Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061999 | 0.84 | RAB9A (0.41) | CYP2A6KDM4EL3MBTL1BRD4CYP1A2 | |
| SCHEMBL10465159 | 0.81 | L3MBTL1 (0.50) | KDM4EL3MBTL1CYP1A2HPGDCYP3A4 | |
| SCHEMBL10727406 | 0.81 | CYP2A6 (0.56) | CYP2A6ACACB | |
| SCHEMBL6348729 | 0.80 | LOXL2 (0.52) | KDM4EBRD4CYP1A2CYP2D6HPGD | |
| SCHEMBL1585201 | 0.80 | ALOX5AP (0.37) | CYP2A6BRD4CYP3A4ARRAB9A | |
| SCHEMBL24146512 | 0.79 | GAA (0.38) | KDM4EL3MBTL1BRD4ARCHEK1 | |
| SCHEMBL2643631 | 0.79 | BRD4 (0.36) | BRD4ARRAB9ACHEK1EGLN2 | |
| SCHEMBL20448721 | 0.79 | KDM4E (0.42) | CYP2A6KDM4EL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL453184 | 0.79 | BRD4 (0.39) | BRD4ARCHEK1EGLN2NAMPT | |
| SCHEMBL507109 | 0.79 | AR (0.41) | BRD4CYP1A2ARCHEK1EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050370-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | 1CBIO, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| US-20230373972-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-11-23 | — | — | US | disclosed |
| WO-2023128282-A1 | BIFUNCTIONAL LINKER COMPRISING METAALLYLSILANE AND METHOD FOR PREPARING SAME | 한양대학교 에리카산학협력단 | 2023-07-06 | — | — | WO | disclosed |
| CN-110325527-B | Sulfonamides as inhibitors of extracellular citrate uptake | 勃林格殷格翰国际有限公司 | 2022-08-09 | — | — | CN | disclosed |
| US-11254686-B1 | Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor | CORVUS PHARMACEUTICALS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| US-11034671-B2 | Apoptosis signal-regulating kinase inhibitors and uses thereof | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20200392138-A1 | PESTICIDALLY ACTIVE MESOIONIC HETEROCYCLIC COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2020-12-17 | — | — | US | disclosed |
| US-10865215-B2 | Benzodiazepine derivatives as RSV inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2020-12-15 | — | — | US | disclosed |
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| EP-3551618-B1 | SULFONAMIDES AS INHIBITORS OF THE UPTAKE OF EXTRACELLULAR CITRATE | BOEHRINGER INGELHEIM INT (DE) | 2020-09-16 | — | — | EP | disclosed |
| US-7273853-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2007-09-25 | — | — | US | disclosed |
| EP-1697370-B1 | AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2007-04-25 | — | — | EP | disclosed |
| US-7189704-B2 | 6-11 bicyclic ketolide derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189728-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING, BV (NL) | 2007-03-13 | — | — | US | disclosed |
| JP-2000226370-A | PRODUCTION OF 2-ACYLPYRIDINE DERIVATIVE | KURARAY CO LTD | 2000-08-15 | — | — | JP | disclosed |
| US-4923993-A | Process for the preparation of 2-pyridinecarboxylic acid derivatives and 1-amino-1,4-dihydropyridine-2-carboxylic acid derivatives | CIBA-GEIGY CORPORATION (US) | 1990-05-08 | — | — | US | disclosed |
| EP-0221023-A2 | Process for the preparation of pyridine-2-carboxylic-acid derivatives and 1-amino-1,4-dihydropyridine-2-carboxylic-acid derivatives | CIBA-GEIGY AG (CH) | 1987-05-06 | — | — | EP | disclosed |
| US-4192880-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | KANEBO, LTD. (JP) | 1980-03-11 | — | — | US | disclosed |
| US-4188486-A | 2-Substituted benzimidazole compounds | KANEBO, LTD. (JP) | 1980-02-12 | — | — | US | disclosed |
| US-3959297-A | AMMOXIDATION OF 2-METHYL-5-ETHYLPYRIDINE; METAL OXIDE CATALYST | SHOWA DENKO KABUSHIKI KAISHA (JA) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10865215-B2 | Benzodiazepine derivatives as RSV inhibitors | GABRA5, GABRA1, GABBR2 | CYP2A6 91/4885KDM4E 1198/4885L3MBTL1 4773/4885 |
| US-11254686-B1 | Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor | ADORA2A, ADORA2B, ADORA3 | CYP2A6 726/4885KDM4E 4408/4885L3MBTL1 4512/4885 |
| US-11034671-B2 | Apoptosis signal-regulating kinase inhibitors and uses thereof | DAPK1, ATF1, BAD | CYP2A6 4487/4885KDM4E 3408/4885L3MBTL1 677/4885 |
| US-20200392138-A1 | PESTICIDALLY ACTIVE MESOIONIC HETEROCYCLIC COMPOUNDS | DDT, ACHE, MNS1 | CYP2A6 734/4885KDM4E 4007/4885L3MBTL1 2139/4885 |
| US-10793522-B2 | Sulfonamides as inhibitors of the uptake of extracellular citrate | CS, GLS, GLS2 | CYP2A6 1153/4885KDM4E 2569/4885L3MBTL1 4480/4885 |
| US-20230373972-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | F7, F11, HABP2 | CYP2A6 701/4885KDM4E 1788/4885L3MBTL1 4402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.