SCHEMBL296982

SCHEMBL296982

NC(Cc1c(F)cc(O)cc1F)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 3/20 0.53
ALOX15 P16050 3/20 0.53
HSD17B10 Q99714 3/20 0.53
KDM4E B2RXH2 3/20 0.53
HIF1A Q16665 2/20 0.53
RECQL P46063 2/20 0.53
TDP1 Q9NUW8 2/20 0.53
PKM P14618 2/20 0.53
CYP3A4 P08684 2/20 0.53
NFKB1 P19838 2/20 0.53
ALDH1A1 P00352 2/20 0.53
LMNA P02545 2/20 0.53
MAPT P10636 2/20 0.53
BLM P54132 2/20 0.53
PMP22 Q01453 2/20 0.53
KMT2A Q03164 2/20 0.53
NPSR1 Q6W5P4 2/20 0.53
RGS12 O14924 1/20 0.53
CYP2C9 P11712 1/20 0.53
CASP1 P29466 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL296983 1.00 USP2 (0.53) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL29141540 0.92 USP2 (0.46) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL9847981 0.89 USP2 (0.50) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL9851430 0.87 USP2 (0.45) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL5672308 0.87 USP2 (0.50) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL5672304 0.87 USP2 (0.50) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL28551296 0.87 USP2 (0.50) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL20722991 0.84 USP2 (0.47) USP2ALOX15HSD17B10KDM4EHIF1A
SCHEMBL20722707 0.84 USP2 (0.47) USP2ALOX15HSD17B10KDM4EHIF1A
Hydrochloric Acid SCHEMBL20722737 0.82 USP2 (0.46) USP2ALOX15HSD17B10KDM4EHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250161401-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY STEALTH BIOTHERAPEUTICS INC. (US) 2025-05-22 US disclosed
US-20250002530-A1 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME STEALTH BIOTHERAPEUTICS INC. (US) 2025-01-02 US disclosed
US-20240350577-A1 METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING DOMINANT OPTIC ATROPHY STEALTH BIOTHERAPEUTICS INC. (US) 2024-10-24 US disclosed
US-12065511-B2 Aromatic-cationic peptides and uses of same STEALTH BIOTHERAPEUTICS INC. (US) 2024-08-20 US disclosed
US-20240108740-A1 THERAPEUTIC COMPOSITIONS INCLUDING SPN10 AND USES THEREOF STEALTH BIOTHERAPEUTICS INC. (US) 2024-04-04 US disclosed
US-20240059735-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MITOCHONDRIAL MYOPATHIES STEALTH BIOTHERAPEUTICS INC. (US) 2024-02-22 US disclosed
US-20240025949-A1 Beta-Arrestin Effectors and Compositions and Methods of Use Thereof TREVENA, INC. 2024-01-25 US disclosed
EP-4233887-A1 METHODS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY Stealth BioTherapeutics Inc. (US) 2023-08-30 EP disclosed
US-20230109564-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY STEALTH BIOTHERAPEUTICS INC. (US) 2023-04-06 US disclosed
EP-4085920-A1 METHODS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY Stealth BioTherapeutics Inc. (US) 2022-11-09 EP disclosed
EP-1962959-B1 NEUROPEPTIDE-2 RECEPTOR-AGONISTS HOFFMANN LA ROCHE (CH) 2012-03-14 EP disclosed
EP-2326666-A1 NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS AND USES THEREOF F. Hoffmann-La Roche AG (CH) 2011-06-01 EP disclosed
US-20100184701-A1 Beta-Arrestin Effectors And Compositions And Methods Of Use Thereof TREVENA, INC. 2010-07-22 US disclosed
WO-2010077339-A2 β-ARRESTIN EFFECTORS AND COMPOSITIONS AND METHODS OF USE THEREOF TREVENA, INC. (US) 2010-07-08 WO disclosed
WO-2010031707-A1 NEUROPEPTIDE-2 RECEPTOR (Y-2R) AGONISTS AND USES THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2010-03-25 WO disclosed
EP-1962959-A2 NEUROPEPTIDE-2 RECEPTOR-AGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2008-09-03 EP disclosed
US-20070258899-A1 Diagnostic and therapeutic agents KARYON-CTT LTD (FI) 2007-11-08 US disclosed
WO-2007113385-A1 DIAGNOSTIC AND THERAPEUTIC AGENTS KARYON-CTT LTD (FI) 2007-10-11 WO disclosed
WO-2007065808-A2 NEUROPEPTIDE-2 RECEPTOR-AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2007-06-14 WO disclosed
US-20070135351-A1 Neuropeptide-2 receptor (Y-2R) agonists and uses thereof CONDE-KNAPE KARIN 2007-06-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070135351-A1 Neuropeptide-2 receptor (Y-2R) agonists and uses thereof NPY2R, NPY1R, NPY4R USP2 2739/4885ALOX15 1425/4885HSD17B10 1955/4885
US-20250002530-A1 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME ARG2, OAT, PDF USP2 3260/4885ALOX15 2070/4885HSD17B10 2532/4885
US-20250161401-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY MTPN, UTRN, SMN1; SMN2 USP2 1836/4885ALOX15 3907/4885HSD17B10 2525/4885
US-20240059735-A1 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MITOCHONDRIAL MYOPATHIES MTPN, CKMT1A; CKMT1B, TFAM USP2 2999/4885ALOX15 2511/4885HSD17B10 1640/4885
US-20230109564-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY MTPN, UTRN, SMN1; SMN2 USP2 1836/4885ALOX15 3907/4885HSD17B10 2525/4885
US-20070258899-A1 Diagnostic and therapeutic agents YBX1, MLX, TPX2 USP2 3792/4885ALOX15 4182/4885HSD17B10 4778/4885
US-20240108740-A1 THERAPEUTIC COMPOSITIONS INCLUDING SPN10 AND USES THEREOF S100A10, SPG11, TMSB10 USP2 3048/4885ALOX15 3749/4885HSD17B10 2317/4885
US-12065511-B2 Aromatic-cationic peptides and uses of same ARG2, OAT, PDF USP2 3260/4885ALOX15 2070/4885HSD17B10 2532/4885
US-20240350577-A1 METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING DOMINANT OPTIC ATROPHY CRYAA, CRYAB, PRPH USP2 2211/4885ALOX15 1975/4885HSD17B10 2321/4885
US-20240025949-A1 Beta-Arrestin Effectors and Compositions and Methods of Use Thereof ARRB1, FGB, SARS1 USP2 2017/4885ALOX15 3659/4885HSD17B10 3697/4885
US-20100184701-A1 Beta-Arrestin Effectors And Compositions And Methods Of Use Thereof ARRB1, ADRB1, ADRB3 USP2 1527/4885ALOX15 3979/4885HSD17B10 2466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.