Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Orange G. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.68 |
| ▸ | SUMO2 | P61956 | 2/20 | 0.55 |
| ▸ | SUMO1 | P63165 | 2/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.55 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orange G SCHEMBL29369740 | 0.81 | APP (1.00) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL81967 | 0.81 | APP (1.00) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL3873344 | 0.81 | APP (1.00) | APPSUMO2SUMO1SENP7SENP2 | |
| SCHEMBL185277 | 0.80 | APP (0.98) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL3020776 | 0.78 | APP (0.70) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL29388415 | 0.78 | APP (0.70) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL17279088 | 0.78 | APP (0.70) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL3020774 | 0.78 | APP (0.70) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL31621938 | 0.78 | APP (0.70) | APPSUMO2SUMO1SENP7SENP2 | |
| Orange G SCHEMBL3873347 | 0.78 | APP (0.70) | APPSUMO2SUMO1SENP7SENP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106770251-A | A kind of urinalysis test paper and preparation method thereof | 天津果实科技有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-104458386-B | Staining method for thrombus compositions and application of staining method | 广州医科大学附属第医院 | 2017-04-26 | — | — | CN | claimed |
| CN-105188934-B | Droplet assembly for 3D printing | 牛津大学创新有限公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-105709701-B | A kind of graphene of load nano particle/mycelia hydrogel and its preparation method and application | 中南大学 | 2018-10-16 | — | — | CN | disclosed |
| CN-108404942-A | A kind of fluorine richness Fe3O4Magnetic Nano material and its preparation method and application | 武汉工程大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-108395002-A | Degradation of Azo Dyes Decolourization Bacteria and its application | 广州中国科学院先进技术研究所 | 2018-08-14 | — | — | CN | disclosed |
| CN-108195653-A | One kind redyes staining kit and preparation and application | 南京福怡科技发展股份有限公司 | 2018-06-22 | — | — | CN | disclosed |
| CN-107473207-A | A kind of preparation method of graphene quantum dot | 中国科学技术大学 | 2017-12-15 | — | — | CN | disclosed |
| CN-105348462-B | A kind of organic mesoporous polymer of triazine radical and its preparation method and application | 武汉工程大学 | 2017-12-12 | — | — | CN | disclosed |
| CN-104155210-B | Optical imagery based on viscoelastic focusing | 彼克斯赛尔医疗科技有限公司 | 2017-08-22 | — | — | CN | disclosed |
| CN-107055740-A | A kind of method that hydroquinones promotes ferriferous oxide catalyzing hydrogen peroxide degraded orange G waste water | 河海大学 | 2017-08-18 | — | — | CN | disclosed |
| CN-101457119-B | Coating composition | KANSAI PAINT CO LTD | 2013-12-18 | — | — | CN | disclosed |
| CN-101896287-B | Method of forming multilayered coating film, multilayered coating film, and coated article | KANSAI PAINT CO LTD | 2013-06-19 | — | — | CN | disclosed |
| CN-103111272-A | Preparation and application of modified polyaniline-palygorskite composite adsorbent | UNIV NORTHWEST NORMAL | 2013-05-22 | — | — | CN | disclosed |
| CN-103055872-A | Calcined anionic clay visible-light catalyst and preparation method and purposes thereof | UNIV SOUTH CHINA TECH | 2013-04-24 | — | — | CN | disclosed |
| CN-102532943-A | Preparation method for reverse phase microemulsion of dye solution | UNIV SOUTHWEST | 2012-07-04 | — | — | CN | disclosed |
| CN-102433734-A | Preparation method of composite nanofiber felt containing iron-nickel bimetallic nanoparticles | UNIV DONGHUA | 2012-05-02 | — | — | CN | disclosed |
| CN-101993531-A | Vinyl modified polyester polyatomic alcohol, two-part curable paint composition and condensate | MUSASHI TORYO KK | 2011-03-30 | — | — | CN | disclosed |
| CN-101896287-A | Method of forming multilayered coating film, multilayered coating film, and coated article | KANSAI PAINT CO LTD | 2010-11-24 | — | — | CN | disclosed |
| CN-101457119-A | Coating composition | KANSAI PAINT CO LTD (JP) | 2009-06-17 | — | — | CN | disclosed |