Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Sulfurous Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.36 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfurous Acid SCHEMBL223079 | 1.00 | — | — | |
| Sulfurous Acid SCHEMBL7998800 | 1.00 | ALDH1A1 (0.39) | ALDH1A1CA1CA2 | |
| Sulfurous Acid SCHEMBL3409994 | 0.96 | ALDH1A1 (0.36) | ALDH1A1CA1CA2 | |
| Sulfurous Acid SCHEMBL5666129 | 0.96 | ALDH1A1 (0.36) | ALDH1A1CA1CA2 | |
| Sulfurous Acid SCHEMBL8428444 | 0.86 | ALDH1A1 (0.33) | ALDH1A1CA1CA2 | |
| Sulfurous Acid SCHEMBL29410199 | 0.83 | CA1 (0.50) | CA1CA2 | |
| Sulfurous Acid SCHEMBL889 | 0.83 | — | — | |
| Sulfurous Acid SCHEMBL1533868 | 0.83 | CA1 (0.50) | CA1CA2 | |
| Sulfurous Acid SCHEMBL453622 | 0.81 | — | — | |
| Sulfurous Acid SCHEMBL25405107 | 0.79 | CA1 (0.46) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4184929-A | FORMALDEHYDE OR GLYOXAL, OR BISULFITE OR SULOXYLATE SALTS THEREOF AS EDUCING AGENTS | OXY METAL INDUSTRIES CORPORATION (US) | 1980-01-22 | — | — | US | claimed |
| US-20100094021-A1 | NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES | KALYPSYS, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20080293942-A1 | Methods of Preparing 2-Imidazol-1-Yl-4-Methyl-6-Pyrrolidin-2-Yl-Pyrimidine and 4-(1-Alkylpyrrolidin-2-Yl)-2-(1H-Imidazol-1-Yl)-6-Methylpyrimidine Derivatives | COUSINS RUSSELL D | 2008-11-27 | — | — | US | disclosed |
| EP-1954695-A1 | NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5-YL)-DIALKYL-AMINES | Kalypsys, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062411-A1 | NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5-YL)-DIALKYL-AMINES | KALYPSYS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007062417-A1 | METHODS OF PREPARING 2-IMIDAZOL-1-YL-4-METHYL-6-PYRROLIDIN-2-YL-PYRIMIDINE AND 4-(1-ALKYLPYRROLIDIN-2-YL)-2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDINE DERIVATIVES | KALYPSYS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| US-20070123572-A1 | NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES | KALYPSYS, INC. (US) | 2007-05-31 | — | — | US | disclosed |
| WO-2006119104-A2 | PROCESS FOR PREPARING ISATINS WITH CONTROL OF SIDE-PRODUCT FORMATION | WYETH (US) | 2006-11-09 | — | — | WO | disclosed |
| US-20060247442-A1 | Process for preparing isatins with control of side-product formation | WYETH (US) | 2006-11-02 | — | — | US | disclosed |
| EP-0735852-B1 | LIQUID DISPENSER FOR STERILE SOLUTIONS | BIOPOLYMERIX INC (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5869073-A | APPLYING NON-LEACHABLE COATING ON SURFACE FROM SOLUTION, DISPERSION OR SUSPENSION OF A BIGUANIDE POLYMER REACTED WITH A CROSSLINKING AGENT TO FORM AN ADDUCT AND AN ANTIMICROBIAL METAL MATERIAL | BIOPOLYMERIX, INC (GB) | 1999-02-09 | — | — | US | disclosed |
| EP-0891712-A1 | Liquid dispenser for sterile solutions | BIOPOLYMERIX, INC. (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5681468-A | POLYCATIONIC POLYMERIC MATERIAL AND METAL SALT | BIOPOLYMERIX, INC. (US) | 1997-10-28 | — | — | US | disclosed |
| EP-0735852-A1 | LIQUID DISPENSER FOR STERILE SOLUTIONS | BIOPOLYMERIX, INC. (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5490938-A | HAVING FILTER COATED WITH BACTERIOSTATIC OR BACTERICIDAL SILVER CONTAINING MATERIAL | BIOPOLYMERIX, INC. (US) | 1996-02-13 | — | — | US | disclosed |
| WO-1995017152-A1 | LIQUID DISPENSER FOR STERILE SOLUTIONS | BIOPOLYMERIX, INC. (US) | 1995-06-29 | — | — | WO | disclosed |
| US-4684483-A | FROM GLYOXAL, AMINE, SULFUR DIOXIDE | MONSANTO COMPANY (US) | 1987-08-04 | — | — | US | disclosed |
| US-4184929-A | FORMALDEHYDE OR GLYOXAL, OR BISULFITE OR SULOXYLATE SALTS THEREOF AS EDUCING AGENTS | OXY METAL INDUSTRIES CORPORATION (US) | 1980-01-22 | — | — | US | disclosed |
| US-4125402-A | Method of processing silver dye bleaching materials and preparations suitable for the dye and silver bleaching | CIBA-GEIGY AG (CH) | 1978-11-14 | — | — | US | disclosed |
| US-4031232-A | 1-Alkyl-2-(phenoxymethyl)-5-nitro-imidazoles and process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100094021-A1 | NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES | DCLK2, TH, DCLK3 | CA1 4768/4885CA2 4473/4885ALDH1A1 1245/4885 |
| US-20070123572-A1 | NOVEL METHOD OF PREPARATION OF 5-CHLORO-3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOLE AND (3-IMIDAZOL-1-YL-[1,2,4]THIADIAZOL-5YL)-DIALKYL-AMINES | DCLK2, TH, DCLK3 | CA1 4768/4885CA2 4473/4885ALDH1A1 1245/4885 |
| US-20060247442-A1 | Process for preparing isatins with control of side-product formation | NISCH, HASPIN, INMT | CA1 1872/4885CA2 3776/4885ALDH1A1 1259/4885 |
| US-20080293942-A1 | Methods of Preparing 2-Imidazol-1-Yl-4-Methyl-6-Pyrrolidin-2-Yl-Pyrimidine and 4-(1-Alkylpyrrolidin-2-Yl)-2-(1H-Imidazol-1-Yl)-6-Methylpyrimidine Derivatives | NOS2, NOS1, NOS3 | CA1 4688/4885CA2 2213/4885ALDH1A1 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.