Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 5/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365213 | 0.89 | PKM (0.39) | NCEH1KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL365256 | 0.88 | EGFR (0.40) | NCEH1KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL367734 | 0.78 | ATM (0.40) | NCEH1KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL365490 | 0.77 | NCEH1 (0.39) | NCEH1KMT2AMEN1PKMSRC | |
| SCHEMBL367615 | 0.73 | IDO1 (0.42) | NCEH1KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL366828 | 0.72 | PKM (0.46) | NCEH1KMT2APKMALDH1A1SRC | |
| SCHEMBL367283 | 0.71 | RAB9A (0.44) | NCEH1KMT2APKMALDH1A1SRC | |
| SCHEMBL365189 | 0.70 | ACHE (0.37) | NCEH1ALDH1A1 | |
| SCHEMBL365769 | 0.70 | LTB4R (0.39) | KMT2AMEN1PKMALDH1A1KDM4E | |
| SCHEMBL364802 | 0.70 | KDM4E (0.49) | KMT2AMEN1PKMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |