Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 1/20 | 0.34 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.34 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.34 |
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.32 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.31 |
| ▸ | DUSP5 | Q16690 | 2/20 | 0.58 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082244 | 0.74 | PTGS2 (0.45) | DUSP5DUSP6LMNATDP1PTPN1 | |
| SCHEMBL30416771 | 0.74 | DUSP5 (1.00) | DUSP5DUSP6LMNATDP1PTPN1 | |
| SCHEMBL28623672 | 0.71 | DUSP5 (0.61) | DUSP5DUSP6LMNATDP1PTPN1 | |
| SCHEMBL28561535 | 0.71 | ALDH1A1 (0.50) | DUSP5DUSP6LMNATDP1PTPN1 | |
| Potassium Ion SCHEMBL28567117 | 0.71 | ALDH1A1 (0.50) | LMNATDP1CA1CA2PKM | |
| SCHEMBL9786187 | 0.69 | DUSP5 (0.59) | DUSP5DUSP6LMNATDP1KMT2A | |
| Potassium Ion SCHEMBL2956793 | 0.69 | KMT2A (0.58) | DUSP5DUSP6LMNATDP1KMT2A | |
| Potassium Ion SCHEMBL9220931 | 0.68 | PTPN1 (0.50) | DUSP5DUSP6LMNATDP1PTPN1 | |
| SCHEMBL124132 | 0.68 | DUSP5 (0.54) | DUSP5DUSP6LMNATDP1PTPN1 | |
| SCHEMBL29664952 | 0.68 | DUSP5 (0.85) | DUSP5DUSP6LMNATDP1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025014777-A1 | INHIBITION OF CLIC1 TO TREAT OBESITY AND HEART FAILURE | CLICBIO, INC. (US) | 2025-01-16 | — | — | WO | claimed |
| WO-2025014777-A1 | INHIBITION OF CLIC1 TO TREAT OBESITY AND HEART FAILURE | CLICBIO, INC. (US) | 2025-01-16 | — | — | WO | disclosed |