Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.37 |
| ▸ | F10 known ✓ | P00742 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.33 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.33 |
| ▸ | NAT1 | P18440 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31149191 | 0.91 | PTGS2 (0.43) | PTPN1PTGS2PKLRCASP1TTR | |
| Styrene SCHEMBL30678383 | 0.88 | ALDH1A1 (0.40) | PTPN1PTGS2PKLRCASP1TTR | |
| (Z)-1,2-Diphenylethene SCHEMBL29093047 | 0.87 | PTPN1 (0.43) | PTPN1PTPN6PTGS2PKLRTRPV1 | |
| SCHEMBL29991128 | 0.86 | PTPN1 (0.40) | PTPN1PTPN6PTGS2PKLRTRPV1 | |
| SCHEMBL38569 | 0.83 | RAD51 (0.36) | PTPN1PKLRTRPV1NFE2L2RAD51 | |
| SCHEMBL3045651 | 0.81 | MAOB (0.45) | PTPN1PTPN6PTGS2PKLRTRPV1 | |
| SCHEMBL3936742 | 0.81 | NFE2L2 (0.41) | NFE2L2RAD51 | |
| (Z)-1,2-Diphenylethene SCHEMBL28265888 | 0.78 | PTPN1 (0.44) | PTPN1PTPN6PTGS2TRPV1NFE2L2 | |
| SCHEMBL3045652 | 0.78 | PELI1 (0.39) | PTPN1PTPN6PTGS2TRPV1NFE2L2 | |
| SCHEMBL30835513 | 0.77 | PTPN1 (0.40) | PTPN1PTPN6PTGS2PKLRNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110791010-B | Modification process of high-performance antimony bromide type flame-retardant master batch | 广西华锑科技有限公司 | 2022-06-14 | — | — | CN | claimed |
| CN-120119485-A | Archival paper and manufacturing method thereof | 亚太森博（山东）浆纸有限公司 | 2025-06-10 | — | — | CN | disclosed |
| CN-111251500-B | Foaming polymer particles with skin dilatancy and preparation method thereof | 厦门天策材料科技有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-109666121-B | Hybrid dynamic cross-linked polymer and application thereof | 厦门逍扬运动科技有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-108342049-B | Physical split-phase dynamic polymer and application thereof | 厦门天策材料科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-109666163-B | Hybrid crosslinked dynamic polymer and application thereof | 厦门逍扬运动科技有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-109206570-B | Flexible physical split-phase supermolecular dynamic polymer and application thereof | 厦门天策材料科技有限公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-115522405-A | Thermal sublimation transfer printing paper coating and preparation method and application thereof | 广东冠豪高新技术股份有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-110791010-B | Modification process of high-performance antimony bromide type flame-retardant master batch | 广西华锑科技有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-113710753-A | Washable heat and plasma resistant coatings for laser interactive applications | 约翰·克莱昂·摩尔 | 2021-11-26 | — | — | CN | disclosed |