SCHEMBL2807525

SCHEMBL2807525

N#C/C(=C/C=C(c1ccccc1)c1ccccc1)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.44
ALDH1A1 P00352 6/20 0.44
KDM4E B2RXH2 5/20 0.44
PKM P14618 3/20 0.44
ATM Q13315 1/20 0.44
LMNA P02545 1/20 0.44
MCL1 Q07820 2/20 0.43
EGFR P00533 2/20 0.43
HPGD P15428 2/20 0.43
CISD1 Q9NZ45 1/20 0.43
SLC16A3 O15427 1/20 0.43
CYP3A4 P08684 1/20 0.43
SLC16A1 P53985 1/20 0.43
GPR35 Q9HC97 1/20 0.43
ERBB2 P04626 1/20 0.42
MAPT P10636 2/20 0.41
POLB P06746 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4857575 1.00 KMT2A (0.44) KMT2AALDH1A1KDM4EPKMATM
SCHEMBL2807530 1.00 KMT2A (0.44) KMT2AALDH1A1KDM4EPKMATM
SCHEMBL11941275 0.82 MAPT (0.49) KMT2AALDH1A1HPGDSLC16A3SLC16A1
SCHEMBL1576724 0.82 POLB (0.46) KMT2AALDH1A1KDM4EPKMATM
SCHEMBL1576722 0.82 POLB (0.46) KMT2AALDH1A1KDM4EPKMATM
SCHEMBL14163400 0.80 DNM1 (0.46) KMT2AALDH1A1KDM4EPKMATM
SCHEMBL17466006 0.78 MAPT (0.52) KMT2AALDH1A1KDM4EATMLMNA
SCHEMBL11941574 0.77 MAPT (0.48) KMT2AALDH1A1HPGDSLC16A3SLC16A1
SCHEMBL11435558 0.76 NFE2L2 (0.53) KMT2AALDH1A1KDM4EPKMATM
SCHEMBL11435556 0.76 NFE2L2 (0.53) KMT2AALDH1A1KDM4EPKMATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2683351-B1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME OREAL (FR) 2019-10-16 EP disclosed
EP-2266531-B1 Cosmetic composition comprising a superabsorbent polymer and an organic UV filter L'ORÉAL (FR) 2017-06-14 EP disclosed
EP-2538914-B1 COSMETIC COMPOSITION COMPRISING A SUPERABSORBENT POLYMER AND AT LEAST A GEMINI SURFACTANT ORÉAL L (FR) 2016-06-15 EP disclosed
EP-2482793-B1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT ORÉAL L (FR) 2015-04-22 EP disclosed
US-8716311-B2 Use of piperidine ester derivative as solvent in cosmetic compositions; cosmetic compositions comprising it L'OREAL (FR) 2014-05-06 US disclosed
US-20140056832-A1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'OREAL (FR) 2014-02-27 US disclosed
EP-2683351-A2 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'Oréal (FR) 2014-01-15 EP disclosed
EP-2538914-A1 COMPOSITION COMPRISING A SUPERABSORBENT POLYMER AND A GEMINI SURFACTANT L'Oréal (FR) 2013-01-02 EP disclosed
US-20120282197-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2012-11-08 US disclosed
US-20120269746-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'OREAL (FR) 2012-10-25 US disclosed
WO-2012119861-A2 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME L'OREAL (FR) 2012-09-13 WO disclosed
EP-2482793-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'Oréal (FR) 2012-08-08 EP disclosed
EP-2482791-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT L'Oréal (FR) 2012-08-08 EP disclosed
US-20100330018-A1 COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT L'OREAL (FR) 2010-12-30 US disclosed
EP-2266531-A1 Cosmetic composition comprising a superabsorbent polymer and an organic UV filter L'Oréal (FR) 2010-12-29 EP disclosed
US-20100143276-A1 Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions L'OREAL (FR) 2010-06-10 US disclosed
EP-2193783-A1 Use of an ester derived from 4-carboxy-2-pyrrolidinone as a solvent in cosmetic compositions; cosmetic compositions containing same L'Oreal (FR) 2010-06-09 EP disclosed
EP-1535925-B1 4,4-Diarylbutadiene functionalized methyltrialkylsilanes and cosmetic or photoprotective dermatological compositions containing them OREAL (FR) 2009-05-27 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140056832-A1 USE OF A 2-METHYLSUCCINIC ACID DIESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS CONTAINING THE SAME DIMT1, MAT2A, SCD KMT2A 326/4885ALDH1A1 380/4885KDM4E 591/4885
US-20120282197-A1 USE OF PIPERIDINE ESTER DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT PLD1, PLD2, FFAR1 KMT2A 2887/4885ALDH1A1 49/4885KDM4E 2600/4885
US-20100330018-A1 COMPOSITION CONTAINING A SUPERABSORBENT POLYMER AND AN ORGANIC UV SCREENING AGENT KRT18, FABP2, FABP4 KMT2A 2861/4885ALDH1A1 699/4885KDM4E 3344/4885
US-20120269746-A1 USE OF CAPROLACTAM DERIVATIVE AS SOLVENT IN COSMETIC COMPOSITIONS; COSMETIC COMPOSITIONS COMPRISING IT DEGS1, CAPN1, PPT1 KMT2A 4112/4885ALDH1A1 237/4885KDM4E 3150/4885
US-20100143276-A1 Ester solvents derived from 4-carboxy-2-pyrrolidinone formulated into UV-screening cosmetic compositions FASN, ALOX12, PAH KMT2A 2116/4885ALDH1A1 201/4885KDM4E 148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.