Water

Water

SCHEMBL338049

O.O=S(=O)(O)c1ccc(Cl)cc1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 known ✓ P03956 1/20 0.54
MMP8 known ✓ P22894 1/20 0.54
MMP13 known ✓ P45452 1/20 0.54
MEN1 known ✓ O00255 1/20 0.48
FLT1 known ✓ P17948 1/20 0.45
FLT4 known ✓ P35916 1/20 0.45
KDR known ✓ P35968 1/20 0.45
ALDH1A1 P00352 3/20 0.59
CYP3A4 P08684 1/20 0.59
MAPK1 P28482 1/20 0.59
LMNA P02545 1/20 0.56
CA1 P00915 4/20 0.54
CA2 P00918 4/20 0.54
CA12 O43570 3/20 0.54
CA3 P07451 3/20 0.54
CA4 P22748 3/20 0.54
CA6 P23280 3/20 0.54
CA5A P35218 3/20 0.54
CA7 P43166 3/20 0.54
CA9 Q16790 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL11037456 1.00 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL8477054 0.97 ALDH1A1 (0.62) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL26836 0.97 ALDH1A1 (0.62) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL8746207 0.97 ALDH1A1 (0.62) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL125764 0.95 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL6568407 0.95 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1
Ammonia Solution, Strong SCHEMBL11740925 0.95 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL8720147 0.95 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL6908111 0.95 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1
SCHEMBL6913648 0.95 ALDH1A1 (0.59) ALDH1A1CYP3A4MAPK1LMNACA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0592875-A1 Process for producing dichlorodiphenylsulfone UBE INDUSTRIES, LTD. (JP) 1994-04-20 EP claimed
JP-6172298-A None JP disclosed
US-20240058452-A1 PHARMACEUTICAL COMPOSITION CONTAINING TEMPERATURE-RESPONSIVE IONIC LIQUID TORAY INDUSTRIES, INC. (JP) 2024-02-22 US disclosed
CN-117050013-A Mono (acid) salts of 6-aminoisoquinolines and use thereof 爱瑞制药公司 2023-11-14 CN disclosed
CN-111936139-B Mono (acid) salts of 6-aminoisoquinolines and use thereof 爱瑞制药公司 2023-10-13 CN disclosed
CN-114502142-B Pharmaceutical composition comprising temperature responsive ionic liquid 东丽株式会社 2023-05-09 CN disclosed
EP-4043007-A1 PHARMACEUTICAL COMPOSITION INCLUDING TEMPERATURE-RESPONSIVE IONIC LIQUID Toray Industries, Inc. (JP) 2022-08-17 EP disclosed
CN-114502142-A Pharmaceutical compositions comprising temperature-responsive ionic liquids 东丽株式会社 2022-05-13 CN disclosed
US-20220144778-A1 MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF ALCON INC. (CH) 2022-05-12 US disclosed
WO-2021070893-A1 PHARMACEUTICAL COMPOSITION INCLUDING TEMPERATURE-RESPONSIVE IONIC LIQUID 東レ株式会社 2021-04-15 WO disclosed
US-20100092885-A1 IMAGE FORMING MATERIAL FUJI XEROX CO., LTD. (JP) 2010-04-15 US disclosed
CN-101685252-A Image forming material FUJI XEROX CO LTD 2010-03-31 CN disclosed
US-20100071592-A1 IMAGE-FORMING MATERIAL FUJI XEROX CO., LTD. (JP) 2010-03-25 US disclosed
US-20090227793-A1 IMAGE-FORMING MATERIAL FUJI XEROX CO., LTD. (JP) 2009-09-10 US disclosed
CN-101526764-A Image forming material FUJI XEROX CO LTD 2009-09-09 CN disclosed
US-6353074-B1 HYDROLYTIC CONDENSATION OF TRICHLOROSILANE IN TWO-PHASE SYSTEM CONSISTING OF AQUEOUS PHASE AND ORGANIC PHASE DOW CORNING CORPORATION 2002-03-05 US disclosed
EP-1002823-A1 Method for manufacturing hydrogen-silsesquioxane resin Dow Corning Asia, Ltd. (JP) 2000-05-24 EP disclosed
JP-H06172298-A PRODUCTION OF DICHLRODIPHENYLSULFONE UBE IND LTD 1994-06-21 JP disclosed
EP-0592875-A1 Process for producing dichlorodiphenylsulfone UBE INDUSTRIES, LTD. (JP) 1994-04-20 EP disclosed
EP-0592875-A1 Process for producing dichlorodiphenylsulfone UBE INDUSTRIES, LTD. (JP) 1994-04-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227793-A1 IMAGE-FORMING MATERIAL PLIN5, PLIN1, SEPTIN7 MMP1 900/4885MMP8 3886/4885MMP13 3730/4885
US-20100071592-A1 IMAGE-FORMING MATERIAL PLIN5, PLIN1, SEPTIN7 MMP1 1855/4885MMP8 4266/4885MMP13 4310/4885
US-20240058452-A1 PHARMACEUTICAL COMPOSITION CONTAINING TEMPERATURE-RESPONSIVE IONIC LIQUID SULT1A1, CYP2C19, SULT2A1 MMP1 4509/4885MMP8 4848/4885MMP13 4371/4885
US-20100092885-A1 IMAGE FORMING MATERIAL SEPTIN7, SEPTIN2, PLIN5 MMP1 867/4885MMP8 3542/4885MMP13 3126/4885
US-20220144778-A1 MONO-(ACID) SALTS OF 6-AMINOISOQUINOLINES AND USES THEREOF AADAT, SLC10A1, SLC10A2 MMP1 3881/4885MMP8 2907/4885MMP13 4331/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.