Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31041181 | 0.85 | TSHR (0.37) | ALDH1A1HTTMAPTSMN1; SMN2TDP1 | |
| SCHEMBL24133302 | 0.81 | LMNA (0.40) | ALDH1A1MAPTSMN1; SMN2TDP1KDM4E | |
| SCHEMBL28009643 | 0.80 | TSHR (0.41) | ALDH1A1SMN1; SMN2TDP1KDM4ETSHR | |
| SCHEMBL3917312 | 0.80 | LPAR1 (0.49) | ALDH1A1HTTMAPTSMN1; SMN2TDP1 | |
| SCHEMBL17034855 | 0.79 | GAA (0.40) | ALDH1A1HTTMAPTSMN1; SMN2TSHR | |
| SCHEMBL27645331 | 0.79 | GAA (0.45) | ALDH1A1HTTMAPTTDP1KDM4E | |
| SCHEMBL29970124 | 0.79 | GABRA1 (0.37) | ALDH1A1HTTMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL19617651 | 0.79 | GABRA1 (0.37) | ALDH1A1HTTMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL2370519 | 0.78 | MAPK1 (0.54) | ALDH1A1HTTMAPTSMN1; SMN2TDP1 | |
| SCHEMBL14125147 | 0.78 | PTGDR2 (0.42) | ALDH1A1HTTMAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339993-A1 | PREPARATION METHOD OF A CYCLIC PHOSPHONATE COMPOUND | GANNEX PHARMA CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| US-11725019-B2 | Preparation method of a cyclic phosphonate compound | GANNEX PHARMA CO LTD. (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20220162161-A1 | Novel compounds and their uses as thyroid hormone receptor agonists | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2022-05-26 | — | — | US | disclosed |
| EP-1689383-B1 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-2428516-A1 | Novel phosphorus-containing thyromimetics | Metabasis Therapeutics, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| US-7829552-B2 | Phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20100081634-A1 | Novel Phosphorus-Containing Thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| US-20090118236-A1 | Novel Phosphorus-Containing Thyromimetics | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2009-05-07 | — | — | US | disclosed |
| US-7514419-B2 | Phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. (US) | 2009-04-07 | — | — | US | disclosed |
| US-20090028925-A1 | Novel Phosphinic Acid-Containing Thyromimetics | METABASIS THERAPEUTICS, INC. | 2009-01-29 | — | — | US | disclosed |
| CN-101189248-A | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2008-05-28 | — | — | CN | disclosed |
| CN-101180097-A | Novel phosphinic acid-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2008-05-14 | — | — | CN | disclosed |
| CN-1882327-A | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS INC (US) | 2006-12-20 | — | — | CN | disclosed |
| US-20060046980-A1 | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220162161-A1 | Novel compounds and their uses as thyroid hormone receptor agonists | THRA, THRB, TSHR | ALDH1A1 2389/4885HTT 304/4885MAPT 270/4885 |
| US-11725019-B2 | Preparation method of a cyclic phosphonate compound | PHOSPHO1, PPIP5K2, PNKP | ALDH1A1 3451/4885HTT 4674/4885MAPT 3701/4885 |
| US-20100081634-A1 | Novel Phosphorus-Containing Thyromimetics | PYGL, THRA, THOP1 | ALDH1A1 4227/4885HTT 2134/4885MAPT 3512/4885 |
| US-20060046980-A1 | Novel phosphorus-containing thyromimetics | PYGL, THRA, THOP1 | ALDH1A1 4227/4885HTT 2134/4885MAPT 3512/4885 |
| US-20090118236-A1 | Novel Phosphorus-Containing Thyromimetics | THRA, PYGL, THRB | ALDH1A1 4038/4885HTT 1991/4885MAPT 3885/4885 |
| US-20230339993-A1 | PREPARATION METHOD OF A CYCLIC PHOSPHONATE COMPOUND | PHOSPHO1, PPIP5K2, PNKP | ALDH1A1 3451/4885HTT 4674/4885MAPT 3701/4885 |
| US-20090028925-A1 | Novel Phosphinic Acid-Containing Thyromimetics | PYGL, PHOSPHO1, LIPE | ALDH1A1 4147/4885HTT 1592/4885MAPT 3105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.