Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.35 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093639 | 0.77 | GABBR2 (0.39) | GABBR2GABRR1GABBR1LPAR3LPAR2 | |
| SCHEMBL8093644 | 0.75 | GABBR2 (0.42) | GABBR2GABRR1GABBR1MMP1MMP2 | |
| SCHEMBL9583701 | 0.70 | FAAH (0.43) | GABBR2GABRR1GABBR1LPAR3LPAR2 | |
| SCHEMBL7118204 | 0.68 | TRPM8 (0.42) | GABBR2GABRR1GABBR1MMP1MMP2 | |
| SCHEMBL18378082 | 0.68 | TRPM8 (0.42) | GABBR2GABRR1GABBR1MMP1MMP2 | |
| SCHEMBL29019122 | 0.68 | TRPM8 (0.42) | GABBR2GABRR1GABBR1MMP1MMP2 | |
| SCHEMBL28932690 | 0.67 | PPARD (0.34) | LPAR3LPAR2 | |
| SCHEMBL3967242 | 0.67 | CYP3A4 (0.54) | LPAR3LPAR2HPGDSMN1; SMN2LPAR1 | |
| SCHEMBL14975431 | 0.67 | CYP3A4 (0.54) | LPAR3LPAR2HPGDSMN1; SMN2LPAR1 | |
| SCHEMBL672113 | 0.67 | CYP3A4 (0.54) | LPAR3LPAR2HPGDSMN1; SMN2LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118558319-A | Silica supported by ultra-small nanoparticles of a first metal or metal oxide or a second metal and method for preparing same | 新特能源股份有限公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-3374463-B1 | COOLANT CONCENTRATE CONTAINING SILICATE | ROWE HOLDING GMBH (DE) | 2023-03-01 | — | — | EP | disclosed |
| US-8786936-B2 | Ink compositions, methods of preparing ink compositions and display panels including ink compositions | NOROO HOLDINGS CO., LTD. (KR) | 2014-07-22 | — | — | US | disclosed |
| US-20130170014-A1 | INK COMPOSITIONS, METHODS OF PREPARING INK COMPOSITIONS AND DISPLAY PANELS INCLUDING INK COMPOSITIONS | NOROO PAINT & COATINGS CO., LTD. (KR) | 2013-07-04 | — | — | US | disclosed |
| US-7645331-B2 | corrosion resistant composition contains a water soluble polyelectrolyte polymer dispersant and a tri or tetracarboxylic acid; antifreezes; for use in vehicle cooling systems | HONEYWELL INTERNATIONAL INC. (US) | 2010-01-12 | — | — | US | disclosed |