Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylephedrine SCHEMBL99674 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL907777 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL7496690 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL338479 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL2712293 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL11959977 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL907677 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL99673 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL8083321 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1AOC3GAAADRA2C | |
| Methylephedrine SCHEMBL68363 | 0.98 | ALDH1A1 (0.96) | KDM4EALDH1A1AOC3GAAADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627627-B1 | PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-09 | — | — | EP | claimed |
| US-11059799-B2 | Process for preparation of eribulin and intermediates thereof | DR. REDDY'S LABORATORIES LIMITED. (IN) | 2021-07-13 | — | — | US | disclosed |
| US-10836776-B2 | Process for preparation of eribulin and intermediates thereof | DR. REDDY'S LABORATORIES LIMITED (IN) | 2020-11-17 | — | — | US | disclosed |
| US-20190276470-A1 | PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-09-12 | — | — | US | disclosed |
| US-20190177291-A1 | PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-06-13 | — | — | US | disclosed |
| WO-2017203459-A1 | PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF | DR. REDDY'S LABORATORIES LIMITED (IN) | 2017-11-30 | — | — | WO | disclosed |
| EP-2627627-B1 | PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-3124490-A1 | HIGH STABILITY POLYIONIC LIQUID SALTS | Sigma-Aldrich Co. LLC (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2627643-B1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | BRISTOL MYERS SQUIBB CO (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160326101-A1 | Process for the Synthesis of Chiral Propargylic Alcohols | BRISTOL MYERS SQUIBB CO (US) | 2016-11-10 | — | — | US | disclosed |
| WO-2012048886-A1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | LONZA LTD (CH) | 2012-04-19 | — | — | WO | disclosed |
| WO-2012048887-A1 | PROCESS FOR THE SYNTHESIS OF CHIRAL PROPARGYLIC ALCOHOLS | LONZA LTD (CH) | 2012-04-19 | — | — | WO | disclosed |
| WO-2012048884-A1 | PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES | LONZA LTD (CH) | 2012-04-19 | — | — | WO | disclosed |
| US-20120083603-A1 | HIGH STABILITY POLYIONIC LIQUID SALTS | SIGMA-ALDRICH CO. LLC (US) | 2012-04-05 | — | — | US | disclosed |
| US-8097721-B2 | polycationic or polyanionic molecules; use as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry (ESI-MS); thermal stability; tris(anion) such as tris(sulfonate) or tris(cation) groups such as imidazolium, pyrrolidinium, ammonium | SIGMA-ALDRICH CO. LLC (US) | 2012-01-17 | — | — | US | disclosed |
| US-20110294819-A1 | Hepatitis C Virus Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2011-12-01 | — | — | US | disclosed |
| US-20110009648-A1 | Carbonyl Asymmetric Alkylation | SANDOZ AG (CH) | 2011-01-13 | — | — | US | disclosed |
| US-20110009648-A1 | Carbonyl Asymmetric Alkylation | SANDOZ AG (CH) | 2011-01-13 | — | — | US | disclosed |
| US-20090163728-A1 | Processes for Highly Enantio- and Diastereoselective Synthesis of Acyclic Epoxy Alcohols and Allylic Epoxy Alcohols | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-06-25 | — | — | US | disclosed |
| US-20080210858-A1 | High Stability Polyionic Liquid Salts | SIGMA-ALDRICH CO. NEWCO INC. | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11059799-B2 | Process for preparation of eribulin and intermediates thereof | ERLIN1, ERLIN2, MAN1B1 | KDM4E 3375/4885ALDH1A1 1325/4885AOC3 3546/4885 |
| US-20160326101-A1 | Process for the Synthesis of Chiral Propargylic Alcohols | ADH1C, ADH1A, ADH5 | KDM4E 2173/4885ALDH1A1 49/4885AOC3 1021/4885 |
| US-10836776-B2 | Process for preparation of eribulin and intermediates thereof | ERLIN1, ERLIN2, DHPS | KDM4E 2804/4885ALDH1A1 1861/4885AOC3 4182/4885 |
| US-20110294819-A1 | Hepatitis C Virus Inhibitors | HAVCR2, MAVS, GTF3C1 | KDM4E 3330/4885ALDH1A1 3778/4885AOC3 3412/4885 |
| US-20080210858-A1 | High Stability Polyionic Liquid Salts | PUF60, POLI, PARG | KDM4E 4398/4885ALDH1A1 4720/4885AOC3 4342/4885 |
| US-20190177291-A1 | PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF | ERLIN1, ERLIN2, MAN1B1 | KDM4E 3375/4885ALDH1A1 1325/4885AOC3 3546/4885 |
| US-20120083603-A1 | HIGH STABILITY POLYIONIC LIQUID SALTS | PUF60, POLI, PARG | KDM4E 4398/4885ALDH1A1 4720/4885AOC3 4342/4885 |
| US-20110009648-A1 | Carbonyl Asymmetric Alkylation | COASY, ADH5, SI | KDM4E 880/4885ALDH1A1 53/4885AOC3 345/4885 |
| US-20190276470-A1 | PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF | ERLIN1, ERLIN2, DHPS | KDM4E 2804/4885ALDH1A1 1861/4885AOC3 4182/4885 |
| US-20090163728-A1 | Processes for Highly Enantio- and Diastereoselective Synthesis of Acyclic Epoxy Alcohols and Allylic Epoxy Alcohols | ADH1C, ADH1A, ADH5 | KDM4E 912/4885ALDH1A1 20/4885AOC3 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.