885LPAR1 761/4885
US-20090203137-A1 COMPOUNDS FOR THE MODULATION OF BETA-CATENIN EXPRESSION CTNNB1, CTNNA1, WNT1 LPAR3 350/4885LPAR2 929/4885LPAR1 602/4885
US-20090181916-A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR AR, ESRRB, ESRRA LPAR3 15/4885LPAR2 29/4885LPAR1 19/4885
US-20100234451-A1 LNA ANTAGONISTS TARGETING THE ANDROGEN RECEPTOR AR, ESRRB, LHCGR LPAR3 16/4885LPAR2 31/4885LPAR1 21/4885
US-20230295628-A1 NUCLEIC ACID COMPLEX POLRMT, SNRPE, FABP7 LPAR3 146/4885LPAR2 93/4885LPAR1 145/4885
US-20230338555-A1 CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF DCLRE1B, RNASE1, LNPEP LPAR3 800/4885LPAR2 753/4885LPAR1 810/4885
US-11840688-B2 Compositions and methods for inhibiting gene expression of Hif2alpha EPAS1, HIF1AN, EGLN2 LPAR3 1310/4885LPAR2 538/4885LPAR1 1570/4885
US-20230310486-A1 CONJUGATED OLIGONUCLEOTIDE COMPOUNDS, METHODS OF MAKING AND USES THEREOF DCLRE1B, POLRMT, POLI LPAR3 247/4885LPAR2 777/4885LPAR1 698/4885
US-20090298916-A1 Pharmaceutical compositions for treatment of microRNA related diseases NSUN3, TRDMT1, NSUN2 LPAR3 418/4885LPAR2 576/4885LPAR1 519/4885
US-20100317714-A1 COMPLEX MOLECULE INTERFERING THE EXPRESSION OF TARGET GENES AND ITS PREPARING METHODS DCLRE1B, RNASE1, AGO2 LPAR3 1764/4885LPAR2 1784/4885LPAR1 1843/4885
US-20100323967-A1 RNA Antagonist Compounds for the Modulation of MCL-1 MCL1, NSUN2, MCTS1 LPAR3 560/4885LPAR2 815/4885LPAR1 450/4885
US-20100298410-A1 MICROMIRs TRDMT1, METTL16, MTNR1A LPAR3 613/4885LPAR2 1163/4885LPAR1 1434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.