SCHEMBL3304004

SCHEMBL3304004

Fc1cc(F)cc(C[Zn]Br)c1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.41
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA9 Q16790 1/20 0.33
TAAR1 Q96RJ0 1/20 0.32
AGXT P21549 2/20 0.31
CYP17A1 P05093 1/20 0.31
CYP21A2 P08686 1/20 0.31
CYP11B1 P15538 1/20 0.31
DAO P14920 1/20 0.31
DBH P09172 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31750006 0.81 RXRA (0.41) IDO1TAAR1
SCHEMBL3734 0.78 TAAR1 (0.52) IDO1TAAR1AGXT
SCHEMBL5201 0.76 IDO1 (0.48) IDO1TAAR1AGXT
SCHEMBL12466515 0.74 IDO1 (0.41) IDO1CA12CA1CA9TAAR1
SCHEMBL14270585 0.71 IDO1 (0.48) IDO1CA12CA1CA9TAAR1
SCHEMBL1300421 0.70 HTT (0.42) CYP17A1CYP11B1DAO
SCHEMBL5487052 0.69 IDO1 (0.46) IDO1CA12CA1CA9TAAR1
SCHEMBL120092 0.69 IDO1 (0.46) IDO1CA12CA1CA9TAAR1
SCHEMBL5733912 0.69 IDO1 (0.46) IDO1CA12CA1CA9TAAR1
SCHEMBL16105495 0.67 IDO1 (0.50) IDO1CA12CA1CA9TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12636279-B2 Choline salt forms of an HIV capsid inhibitor GILEAD SCIENCES, INC. (US) 2026-05-26 US disclosed
EP-4041393-B1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AG (DE) 2026-04-08 EP disclosed
US-12594267-B2 Capsid inhibitors for the treatment of HIV GILEAD SCIENCES, INC. (US) 2026-04-07 US disclosed
US-12492189-B2 Solid forms of an HIV capsid inhibitor GILEAD SCIENCES, INC. (US) 2025-12-09 US disclosed
EP-4172157-B1 CAPSID INHIBITORS FOR THE TREATMENT OF HIV GILEAD SCIENCES INC (US) 2025-11-19 EP disclosed
CN-114901280-B MrgprX2 antagonists and uses thereof 德米拉公司 2025-05-27 CN disclosed
US-20240376077-A1 THERAPEUTIC COMPOUNDS GILEAD SCIENCES, INC. 2024-11-14 US disclosed
EP-4458415-A2 SOLID FORMS OF AN HIV CAPSID INHIBITOR Gilead Sciences, Inc. (US) 2024-11-06 EP disclosed
CN-114867529-B Novel heteroaryl triazole compounds as pesticides 拜耳公司 2024-09-27 CN disclosed
US-20240316018-A1 CAPSID INHIBITORS FOR THE TREATMENT OF HIV GILEAD SCIENCES, INC. 2024-09-26 US disclosed
WO-2014110297-A1 (HETERO) ARYLACETAMIDE DERIVATIVES AS ANTIRETROVIRAL AGENTS GILEAD SCIENCES, INC. (US) 2014-07-17 WO disclosed
WO-2013164292-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-11-07 WO disclosed
US-20130289074-A1 NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-10-31 US disclosed
WO-2010045013-A1 PHENYL SUBSTITUTED THIENO [2,3-D] PYRIMIDINES AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2010-04-22 WO disclosed
US-20100093763-A1 PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2010-04-15 US disclosed
US-20080009478-A1 Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases ARENA PHARMACEUTICALS, INC. (US) 2008-01-10 US disclosed
WO-2005042491-A1 BENZAZEPINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES ARENA PHARMACEUTICALS, INC. (US) 2005-05-12 WO disclosed
US-6593480-B2 Obesity, hyperglycemia ABBOTT LABORATORIES 2003-07-15 US disclosed
WO-2002070507-A2 GLYCORTICOID RECEPTOR ANTAGONISTS FOR TREATMENT OF DIABETES ABBOTT LABORATORIES (US) 2002-09-12 WO disclosed
US-20010041802-A1 Glucocorticoid receptor antagonists for treatment of diabetes KARO BIO AB (SE) 2001-11-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080009478-A1 Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases HTR2C, HTR2A, HTR2B IDO1 267/4885CA12 4193/4885CA1 4401/4885
US-20010041802-A1 Glucocorticoid receptor antagonists for treatment of diabetes NR3C1, GPR119, NR3C2 IDO1 3967/4885CA12 4817/4885CA1 4656/4885
US-20240316018-A1 CAPSID INHIBITORS FOR THE TREATMENT OF HIV SAP18, SLC11A2, CD4 IDO1 2494/4885CA12 1441/4885CA1 2784/4885
US-12636279-B2 Choline salt forms of an HIV capsid inhibitor CHKA, SLC5A7, SLC44A1 IDO1 547/4885CA12 3032/4885CA1 668/4885
US-12594267-B2 Capsid inhibitors for the treatment of HIV CTDSP1, POLR2H, POLR2E IDO1 2581/4885CA12 3348/4885CA1 2933/4885
US-12492189-B2 Solid forms of an HIV capsid inhibitor ZC3HAV1, GTF3C3, ZC3HAV1L IDO1 1113/4885CA12 3910/4885CA1 1544/4885
US-20240376077-A1 THERAPEUTIC COMPOUNDS HAVCR2, MAVS, EIF2AK2 IDO1 3387/4885CA12 3010/4885CA1 4509/4885
US-20130289074-A1 NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS GPR119, GPR55, GPR52 IDO1 605/4885CA12 2489/4885CA1 3179/4885
US-20100093763-A1 PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS ADORA2A, ADORA3, ADORA2B IDO1 409/4885CA12 4877/4885CA1 4704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.