SCHEMBL2850882

SCHEMBL2850882

O=C(Nc1nccc2ccccc12)Oc1cnn(-c2cccc(Cl)n2)c1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 19/20 0.44
PHGDH O43175 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2856635 0.90 MALT1 (0.42) MALT1PHGDH
SCHEMBL2858340 0.86 MALT1 (0.42) MALT1PHGDH
SCHEMBL2855599 0.85 MALT1 (0.57) MALT1
SCHEMBL2853326 0.81 MALT1 (0.39) MALT1PHGDH
SCHEMBL2852553 0.81 MALT1 (0.40) MALT1
SCHEMBL2852401 0.79 L3MBTL1 (0.39)
SCHEMBL2852387 0.79 P2RX7 (0.37) MALT1
SCHEMBL2854492 0.77 MAPT (0.42) MALT1
SCHEMBL2857955 0.77 NPY5R (0.42) MALT1
SCHEMBL2856129 0.77 DRD2 (0.35) MALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 EP claimed