Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624195 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL5879040 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL5878864 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL10816802 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL6363268 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL28744317 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL5878849 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL8028607 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL7782170 | 0.98 | CA2 (0.65) | CA2MAPK1BLMCHRM1AKR1A1 | |
| SCHEMBL1509190 | 0.95 | CA2 (0.68) | CA2MAPK1BLMCHRM1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12053537-B2 | Reduction of stinging sensation on skin | SYMRISE AG (DE) | 2024-08-06 | — | — | US | disclosed |
| US-20230101832-A1 | STABLE, LIQUID EMULSIFIERS ON THE BASIS OF CITRATE ESTERS AND THEIR USE | SYMRISE AG (DE) | 2023-03-30 | — | — | US | disclosed |
| CN-112739804-A | Fabric softener composition | 塔明克公司 | 2021-04-30 | — | — | CN | disclosed |
| EP-3373895-A1 | REDUCTION OF STINGING SENSATION ON SKIN | Symrise AG (DE) | 2018-09-19 | — | — | EP | disclosed |
| US-20180185301-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL DERIVATIVES | SYMRISE AG (DE) | 2018-07-05 | — | — | US | disclosed |
| US-9820923-B2 | Succinate derivatives | SYMRISE AG (DE) | 2017-11-21 | — | — | US | disclosed |
| WO-2017080625-A1 | REDUCTION OF STINGING SENSATION ON SKIN | SYMRISE AG (DE) | 2017-05-18 | — | — | WO | disclosed |
| US-9585388-B2 | Synergistically acting ternary antimicrobial mixtures | SYMRISE AG (DE) | 2017-03-07 | — | — | US | disclosed |
| US-20160128923-A1 | New Succinate Derivatives | SYMRISE AG (DE) | 2016-05-12 | — | — | US | disclosed |
| US-20160008297-A1 | COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) | B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) | 2016-01-14 | — | — | US | disclosed |
| US-9125936-B2 | Ginger extract for the protection of stem cells | SYMRISE AG (DE) | 2015-09-08 | — | — | US | disclosed |
| US-9060943-B2 | Compositions comprising trans-tert-butyl cyclohexanol as skin irritation-reducing agent | SYMRISE AG (DE) | 2015-06-23 | — | — | US | disclosed |
| US-8951507-B2 | Formulation with irritation reducing action comprising bisabolol and [6]-paradol | SYMRISE AG (DE) | 2015-02-10 | — | — | US | disclosed |
| US-20140242020-A1 | Ginger Extract for the Protection of Stem Cells | SYMRISE AG (DE) | 2014-08-28 | — | — | US | disclosed |
| US-20130136709-A1 | SYNERGISTICALLY ACTING TERNARY ANTIMICROBIAL MIXTURES | SYMRISE AG (DE) | 2013-05-30 | — | — | US | disclosed |
| US-8354128-B2 | Blackberry leaf extract as an active ingredient against skin irritations and inflammations | SYMRISE AG (DE) | 2013-01-15 | — | — | US | disclosed |
| US-20120258058-A1 | FORMULATION WITH IRRITATION REDUCING ACTION COMPRISING BISABOLOL AND [6]-PARADOL | SYMRISE AG (DE) | 2012-10-11 | — | — | US | disclosed |
| US-20120121737-A1 | COMPOSITIONS COMPRISING TRANS-TERT-BUTYL CYCLOHEXANOL AS SKIN IRRITATION-REDUCING AGENT | SYMRISE AG (DE) | 2012-05-17 | — | — | US | disclosed |
| US-20100286102-A1 | Formulations comprising ceramides and/or pseudoceramides and (alpha-)bisabolol for combating skin damage | SYMRISE GMBH & CO. KG (DE) | 2010-11-11 | — | — | US | disclosed |
| US-20100239695-A1 | BLACKBERRY LEAF EXTRACT AS AN ACTIVE INGREDIENT AGAINST SKIN IRRITATIONS AND INFLAMMATIONS | SYMRISE GMBH & CO. KG (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286102-A1 | Formulations comprising ceramides and/or pseudoceramides and (alpha-)bisabolol for combating skin damage | CERT1, CERS2, SGMS1 | CA2 1247/4885MAPK1 3348/4885BLM 4337/4885 |
| US-12053537-B2 | Reduction of stinging sensation on skin | STING1, TYR, CUTA | CA2 775/4885MAPK1 3689/4885BLM 2507/4885 |
| US-20120258058-A1 | FORMULATION WITH IRRITATION REDUCING ACTION COMPRISING BISABOLOL AND [6]-PARADOL | FHIT, DAGLA, TRPV1 | CA2 2807/4885MAPK1 3384/4885BLM 1673/4885 |
| US-20160008297-A1 | COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) | TRPV2, TRPV1, TRPM2 | CA2 150/4885MAPK1 1528/4885BLM 3874/4885 |
| US-20140242020-A1 | Ginger Extract for the Protection of Stem Cells | HSD11B1, HSD3B1, EBP | CA2 4746/4885MAPK1 2198/4885BLM 1972/4885 |
| US-20120121737-A1 | COMPOSITIONS COMPRISING TRANS-TERT-BUTYL CYCLOHEXANOL AS SKIN IRRITATION-REDUCING AGENT | TERT, CUTA, TRPA1 | CA2 4440/4885MAPK1 2452/4885BLM 1231/4885 |
| US-20180185301-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING POLYALKYLENE GLYCOL DERIVATIVES | PARG, PARN, TRPV1 | CA2 557/4885MAPK1 3682/4885BLM 2130/4885 |
| US-20160128923-A1 | New Succinate Derivatives | SUCNR1, SDHB, SDHA | CA2 1024/4885MAPK1 3584/4885BLM 4184/4885 |
| US-20230101832-A1 | STABLE, LIQUID EMULSIFIERS ON THE BASIS OF CITRATE ESTERS AND THEIR USE | ACADM, ACACB, CS | CA2 196/4885MAPK1 3909/4885BLM 3048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.