Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812723 | 0.89 | GABRA1 (0.52) | MAPK1NLRP3LMNAGABRA1GABRG2 | |
| SCHEMBL3352406 | 0.86 | RAPGEF4 (0.58) | — | |
| SCHEMBL12076480 | 0.83 | GABRA1 (0.43) | MAPK1NLRP3LMNAGABRA1GABRG2 | |
| SCHEMBL5082721 | 0.83 | MAPK1 (0.47) | MAPK1NLRP3LMNAGABRA1GABRG2 | |
| SCHEMBL4804825 | 0.82 | CXCL8 (0.44) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2866658 | 0.81 | MAPK1 (0.46) | MAPK1NLRP3LMNAGABRA1GABRG2 | |
| SCHEMBL2927525 | 0.81 | ALDH1A1 (0.54) | LMNACA1CA2CYP1A2CYP3A4 | |
| SCHEMBL114632 | 0.79 | MAPK1 (0.49) | MAPK1NLRP3LMNAGABRA1GABRG2 | |
| SCHEMBL5839727 | 0.79 | MAPK1 (0.49) | MAPK1NLRP3LMNAGABRA1GABRG2 | |
| SCHEMBL29464080 | 0.79 | MAPK1 (0.49) | MAPK1NLRP3LMNAGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442800-B2 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-10-28 | — | — | US | claimed |
| CN-101184711-A | Nucleophilic heterocyclic carbene derivatives of pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-05-21 | — | — | CN | claimed |
| EP-1885669-A1 | NUCLEOPHILIC HETEROCYCLIC CARBENE DERIVATIVES OF PD(ACAC)2 FOR CROSS-COUPLING REACTIONS | Promerus LLC (US) | 2008-02-13 | — | — | EP | claimed |
| US-20060287544-A1 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2006-12-21 | — | — | US | claimed |
| WO-2006128097-A1 | NUCLEOPHILIC HETEROCYCLIC CARBENE DERIVATIVES OF PD(ACAC)2 FOR CROSS-COUPLING REACTIONS | PROMERUS LLC (US) | 2006-11-30 | — | — | WO | claimed |
| WO-2022078306-A1 | LARGE STERIC HINDERANCE PALLADIUM-NITROGEN-HETEROCYCLIC CARBENE COMPLEX, PREPARATION METHOD FOR SAME, APPLICATIONS OF SAME, AND SYNTHESIS METHOD FOR SONIDEGIB BASED ON SAME | 中山大学 | 2022-04-21 | — | — | WO | disclosed |
| US-9206107-B2 | Method for producing carboxylic acid and alcohol by hydrolysis of ester | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2015-12-08 | — | — | US | disclosed |
| US-20140378692-A1 | METHOD FOR PRODUCING CARBOXYLIC ACID AND ALCOHOL BY HYDROLYSIS OF ESTER | NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (JP) | 2014-12-25 | — | — | US | disclosed |
| EP-1303525-B1 | PRODUCTION OF NOVEL PHOSPHANE LIGANDS AND USE IN CATALYTICAL REACTIONS | EVONIK DEGUSSA GMBH (DE) | 2010-09-08 | — | — | EP | disclosed |
| US-7442800-B2 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442800-B2 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442800-B2 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1354887-B1 | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2007-04-25 | — | — | EP | disclosed |
| US-20070073055-A1 | Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations | TOTAL SYNTHESIS, LTD. (CA) | 2007-03-29 | — | — | US | disclosed |
| US-20070073055-A1 | Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations | TOTAL SYNTHESIS, LTD. (CA) | 2007-03-29 | — | — | US | disclosed |
| US-20060287544-A1 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | PROMERUS LLC (US) | 2006-12-21 | — | — | US | disclosed |
| EP-1097158-B1 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1354887-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | Massachusetts Insitute of Technology (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1097158-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000002887-A2 | LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2000-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287544-A1 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)2 for cross-coupling reactions | NDC1, DDC, PDCD1LG2 | MAPK1 3677/4885NLRP3 4335/4885LMNA 4016/4885 |
| US-20140378692-A1 | METHOD FOR PRODUCING CARBOXYLIC ACID AND ALCOHOL BY HYDROLYSIS OF ESTER | ADH5, ADH1C, ADH1A | MAPK1 2320/4885NLRP3 3795/4885LMNA 1884/4885 |
| US-20070073055-A1 | Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations | NDC1, NBAS, NUDC | MAPK1 4384/4885NLRP3 3277/4885LMNA 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.