Ensulizole

Ensulizole

SCHEMBL3173641

O=S(=O)([O-])c1ccc2[nH]c(-c3ccccc3)nc2c1.[Na+]

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Ensulizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPBWR1 P48145 3/20 0.58
HDAC6 Q9UBN7 1/20 0.58
SCD O00767 1/20 0.56
NPC1 O15118 3/20 0.54
RAB9A P51151 3/20 0.54
GAA P10253 2/20 0.54
CYP2C9 P11712 3/20 0.52
CYP2C19 P33261 3/20 0.52
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 3/20 0.50
CYP2D6 P10635 1/20 0.50
MAPT P10636 9/20 0.48
TP53 P04637 5/20 0.48
MMP2 P08253 1/20 0.48
MMP9 P14780 1/20 0.48
MMP8 P22894 1/20 0.48
MMP13 P45452 1/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
CHEK2 O96017 1/20 0.47
KDM4E B2RXH2 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ensulizole SCHEMBL2142370 0.97 NPBWR1 (0.58) NPBWR1HDAC6SCDNPC1RAB9A
Ensulizole SCHEMBL3173657 0.88 NPBWR1 (0.74) NPBWR1HDAC6SCDNPC1RAB9A
Ensulizole SCHEMBL27885503 0.86 HDAC6 (0.75) NPBWR1HDAC6SCDNPC1RAB9A
Ensulizole SCHEMBL29405567 0.85 HDAC6 (0.79) NPBWR1HDAC6SCDNPC1RAB9A
Ensulizole SCHEMBL16277 0.85 HDAC6 (0.79) NPBWR1HDAC6SCDNPC1RAB9A
Ensulizole SCHEMBL17707525 0.85 NPBWR1 (0.74) NPBWR1HDAC6SCDNPC1RAB9A
SCHEMBL12568424 0.85 NPBWR1 (0.79) NPBWR1HDAC6SCDCYP2C9CYP2C19
SCHEMBL15640415 0.85 CHEK2 (0.63) NPBWR1HDAC6SCDNPC1RAB9A
Ensulizole SCHEMBL4619449 0.85 HDAC6 (0.79) NPBWR1HDAC6SCDNPC1RAB9A
SCHEMBL516958 0.85 NPBWR1 (0.58) NPBWR1HDAC6SCDNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107629310-B Supermolecule intercalation structure light stabilizer and preparation method thereof 北京化工大学 2020-07-24 CN claimed
US-10111825-B2 Oil-in-water emulsions enriched with salt which are highly viscous and stable over time SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) 2018-10-30 US claimed
EP-2787960-B1 NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT WHICH ARE HIGHLY VISCOUS AND STABLE OVER TIME SOC D'EXPLOITATION DE PRODUITS POUR LES IND CHIMIQUES SEPPIC (FR) 2017-09-06 EP claimed
CN-103987372-B Use natural gum stable, high viscosity and the most stable new O/w emulsion rich in salt 化工产品开发公司SEPPIC 2016-08-17 CN claimed
EP-2787961-B1 NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT, WHICH ARE STABILIZED USING NATURAL GUMS, HIGHLY VISCOUS, AND STABLE OVER TIME SOCIÉTÉ D EXPL DE PRODUITS POUR LES IND CHIMIQUES SEPPIC (FR) 2016-04-13 EP claimed
US-20150335567-A1 NOVEL OIL-IN-WATER EMULSIONS RICH IN SALTS, HAVING HIGH VISCOSITY AND STABLE OVER TIME SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) 2015-11-26 US claimed
US-20140350125-A1 NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT, WHICH ARE STABILIZED USING NATURAL GUMS, HIGHLY VISCOUS, AND STABLE OVER TIME SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC (FR) 2014-11-27 US claimed
CN-104168878-A Novel oil-in-water emulsions enriched with salt which are highly viscous and stable over time SEPPIC SA 2014-11-26 CN claimed
US-20140335039-A1 NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT WHICH ARE HIGHLY VISCOUS AND STABLE OVER TIME SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUS- TRIES CHIMIQUES SEPPIC (FR) 2014-11-13 US claimed
CN-103987372-A Novel oil-in-water emulsions enriched with salt, which are stabilized using natural gums, highly viscous, and stable over time SEPPIC SA 2014-08-13 CN claimed
EP-1490018-A2 SUNSCREEN COMPOSITIONS AND METHODS AND MATERIALS FOR PRODUCING THE SAME The C.P. Hall Company (US) 2004-12-29 EP claimed
WO-2003075877-A2 SUNSCREEN COMPOSITIONS AS WELL AS METHODS AND MATERIALS FOR PRODUCING THE SAME, WHEREIN THE PHOTODECAY RATE OF THE FILTER SYSTEM IS REDUCED BY CONTROLLING THE POLARITY OF THE SOLVENT SYSTEM THE C.P. HALL COMPANY (US) 2003-09-18 WO claimed
US-6485713-B1 CONTROLLING THE POLARITY OF A SOLVENT SYSTEM IN THE COMPOSITION TO CONTROL THE RATE OF PHOTODECAY OF A FILTER SYSTEM IN THE COMPOSITION THE C. P. HALL COMPANY 2002-11-26 US claimed
CN-1189095-A Multi-phase light screening agent, process for its production and for its application to skin LANCASTER GROUP AG (DE) 1998-07-29 CN claimed
US-4584190-A AROMATIC, UNSATURATED, OXO, OXYESTER KAO CORPORATION (JP) 1986-04-22 US claimed
JP-10175839-A None JP disclosed
US-11896695-B2 Cosmetic compositions THE BOOTS COMPANY PLC (GB) 2024-02-13 US disclosed
EP-0154928-A2 Long wavelength ultraviolet ray absorber Kao Corporation (JP) 1985-09-18 EP disclosed
US-4489057-A DIBENZOYLMETHANE COMPOUNDS MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1984-12-18 US disclosed
US-4466805-A 1,1,6,6-TETRAALKOXY HEXA-2,4-DIENES MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1984-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11896695-B2 Cosmetic compositions POLL, PCNA, POLI NPBWR1 2243/4885HDAC6 2737/4885SCD 281/4885
US-20140350125-A1 NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT, WHICH ARE STABILIZED USING NATURAL GUMS, HIGHLY VISCOUS, AND STABLE OVER TIME CUTA, ALG1, ACACA NPBWR1 2795/4885HDAC6 2407/4885SCD 346/4885
US-20150335567-A1 NOVEL OIL-IN-WATER EMULSIONS RICH IN SALTS, HAVING HIGH VISCOSITY AND STABLE OVER TIME ALG1, SGMS1, SGMS2 NPBWR1 758/4885HDAC6 1851/4885SCD 83/4885
US-10111825-B2 Oil-in-water emulsions enriched with salt which are highly viscous and stable over time ALG1, MGAT3, MGAT1 NPBWR1 1909/4885HDAC6 1575/4885SCD 850/4885
US-20140335039-A1 NOVEL OIL-IN-WATER EMULSIONS ENRICHED WITH SALT WHICH ARE HIGHLY VISCOUS AND STABLE OVER TIME ALG1, MGAT3, CSGALNACT1 NPBWR1 1718/4885HDAC6 1675/4885SCD 685/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.