Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Orange G. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 3/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | DUSP5 | Q16690 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.46 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orange G SCHEMBL29369740 | 1.00 | APP (1.00) | APPTHRBMAPK1ALDH1A1TDP1 | |
| Orange G SCHEMBL81967 | 1.00 | APP (1.00) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL185277 | 0.99 | APP (0.98) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL93701 | 0.84 | APP (0.72) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL93700 | 0.84 | APP (0.72) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL29353967 | 0.84 | APP (0.72) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL10621059 | 0.83 | MAPK1 (0.73) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL1638375 | 0.83 | MAPK1 (0.73) | APPTHRBMAPK1ALDH1A1TDP1 | |
| SCHEMBL29421649 | 0.83 | MAPK1 (0.73) | APPTHRBMAPK1ALDH1A1TDP1 | |
| Orange G SCHEMBL17279088 | 0.82 | APP (0.70) | APPTHRBMAPK1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10365223-B2 | Analytical method using surface enhanced Raman spectroscopy and composition for the method | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2019-07-30 | — | — | US | disclosed |
| EP-3207360-B1 | ANALYTICAL METHOD USING SURFACE ENHANCED RAMAN SPECTROSCOPY | JOHNSON MATTHEY PLC (GB) | 2018-12-12 | — | — | EP | disclosed |
| US-20170307531-A1 | ANALYTICAL METHOD USING SURFACE ENHANCED RAMAN SPECTROSCOPY AND COMPOSITION FOR THE METHOD | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2017-10-26 | — | — | US | disclosed |
| EP-3207360-A1 | ANALYTICAL METHOD USING SURFACE ENHANCED RAMAN SPECTROSCOPY AND COMPOSITION FOR THE METHOD | Johnson Matthey Public Limited Company (GB) | 2017-08-23 | — | — | EP | disclosed |
| WO-2016059429-A1 | ANALYTICAL METHOD USING SURFACE ENHANCED RAMAN SPECTROSCOPY AND COMPOSITION FOR THE METHOD | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2016-04-21 | — | — | WO | disclosed |
| US-9051198-B2 | Nitrogen doped A2Nb4O11, process for preparation thereof, and method for degradation of organic pollutants | CITY UNIVERSITY OF HONG KONG (CN) | 2015-06-09 | — | — | US | disclosed |
| EP-2092385-B1 | MICROSCOPE ILLUMINATION SOURCE COMPRISING LIGHT EMITTING DIODES FOR STAINED BIOLOGICAL SAMPLES | CYTYC CORP (US) | 2013-08-14 | — | — | EP | disclosed |
| US-20120205321-A1 | NITROGEN DOPED A2NB4O11, PROCESS FOR PREPARATION THEREOF, AND METHOD FOR DEGRADATION OF ORGANIC POLLUTANTS | CITY UNIVERSITY OF HONG KONG (CN) | 2012-08-16 | — | — | US | disclosed |
| EP-1523339-B2 | COMPOSITION FOR CONTROLLED RELEASE OF PERFUMES AND FLAVOURS | FIRMENICH & CIE (CH) | 2011-12-14 | — | — | EP | disclosed |
| EP-2092385-A1 | ILLUMINATION SOURCE COMPRISING LIGHT EMITTING DIODES FOR STAINED BIOLOGICAL SAMPLES | Cytyc Corporation (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008073728-A1 | ILLUMINATION SOURCE COMPRISING LIGHT EMITTING DIODES FOR STAINED BIOLOGICAL SAMPLES | CYTYC CORPORATION (US) | 2008-06-19 | — | — | WO | disclosed |
| US-20080144169-A1 | ILLUMINATION SOURCE FOR STAINED BIOLOGICAL SAMPLES | CYTYC CORPORATION (US) | 2008-06-19 | — | — | US | disclosed |
| US-7261857-B2 | Colorimetric artificial nose having an array of dyes and method for artificial olfaction | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-08-28 | — | — | US | disclosed |
| EP-1523339-B1 | COMPOSITION FOR CONTROLLED RELEASE OF PERFUMES AND FLAVOURS | FIRMENICH & CIE (CH) | 2006-12-27 | — | — | EP | disclosed |
| US-20030166298-A1 | Colorimetric artificial nose having an array of dyes and method for artificial olfaction | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2003-09-04 | — | — | US | disclosed |
| US-20030143112-A1 | Colorimetric artificial nose having an array of dyes and method for artificial olfaction | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2003-07-31 | — | — | US | disclosed |
| US-4784959-A | Method of detecting hydrocarbon fuel leaks | LOCKHEED CORPORATION (US) | 1988-11-15 | — | — | US | disclosed |
| US-4756854-A | Method and apparatus for detecting hydrocarbon fuel leaks | LOCKHEED CORPORATION (US) | 1988-07-12 | — | — | US | disclosed |
| US-4745797-A | Method and apparatus for detecting hydrocarbon fuel leaks | LOCKHEED CORPORATION (US) | 1988-05-24 | — | — | US | disclosed |
| US-4615828-A | Method and apparatus for detecting hydrocarbon fuel leaks | LOCKHEED CORPORATION (US) | 1986-10-07 | — | — | US | disclosed |