Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 18/20 | 0.50 |
| ▸ | CA1 known ✓ | P00915 | 15/20 | 0.50 |
| ▸ | CA12 known ✓ | O43570 | 13/20 | 0.50 |
| ▸ | CA4 known ✓ | P22748 | 7/20 | 0.50 |
| ▸ | CA9 | Q16790 | 14/20 | 0.50 |
| ▸ | CA5A | P35218 | 9/20 | 0.50 |
| ▸ | CA7 | P43166 | 8/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.50 |
| ▸ | CA6 | P23280 | 6/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.50 |
| ▸ | CA3 | P07451 | 3/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19880 | 0.95 | CA2 (0.55) | CA2CA1CA9CA12CA5A | |
| Water SCHEMBL28835117 | 0.95 | CA2 (0.55) | CA2CA1CA9CA12CA5A | |
| Benzenesulfonamide SCHEMBL27357661 | 0.86 | CA2 (0.73) | CA2CA1CA9CA12CA5A | |
| SCHEMBL27491694 | 0.81 | CA2 (0.73) | CA2CA1CA9CA12CA5A | |
| SCHEMBL28554532 | 0.74 | SOS1 (0.56) | CA2CA1CA9CA12CA5A | |
| SCHEMBL202948 | 0.74 | CA2 (0.81) | CA2CA1CA9CA12CA5A | |
| SCHEMBL818508 | 0.73 | HTR6 (0.50) | TSHRALDH1A1 | |
| SCHEMBL28709583 | 0.72 | TDP1 (0.43) | TDP1 | |
| Benzenesulfonamide SCHEMBL1009443 | 0.70 | CA2 (0.94) | CA2CA1CA9CA12CA5A | |
| SCHEMBL20194 | 0.69 | ENPP2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108383874-A | The method for being used to prepare acylphosphanes | 瑞士联邦苏黎世技术大学 | 2018-08-10 | — | — | CN | disclosed |
| CN-104703995-B | Process for preparing acylphosphanes | 瑞士联邦苏黎世技术大学 | 2018-04-20 | — | — | CN | disclosed |
| CN-104703995-A | Process for preparing acylphosphanes | EIDGENOESS TECH HOCHSCHULE | 2015-06-10 | — | — | CN | disclosed |