SCHEMBL3264357

SCHEMBL3264357

C=C(C#N)C(=O)OCC=CF

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.53
TSHR P16473 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1922594 0.88 ALDH1A1 (0.61) ALDH1A1TSHR
SCHEMBL1922593 0.88 ALDH1A1 (0.61) ALDH1A1TSHR
SCHEMBL4893994 0.81 TSHR (0.58) ALDH1A1TSHR
SCHEMBL4894000 0.81 TSHR (0.58) ALDH1A1TSHR
SCHEMBL11500859 0.81 ALDH1A1 (0.53) ALDH1A1TSHR
SCHEMBL5477393 0.80 ALDH1A1 (0.52) ALDH1A1TSHR
SCHEMBL2529844 0.79 ALDH1A1 (0.55) ALDH1A1TSHR
SCHEMBL29209395 0.79 ALDH1A1 (0.59) ALDH1A1TSHR
SCHEMBL30940 0.79 TSHR (0.59) ALDH1A1TSHR
SCHEMBL25418423 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007118807-A2 COSMETIC COMPOSITION COMPRISING, IN A COSMETIC MEDIUM, AT LEAST ONE SILICA PARTICLE, AT LEAST ONE CYANOACRYLATE MONOMER AND AT LEAST ONE LIQUID ORGANIC SOLVENT L'ORÉAL (FR) 2007-10-25 WO claimed
WO-2007057780-A2 METHOD FOR MAKE-UP OR CARE OF KERATINOUS MATERIALS WITH ELECTROPHILIC MONOMER L'OREAL (FR) 2007-05-24 WO claimed
US-20060115445-A1 Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents L'OREAL S.A. (FR) 2006-06-01 US claimed
US-20060110334-A1 Two-compartment aerosol device comprising electrophilic monomers, and use thereof for the cosmetic treatment of the hair L'OREAL S.A. (FR) 2006-05-25 US claimed
US-20060088493-A1 Composition and process for the cosmetic treatment of keratin materials based on electrophilic monomers and non-silicone polymers L'OREAL S.A. (FR) 2006-04-27 US claimed
US-20060083706-A1 Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant L'OREAL S.A. (FR) 2006-04-20 US claimed
US-20060080792-A1 Film-forming composition for the cosmetic treatment of keratin materials comprising at least one electrophilic monomer and at least one non-silicone polymer L'OREAL S.A. (FR) 2006-04-20 US claimed
US-20060083762-A1 Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles L'OREAL S.A. (FR) 2006-04-20 US claimed
US-20060078523-A1 Composition comprising at least one electrophilic monomer and at least one acid in a cosmetically acceptable anhydrous medium, and use thereof for cosmetic treatment of the hair L'OREAL S.A. (FR) 2006-04-13 US claimed
US-20060078522-A1 Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt L'OREAL S.A. (FR) 2006-04-13 US claimed
US-20100172858-A1 COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER OBTAINED FROM A DIELECTROPHILIC MONOMER L'OREAL S.A. (FR) 2010-07-08 US disclosed
US-7621966-B2 Cosmetic composition comprising at least one pigment and/or at least one filler surface-treated beforehand with at least one organic agent and at least one electrophilic monomer L'OREAL S.A. (FR) 2009-11-24 US disclosed
US-20080038218-A1 Cosmetic composition comprising at least one electrophilic monomer, at least one fluoro compound and at least one liquid organic solvent L'OREAL S.A. (FR) 2008-02-14 US disclosed
US-20080019934-A1 Water-in-oil emusions for the treatment of keratin fibers, comprising at least one cyanoacrylate monomer and aqueous ammonia L'OREAL S.A. (FR) 2008-01-24 US disclosed
US-20070261179-A1 Cosmetic composition comprising at least one polymerizable cyanoacrylate monomer and at least one conditioning agent and/or at least one particular additional compound, for improving the color of artificially dyed keratin fibers L'OREAL S.A. (FR) 2007-11-15 US disclosed
US-20060088493-A1 Composition and process for the cosmetic treatment of keratin materials based on electrophilic monomers and non-silicone polymers L'OREAL S.A. (FR) 2006-04-27 US disclosed
US-20060083706-A1 Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant L'OREAL S.A. (FR) 2006-04-20 US disclosed
US-20060083762-A1 Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles L'OREAL S.A. (FR) 2006-04-20 US disclosed
US-20060080792-A1 Film-forming composition for the cosmetic treatment of keratin materials comprising at least one electrophilic monomer and at least one non-silicone polymer L'OREAL S.A. (FR) 2006-04-20 US disclosed
US-20060078522-A1 Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt L'OREAL S.A. (FR) 2006-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080038218-A1 Cosmetic composition comprising at least one electrophilic monomer, at least one fluoro compound and at least one liquid organic solvent KRT18, CUTA, FLNA ALDH1A1 828/4885TSHR 3393/4885
US-20060110334-A1 Two-compartment aerosol device comprising electrophilic monomers, and use thereof for the cosmetic treatment of the hair POLR1C, TRPA1, GSTM2 ALDH1A1 492/4885TSHR 4318/4885
US-20060088493-A1 Composition and process for the cosmetic treatment of keratin materials based on electrophilic monomers and non-silicone polymers KRT18, CUTA, MARK1 ALDH1A1 3552/4885TSHR 4581/4885
US-20060083762-A1 Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles KRT18, PRKDC, ACP1 ALDH1A1 828/4885TSHR 4297/4885
US-20060115445-A1 Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents KRT18, PRKDC, CUTA ALDH1A1 1395/4885TSHR 4246/4885
US-20100172858-A1 COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER OBTAINED FROM A DIELECTROPHILIC MONOMER KRT18, DSG1, DSC1 ALDH1A1 320/4885TSHR 4403/4885
US-20080019934-A1 Water-in-oil emusions for the treatment of keratin fibers, comprising at least one cyanoacrylate monomer and aqueous ammonia KRT18, EPCAM, CDH1 ALDH1A1 1954/4885TSHR 4813/4885
US-20060083706-A1 Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant MITF, CUTA, NACA ALDH1A1 43/4885TSHR 3327/4885
US-20060078523-A1 Composition comprising at least one electrophilic monomer and at least one acid in a cosmetically acceptable anhydrous medium, and use thereof for cosmetic treatment of the hair HOGA1, OAT, SUCLG1 ALDH1A1 18/4885TSHR 4459/4885
US-20060078522-A1 Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt KRT18, DSG1, DSC1 ALDH1A1 1453/4885TSHR 4360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.